鸡蛋花素 | 77-16-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 鸡蛋花素
• 英文名称: plumericin
• 英文别名: methyl (1S,4S,8R,10S,11E,14S)-11-ethylidene-12-oxo-7,9,13-trioxatetracyclo[6.5.1.01,10.04,14]tetradeca-2,5-diene-5-carboxylate
• CAS: 77-16-7
• 化学式: C₁₅H₁₄O₆
• 分子量: 290.273
• InChiKey: VFXXNAVZODKBIW-JKXVGBJFSA-N

物化性质

• 比旋光度：
  D25 +197.5 ±2° (c = 0.982 in chloroform)
• 沸点：
  352.36°C (rough estimate)
• 密度：
  1.2451 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Iridoid-saccharide compound and method of using same
  申请人：HEALTH RESEARCH, INC.

  公开号：EP1527783A1

  公开（公告）日：2005-05-04

  A method for treatment of hyperproliferative tissue which by exposing the hyperproliferative tissue to a sufficient quantity of a purified iridoid compound to inhibit its growth, where the iridoid compound includes a polysubstituted cyclopenta(c)dihydropyran where the cyclopenta ring is substituted at its 2' position with a ketofuryl group, where the numbering of the fused cyclopenta(c)dihydropyran ring structure includes heterocyclic oxygen, is counterclockwise and begins at the first carbon atom counterclockwise from the cyclopcnta ring so that oxygen is in the 2 position in the pyran ring. The invention also includes the mouse iridoid compounds.

  一种治疗过度增生组织的方法，该方法是将过度增生组织暴露于足量的纯化铱类化合物中以抑制其生长，其中铱类化合物包括多取代环戊(c)二氢吡喃，环戊环在其 2'位置被酮呋喃基取代、其中，融合的环戊（c）二氢吡喃环结构的编号包括杂环氧，为逆时针编号，从环戊环逆时针方向的第一个碳原子开始，这样氧就位于吡喃环的 2 位。本发明还包括小鼠铱类化合物。
• COMPOSITION CONTAINING IRIDOIDS AND USES THEREOF
  申请人：Xuanwu Hospital of Capital Medical University

  公开号：EP2581087A1

  公开（公告）日：2013-04-17

  Composition containing iridoids such as morroniside and loganin, the use thereof in preparing medicaments for preventing and treating neurologic demyelinating diseases, and the method thereof in treating diseases related to neurologic demyelinating lesions are disclosed by the present application.

  本申请公开了含有莫罗尼苷（morroniside）和洛伽宁（loganin）等虹苷类化合物的组合物、其在制备用于预防和治疗神经系统脱髓鞘疾病的药物中的用途，以及其在治疗与神经系统脱髓鞘病变有关的疾病中的方法。
• AN ESTERASE THAT IS CAPABLE OF CONVERTING IRIDOIDS AND SECO-IRIDOIDS
  申请人：N-Zyme BioTec GmbH

  公开号：EP3409766A1

  公开（公告）日：2018-12-05

  The present invention relates to a polypeptide having esterase activity selected from the group consisting of (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 7; (b) a polypeptide that is at least 60 % identical to the amino acid sequence of SEQ ID NO: 7 and which is characterized by having an esterase activity; (c) a polypeptide encoded by a nucleic acid molecule which is at least 60 % identical to the nucleic acid sequence of SEQ ID NO: 5 or 6 wherein said polypeptide is characterized by having an esterase activity; (d) a polypeptide encoded by the nucleic acid molecule of SEQ ID NO: 5 or 6; and (e) a polypeptide encoded by the complementary sequence of a nucleic acid molecule that is able to hybridize with the nucleic acid molecule of SEQ ID NO: 5 or 6. Further, the present invention relates to a polypeptide having esterase activity selected from the group consisting of SEQ ID NO: 24 and 37 (as encoded by nuleic acid molecule of SEQ ID NO: 22 or 23 and SEQ ID NO: 35 and 36). The present invention also relates to a method for the production of oleacein, oleocanthal, or decarboxymethyl elenolic acid dialdehyde (DEDA) comprising the use of the esterase of the present invention. to an organism, preferably a plant cell, genetically engineered with a nucleic acid molecule encoding a polypeptide characterized by having an esterase activity or the vector of the present invention. The present invention also relates to a method for the production of oleacein, oleocanthal, and/or decarboxymethyl elenolic acid dialdehyde (DEDA) comprising the use of the esterase of the present invention.

  本发明涉及一种具有酯酶活性的多肽，该多肽选自由以下组成的组 (a) 包含 SEQ ID NO: 7 的氨基酸序列的多肽；(b) 与 SEQ ID NO: 7 的氨基酸序列至少 60% 相同的多肽，其特征在于具有酯酶活性；(c) 由核酸分子编码的多肽，该核酸分子与 SEQ ID NO: 5 或 6 的核酸序列至少 60% 相同，其中所述多肽的特征在于具有酯酶活性；(d) 由 SEQ ID NO: 5 或 6 的核酸分子编码的多肽；以及(e) 由 SEQ ID NO: 6 的核酸分子编码的多肽：5或6的核酸分子编码的多肽，其中所述多肽的特征在于具有酯酶活性；(d)由SEQ ID NO：5或6的核酸分子编码的多肽；以及(e)由能够与SEQ ID NO：5或6的核酸分子杂交的核酸分子的互补序列编码的多肽。此外，本发明涉及一种具有酯酶活性的多肽，该多肽选自 SEQ ID NO: 24 和 37（由 SEQ ID NO: 22 或 23 和 SEQ ID NO: 35 和 36 的核酸分子编码）组成的组。本发明还涉及一种生产油菜素、油菜醛或脱羧甲基烯醇酸二醛（DEDA）的方法，包括使用本发明的酯酶。本发明涉及一种生物体，最好是植物细胞，其基因工程中含有编码具有酯酶活性的多肽的核酸分子或本发明的载体。本发明还涉及一种生产油菜素、油菜醛和/或脱羧甲基烯醇酸二醛（DEDA）的方法，包括使用本发明的酯酶。
• CXCR antagonistic peptides and uses thereof
  申请人：STC.UNM

  公开号：US10548942B2

  公开（公告）日：2020-02-04

  The present invention provides a novel class of medicament based on CXCR antagonistic peptides. Among other things, the present invention provides peptides, compositions and methods for treating diseases, disorders and conditions in which a CXCR mediated pathway is implicated. Compositions and methods for effective treatment of inflammation, stroke, traumatic brain injury, pancreatic cancer, and others are provided.

  本发明提供了一类基于 CXCR 拮抗肽的新型药物。除其他外，本发明还提供了用于治疗涉及 CXCR 介导途径的疾病、失调和病症的多肽、组合物和方法。本发明提供了有效治疗炎症、中风、创伤性脑损伤、胰腺癌等疾病的组合物和方法。
• Anti-LSP1 antibody
  申请人：INSTITUT CURIE

  公开号：US10968281B2

  公开（公告）日：2021-04-06

  The present invention provides a new anti-LSP1 (Leukocyte specific protein 1) antibody. This new antibody allows the specific staining of inflammatory dendritic cells and can be used in diagnosis methods or as a medicament when conjugated to a drug.

  本发明提供了一种新型抗 LSP1（白细胞特异性蛋白 1）抗体。这种新型抗体可对炎性树突状细胞进行特异性染色，可用于诊断方法或与药物结合后用作药物。