(+)-<(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl> methyl ether

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (+)-<(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl> methyl ether
• 英文别名: D-menthol methyl ether；(1R,2S,4S)-2-methoxy-4-methyl-1-propan-2-ylcyclohexane
• 化学式: C₁₁H₂₂O
• 分子量: 170.295
• InChiKey: JDGJLPHFRJNJMN-AXFHLTTASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (+)-chloromethyl menthyl ether 在 4,4'-二叔丁基苯并 、 水 、 lithium 作用下， 生成 (+)-<(1S,2R,5S)-2-isopropyl-5-methylcyclohexyl> methyl ether
  参考文献：
  名称：

  Ortiz, Javier; Guijarro, Albert; Yus, Miguel, Anales de Quimica, 1997, vol. 93, # 1, p. 44 - 48

  摘要：

  DOI：

文献信息

• Rapid probing of the reactivity of P450 monooxygenases from the CYP116B subfamily using a substrate-based method
  作者：Ren-Jie Li、Jian-He Xu、Yue-Cai Yin、Nicolas Wirth、Jiang-Meng Ren、Bu-Bing Zeng、Hui-Lei Yu

  DOI：10.1039/c6nj00809g

  日期：——

  Four types ofO-methylated substrates were designed as probes for the detection of fingerprints of Type IV P450s.

  设计了四种O-甲基化底物作为探针，用于检测IV型P450的指纹。
• ALKYL-SUBSTITUTED TETRAHYDROPYRANS AS FLAVORING SUBSTANCES
  申请人：Oertling Heiko

  公开号：US20100226864A1

  公开（公告）日：2010-09-09

  The present invention relates to alkyl-substituted tetrahydropyrans, mixtures containing these alkyl-substituted tetrahydropyrans, their respective use and corresponding flavored products.

  本发明涉及烷基取代的四氢吡喃，含有这些烷基取代的四氢吡喃的混合物，它们的相应用途以及相应的风味产品。
• [EN] PRODRUG OF AMINO ACID DERIVATIVE<br/>[FR] PROMÉDICAMENT DE DÉRIVÉ D'ACIDE AMINÉ
  申请人：TAISHO PHARMA CO LTD

  公开号：WO2017183734A1

  公开（公告）日：2017-10-26

  Provided is an amino acid derivative prodrug represented by general formula (I-A) that is a prodrug form of an amino acid derivative which is a group 2 metabotropic glutamate receptor antagonist, or a pharmaceutically acceptable salt thereof. More specifically, provided is an amino acid derivative prodrug represented by general formula (I-A) that is a preventive or therapeutic drug for mood disorders (including depression and bipolar disorder), anxiety disorder, cognitive disorders, developmental disorders, Alzheimer's disease, Parkinson's disease, movement disorders associated with muscular rigidity, sleep disorders, Huntington's chorea, eating disorders, drug dependence, epilepsy, brain infarction, cerebral ischemia, cerebral insufficiency, cerebral edema, spinal cord disorders, head trauma, inflammation and immune- related diseases, and so on.

  提供的是一种氨基酸衍生物前药，代表为一般式(I-A)，它是一种群2代谷氨酸代谢型谷氨酸受体拮抗剂的前药形式，或其药学上可接受的盐。更具体地，提供的是一种氨基酸衍生物前药，代表为一般式(I-A)，用于预防或治疗情绪障碍（包括抑郁症和躁郁症）、焦虑症、认知障碍、发育障碍、阿尔茨海默病、帕金森病、伴有肌肉僵硬的运动障碍、睡眠障碍、亨廷顿舞蹈症、进食障碍、药物依赖、癫痫、脑梗死、脑缺血、脑供血不足、脑水肿、脊髓疾病、头部创伤、炎症和免疫相关疾病等。
• Unusual o-alkylation with iodomethyltrimethylsilane
  作者：T. K. Chakraborty、G. V. Reddy

  DOI：10.1039/c39890000251

  日期：——

  Iodomethyltrimethylsilane alkylates alkoxide ions giving rise to O-methyl and O-trimethylsilyl ethers which are formed by cleavage of the silicon–carbon bond.

  碘甲基三甲基硅烷烷基化烷氧基离子，生成O-甲基和O-三甲基甲硅烷基醚，它们是通过硅碳键断裂形成的。
• PRODRUG OF AMINO ACID DERIVATIVE
  申请人：Taisho Pharmaceutical Co., Ltd.

  公开号：EP3445743B1

  公开（公告）日：2021-08-04