2-(tert-butoxymethyl)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(tert-butoxymethyl)quinoline
• 英文别名: 2-[(2-Methylpropan-2-yl)oxymethyl]quinoline
• 化学式: C₁₄H₁₇NO
• 分子量: 215.295
• InChiKey: IKQOPTLNYWMXML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  22.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  喹啉 、 甲基叔丁基醚 在 二叔丁基过氧化物 、 yttrium(III) trifluoromethanesulfonate 作用下， 反应 24.0h， 以42%的产率得到2-(tert-butoxymethyl)quinoline
  参考文献：
  名称：

  Rare-Earth Y(OTf)₃ Catalyzed Coupling Reaction of Ethers with Azaarenes

  摘要：

  Rare-earth catalysis has become a hot topic in the field of catalytic organic reaction. Chain ethers mostly have lower reactivity and lower boiling points which limited their reaction scope. Herein, we found a rare-earth Y(OTf)(3) can catalyze the coupling reaction of ethers especially chain ethers and thioethers with azaarenes. This protocol features simple operations, a broad substrate scope (31 examples), moderate to good yields (up to 85%), and atom economy.

  DOI：

  10.1021/acs.orglett.9b02763

文献信息

• DIPHENYL SUBSTITUTED CYCLOALKANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE
  申请人：Chu Lin

  公开号：US20100152185A1

  公开（公告）日：2010-06-17

  The instant invention provides compounds of formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.

  本发明提供了式I的化合物，其是5-脂氧合酶激活蛋白的抑制剂。式I的化合物可用作抗动脉粥样硬化、抗哮喘、抗过敏、抗炎和细胞保护剂。
• US7629467B2
  申请人：——

  公开号：US7629467B2

  公开（公告）日：2009-12-08
• Rare-Earth Y(OTf)₃ Catalyzed Coupling Reaction of Ethers with Azaarenes
  作者：Yue-Hua Wu、Nai-Xing Wang、Tong Zhang、Lei-Yang Zhang、Xue-Wang Gao、Bao-Cai Xu、Yalan Xing、Jian-Yi Chi

  DOI：10.1021/acs.orglett.9b02763

  日期：2019.9.20

  Rare-earth catalysis has become a hot topic in the field of catalytic organic reaction. Chain ethers mostly have lower reactivity and lower boiling points which limited their reaction scope. Herein, we found a rare-earth Y(OTf)(3) can catalyze the coupling reaction of ethers especially chain ethers and thioethers with azaarenes. This protocol features simple operations, a broad substrate scope (31 examples), moderate to good yields (up to 85%), and atom economy.