1,2-bis[(1R,2R,4R)-7,7-dimethyl-1-mesitylsulfanylmethylbicyclo[2.2.1]heptane-2-thio]acetylene

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1,2-bis[(1R,2R,4R)-7,7-dimethyl-1-mesitylsulfanylmethylbicyclo[2.2.1]heptane-2-thio]acetylene
• 英文别名: (1R,2R,4R)-2-[2-[[(1R,2R,4R)-7,7-dimethyl-1-[(2,4,6-trimethylphenyl)methylsulfanylmethyl]-2-bicyclo[2.2.1]heptanyl]sulfanyl]ethynylsulfanyl]-7,7-dimethyl-1-[(2,4,6-trimethylphenyl)methylsulfanylmethyl]bicyclo[2.2.1]heptane
• 化学式: C₄₂H₅₈S₄
• 分子量: 691.187
• InChiKey: MDQQTTKGZATWTF-QTHOLGIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.5
• 重原子数：
  46
• 可旋转键数：
  12
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  101
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二氯乙炔 、 (1S,2R,4R)-7,7-dimethyl-1-[(2,4,6-trimethylbenzylsulfanyl)methyl]bicyclo[2.2.1]heptane-2-thiol 在 六甲基二硅氮烷 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 24.0h， 生成 1,2-bis[(1R,2R,4R)-7,7-dimethyl-1-mesitylsulfanylmethylbicyclo[2.2.1]heptane-2-thio]acetylene
  参考文献：
  名称：

  Efficient synthesis of chiral acetylene dithioethers in enantiomerically pure form

  摘要：

  Chiral acetylene dithioethers have been synthesized by the first time in enantiomerically pure form through a high yield (93-100%), one-pot procedure involving the successive treatment of trichloroethylene with three equivalents of lithium bis(trimethylsilyl)amide and two equivalents of a chiral thiol in diethyl ether solution. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0957-4166(97)00126-2

文献信息

• Efficient synthesis of chiral acetylene dithioethers in enantiomerically pure form
  作者：Jaume Balsells、Albert Moyano、Miquel A. Pericàs、Antoni Riera

  DOI：10.1016/s0957-4166(97)00126-2

  日期：1997.5

  Chiral acetylene dithioethers have been synthesized by the first time in enantiomerically pure form through a high yield (93-100%), one-pot procedure involving the successive treatment of trichloroethylene with three equivalents of lithium bis(trimethylsilyl)amide and two equivalents of a chiral thiol in diethyl ether solution. (C) 1997 Elsevier Science Ltd.