trimethyl 2,3,4-quinolinetricarboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: trimethyl 2,3,4-quinolinetricarboxylate
• 英文别名: 2-methoxycarbonyl-3,4-dimethoxycarbonylquinoline；trimethyl quinoline-2,3,4-tricarboxylate；quinoline-2,3,4-tricarboxylic acid trimethyl ester；Chinolin-2,3,4-tricarbonsaeure-trimethylester；Trimethyl quinoline-2,3,4-tricarboxylate
• 化学式: C₁₅H₁₃NO₆
• 分子量: 303.271
• InChiKey: VJMOXMZXJOIGDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  91.8
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-苯基甘氨酸甲酯 、 丁炔二酸二甲酯 在 过氧化二异丙苯 、 rose bengal 作用下， 以 二甲基亚砜 为溶剂， 以55 %的产率得到trimethyl 2,3,4-quinolinetricarboxylate
  参考文献：
  名称：

  CN115557888

  摘要：

  公开号：

文献信息

• Formation of trialkyl quinoline-2,3,4-tricarboxylates by reaction of isatin, dialkyl acetylenedicarboxylates, and sodium O-alkyl carbonodithioates
  作者：Issa Yavari、Samereh Seyfi、Zinatossadat Hossaini

  DOI：10.1016/j.tetlet.2010.02.107

  日期：2010.4

  An efficient one-pot synthesis of quinoline-2,3,4-tricarboxylates is described by reaction of isatin (indoline-2,3-dione) and electron-deficient acetylenic esters in the presence of sodium O-alkyl carbonodithioates, themselves prepared by addition of sodium hydride to a solution of an alcohol in CS2. (C) 2010 Published by Elsevier Ltd.
• A Novel One-Pot Synthesis of Substituted Quinolines
  作者：Maryam Sabbaghan、Issa Yavari、Zinatossadat Hossaini、Sanaz Souri

  DOI：10.1002/hlca.200900304

  日期：2010.5

  AbstractA synthesis of quinoline derivatives is described via reaction between ethyl bromopyruvate (=ethyl 3‐bromo‐2‐oxopropanoate), acetylenedicarboxylate, and isatin (=1H‐indole‐2,3‐dione) in the presence of NaH as a base. Also, these reactions were performed without ethyl bromopyruvate. The reaction in the presence of ethyl bromopyruvate provides regioselectively a quinoline with the ethyl ester group in 4‐position. In the absence of ethyl bromopyruvate, the reaction leads to functionalized quinolines with the same ester groups in 2‐, 3‐, and 4‐positions.
• Nano KF/Clinoptilolite: An Effective Heterogeneous Base Nanocatalyst for Synthesis of Substituted Quinolines in Water
  作者：Hadi Sajjadi-Ghotbabadi、Shahrzad Javanshir、Faramarz Rostami-Charati

  DOI：10.1007/s10562-015-1652-y

  日期：2016.2

  A proficient, green and environmentally benign one-pot three-component synthesis of functionalized quinolines was developed by condensation reactions of isatin, activated acetylenic compounds, and alcohols in the presence of KF/CP (NPs) as a heterogeneous base nanocatalyst, at room temperature in water.[GRAPHICS]
• CN115557888
  申请人：——

  公开号：——

  公开（公告）日：——