3-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)benzoic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)benzoic acid
• 英文别名: 5,6,7-Trimethoxyflavone-3'-carboxylic acid；3-(5,6,7-trimethoxy-4-oxochromen-2-yl)benzoic acid
• 化学式: C₁₉H₁₆O₇
• 分子量: 356.332
• InChiKey: HJRUSINFGNAGBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)benzoic acid 在 碘 、 三氯化硼 、 三乙胺 、 三甲氧基磷 作用下， 以 二氯甲烷 为溶剂， 反应 6.67h， 生成 N-(benzo[d][1,3]dioxol-5-yl)-3-(5-hydroxy-6,7-dimethoxy-4-oxo-4H-chromen-2-yl)benzamide
  参考文献：
  名称：

  天然产物杂化物：3,5,4'-三甲氧基苯乙烯-5,6,7-三甲氧基黄酮嵌合类似物作为针对多种人类癌细胞的潜在细胞毒性剂

  摘要：

  癌症仍然是全球主要的健康问题。当前所有可用的抗癌剂均具有诸如耐药性或副作用之类的缺点。因此，需要引入新型抗癌剂。出于对基于天然产物的药物发现的高成功率的兴趣，我们设计并合成了抗增殖化学实体，将其作为两种天然产物的混合物；3,5,4'-三甲氧基sti和5,6,7-三甲氧基黄酮。为了探测合成化合物的光谱，针对代表主要癌症疾病的九个小组进行了体外评估。结果显示杂化类似物4f，4h，4k和4q作为有前途的广谱抗癌先导化合物，可引起代表多种癌症疾病的几种细胞系的高生长抑制作用。对有前景的先导化合物针对正常人细胞系的评估表明对癌细胞具有选择性的细胞毒性作用。对化合物4f在人宫颈癌HeLa细胞中的细胞毒活性的机理研究表明，它通过诱导凋亡来触发细胞死亡。总体而言，这项研究提出了天然产物杂合类似物4f，4h，4k和4q作为潜在的先导化合物，用于进一步开发新型抗癌疗法。

  DOI：

  10.1016/j.ejmech.2018.10.062
• 作为产物：
  描述：

  3,4,5-三甲氧基苯酚 在 三氟化硼乙醚 、 碘 、 sodium methylate 、 C.I.酸性橙108 、 potassium hydroxide 作用下， 以 甲醇 、 二甲基亚砜 为溶剂， 生成 3-(5,6,7-trimethoxy-4-oxo-4H-chromen-2-yl)benzoic acid
  参考文献：
  名称：

  天然产物杂化物：3,5,4'-三甲氧基苯乙烯-5,6,7-三甲氧基黄酮嵌合类似物作为针对多种人类癌细胞的潜在细胞毒性剂

  摘要：

  癌症仍然是全球主要的健康问题。当前所有可用的抗癌剂均具有诸如耐药性或副作用之类的缺点。因此，需要引入新型抗癌剂。出于对基于天然产物的药物发现的高成功率的兴趣，我们设计并合成了抗增殖化学实体，将其作为两种天然产物的混合物；3,5,4'-三甲氧基sti和5,6,7-三甲氧基黄酮。为了探测合成化合物的光谱，针对代表主要癌症疾病的九个小组进行了体外评估。结果显示杂化类似物4f，4h，4k和4q作为有前途的广谱抗癌先导化合物，可引起代表多种癌症疾病的几种细胞系的高生长抑制作用。对有前景的先导化合物针对正常人细胞系的评估表明对癌细胞具有选择性的细胞毒性作用。对化合物4f在人宫颈癌HeLa细胞中的细胞毒活性的机理研究表明，它通过诱导凋亡来触发细胞死亡。总体而言，这项研究提出了天然产物杂合类似物4f，4h，4k和4q作为潜在的先导化合物，用于进一步开发新型抗癌疗法。

  DOI：

  10.1016/j.ejmech.2018.10.062

文献信息

• 플라본 유도체 및 그를 포함하는 항암제 조성물
  申请人：University-Industry Cooperation Group of Kyung Hee University 경희대학교 산학협력단(220040073623) BRN ▼135-82-10789

  公开号：KR101593472B1

  公开（公告）日：2016-02-12

  본 발명은 우수한 항암 활성을 가지는 플라본 유도체, 그의 제조방법 및 그를 유효성분으로 포함하는 항암제 조성물을 제공한다.

