二氢维生素K1二磷酸酯 | 6078-42-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 二氢维生素K1二磷酸酯
• 英文名称: Phytonadiol diphosphate
• 英文别名: [2-methyl-4-phosphonooxy-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalen-1-yl] dihydrogen phosphate
• CAS: 6078-42-8
• 化学式: C₃₁H₅₀O₈P₂
• 分子量: 612.7
• InChiKey: GWPPODHQIFSQLZ-NKFFZRIASA-N

物化性质

• 熔点：
  198-200 °C
• 沸点：
  754.8±70.0 °C(Predicted)
• 密度：
  1.183±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  9.3
• 重原子数：
  41
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  二氢维他命 K1 、 二氢维生素K1二磷酸酯 生成 3,14-dihydroxy-23,26-dimethyl-24,25-bis[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]-2,4,13,15-tetraoxa-3λ5,14λ5-diphosphapentacyclo[14.6.2.25,12.06,11.017,22]hexacosa-1(23),5(26),6,8,10,12(25),16(24),17,19,21-decaene 3,14-dioxide
  参考文献：
  名称：

  ZHUKOVA, LESLEU;EH.;ZAXAROVA, E. CARNER SARYCHEVA I. K.;EVSTIGNEEVA, R. N+, BIOORGAN. XIMIYA, 14,(1988) N 5, 681-688

  摘要：

  DOI：
• 作为产物：
  描述：

  二氢维他命 K1 生成 二氢维生素K1二磷酸酯
  参考文献：
  名称：

  ZHUKOVA, LESLEU;EH.;ZAXAROVA, E. CARNER SARYCHEVA I. K.;EVSTIGNEEVA, R. N+, BIOORGAN. XIMIYA, 14,(1988) N 5, 681-688

  摘要：

  DOI：

文献信息

• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• ZHUKOVA, LESLEU;EH.;ZAXAROVA, E. CARNER SARYCHEVA I. K.;EVSTIGNEEVA, R. N+, BIOORGAN. XIMIYA, 14,(1988) N 5, 681-688
  作者：ZHUKOVA, LESLEU、EH.、ZAXAROVA, E. CARNER SARYCHEVA I. K.、EVSTIGNEEVA, R. N+

  DOI：——

  日期：——
• Vitamin K1 and uses thereof
  申请人：Pharmadab d.o.o.

  公开号：EP2712613B1

  公开（公告）日：2017-02-08
• Methods and devices for the treatment of ocular conditions
  申请人：deJuan Eugene

  公开号：US20060110428A1

  公开（公告）日：2006-05-25

  Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.
• METHODS AND DEVICES FOR THE TREATMENT OF OCULAR CONDITIONS
  申请人：deJuan Eugene

  公开号：US20110159073A1

  公开（公告）日：2011-06-30

  Featured is a method for instilling one or more bioactive agents into ocular tissue within an eye of a patient for the treatment of an ocular condition, the method comprising concurrently using at least two of the following bioactive agent delivery methods (A)-(C): (A) implanting a sustained release delivery device comprising one or more bioactive agents in a posterior region of the eye so that it delivers the one or more bioactive agents into the vitreous humor of the eye; (B) instilling (e.g., injecting or implanting) one or more bioactive agents subretinally; and (C) instilling (e.g., injecting or delivering by ocular iontophoresis) one or more bioactive agents into the vitreous humor of the eye.