2-(4-isopropylbenzyl) pyridine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-(4-isopropylbenzyl) pyridine
• 英文别名: 2-(4-Isopropyl-benzyl)-pyridin；2-[(4-Propan-2-ylphenyl)methyl]pyridine；2-[(4-propan-2-ylphenyl)methyl]pyridine
• 化学式: C₁₅H₁₇N
• 分子量: 211.307
• InChiKey: RIEYMGGMDCADBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(4-isopropylbenzyl) pyridine 在 氨 、 potassium amide 作用下， 生成 [3-(4-isopropyl-phenyl)-3-[2]pyridyl-propyl]-dimethyl-amine
  参考文献：
  名称：

  Histamine Antagonists. γ,γ-Disubstituted N,N-Dialkylpropylamines¹

  摘要：

  DOI：

  10.1021/ja01156a078
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯化亚砜 、 苯 作用下， 生成 2-(4-isopropylbenzyl) pyridine
  参考文献：
  名称：

  Chemistry of the Benzylpyridines. II. Nuclear Substituted 2-Benzylpyridines¹

  摘要：

  DOI：

  10.1021/ja01152a088

文献信息

• Aryl Substituted Indoles and Their Use as Blockers of Sodium Channels
  申请人：Kyle Donald J.

  公开号：US20130296281A1

  公开（公告）日：2013-11-07

  The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R 1 , and Z 1 -Z 5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及具有式（I）的芳基和杂芳基取代化合物，以及其药学上可接受的盐、前药或溶剂化物，其中G、R1和Z1-Z5如规范中所述。本发明还涉及利用式（I）的化合物治疗对钠通道阻滞有响应的疾病。本发明的化合物特别适用于治疗疼痛。
• Catalytic Selective Metal-Free Cross-Coupling of Heteroaromatic <i>N</i>-Oxides with Organosilanes
  作者：Mahesh Puthanveedu、Vasiliki Polychronidou、Andrey P. Antonchick

  DOI：10.1021/acs.orglett.9b01141

  日期：2019.5.3

  of heteroaromatic N-oxides has been developed. The method enables the synthesis of various benzylated and alkynylated N-heterocycles in a transition-metal-free manner employing organosilanes as coupling partners. The unanticipated reactivity has been exploited for the synthesis of a number of symmetrical disubstituted acetylenes from ethynyltrimethylsilane via carbon–silicon bond metathesis.

  已经开发出了无金属，区域选择性的杂芳族N-氧化物的C H功能化。该方法使得能够以无过渡金属的方式使用有机硅烷作为偶联伙伴来合成各种苄基化和炔基化的N-杂环。不可预料的反应活性已被用于通过乙炔基三甲基硅烷通过碳-硅键的复分解反应合成许多对称的二取代的乙炔。
• HETEROARYL COMPOUNDS AS SODIUM CHANNEL BLOCKERS
  申请人：Purdue Pharma L.P.

  公开号：US20140288092A1

  公开（公告）日：2014-09-25

  The invention relates to aryl substituted compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein Het, G, A, R, and n are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及公式（I）的芳基取代化合物及其药学上可接受的盐、前药或溶剂，其中Het、G、A、R和n如规范中所述。本发明还涉及使用公式I的化合物治疗对钠通道阻滞有响应的疾病。本发明的化合物特别适用于治疗疼痛。
• ARYL SUBSTITUTED INDOLES AND THE USE THEREOF
  申请人：Purdue Pharma L.P.

  公开号：US20160326111A1

  公开（公告）日：2016-11-10

  The invention relates to aryl and heteroaryl substituted compounds of Formula (I), and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein G, R 1 , and Z 1 -Z 5 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to the blockade of sodium channels. Compounds of the present invention are especially useful for treating pain.
• BETA-ADRENERGIC RECEPTOR ALLOSTERIC MODULATORS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20210353626A1

  公开（公告）日：2021-11-18

  Provided herein are modulators of beta-adrenergic receptors.