  本发明提供了具有优异抗癌活性的皮质类固醇衍生物，其制备方法以及包含其作为有效成分的抗癌药物组合物。
• Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators
  作者：Ahmed H.E. Hassan、Sung Yeun Yoo、Kun Won Lee、Yoon Mi Yoon、Hye Won Ryu、Youngdo Jeong、Ji-Sun Shin、Shin-Young Kang、Seo-Yeon Kim、Hwi-Ho Lee、Boyoung Y. Park、Kyung-Tae Lee、Yong Sup Lee

  DOI：10.1016/j.ejmech.2019.07.030

  日期：2019.10

  Herein, we address repurposing hybrids of mosloflavone or 5,6,7-trimethoxyflavone with amide analogs of resveratrol from anticancer leads to novel potent anti-inflammatory chemical entities. To unveil the potent anti-inflammatory molecules, biological evaluations were initiated in LPS-induced RAW 264.7 macrophages at 1 mu M concentration. Promising compounds were further evaluated at various concentrations. Multiple proinflammatory mediators were assessed including NO, PGE(2), IL-6, TNF-alpha and IL-1 beta. Compound 5z inhibited the induced production of NO, PGE(2), IL-6, TNF-alpha and IL-1 beta at the low 1 mu M concentration by 44.76, 35.71, 53.48, 29.39 and 41.02%, respectively. Compound 5z elicited IC50 values as low as 2.11 and 0.98 mu M against NO and PGE(2) production respectively. Compounds 5q and 5g showed potent submicromolar IC50 values of 0.31 and 0.59 mu M respectively against PGE(2) production. Reverse docking of compound 5z suggested p38-alpha MAPK, which is a key signaling molecule within the pathways controlling the transcription of proinflammatory mediators, as the molecular target. Biochemical testing confirmed these compounds as p38-alpha MAPK inhibitors explaining its potent inhibition of proinflammatory mediators' production. Collectively, the results presented 5z as a promising compound for further development of anti-inflammatory agents for treatment of macrophages-and/or immune mediated inflammatory diseases. (C) 2019 Elsevier Masson SAS. All rights reserved.
• Flavone-based arylamides as potential anticancers: Design, synthesis and in vitro cell-based/cell-free evaluations
  作者：Ahmed H.E. Hassan、Kyung-Tae Lee、Yong Sup Lee

  DOI：10.1016/j.ejmech.2019.111965

  日期：2020.2

  Several arylamide-based antiproliferative agents are known and some of them are currently FDA-approved anticancer drugs. Provoked by the need to fill the existing room with new drugs, 31 compounds constituting a series of flavone-based arylamide derivatives were synthesized and biologically evaluated. Towards extensive evaluation, sixty diverse cancer cell lines representing nine cancer diseases of various origins have been used for evaluation of their efficacy, spectrum and potency. Two compounds 2aw and 2ax emerged as effective, broad-spectrum and potent anticancer agents that outperformed masitinibt and imatininb, which are FDA-approved anticancer drugs. Kinases profiling as possible targets for the potent compound 2aw showed that it might be a hit compound offering a starting point to develop inhibitors of STE20/GCK-IV kinase family members including HGK, TNIK and MINK1 kinases. Mechanistic study showed that compounds 2aw triggers cell cycle arrest in HT29 colon cancer cells. In conclusion, this work presents compound 2aw as a new broad-spectrum anticancer agent for further development of promising treatment of diverse cancers. (C) 2019 Elsevier Masson SAS. All rights reserved.