4,4'-(perfluoroprop-1-ene-1,1-diyl)bis(methylbenzene)

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 4,4'-(perfluoroprop-1-ene-1,1-diyl)bis(methylbenzene)
• 化学式: C₁₇H₁₄F₄
• 分子量: 294.292
• InChiKey: IDSQOQGKDMXXST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.59
• 重原子数：
  21.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  (三氟甲基)三甲基硅烷 、 4,4'-(2,2-difluoroethene-1,1-diyl)bis(methylbenzene) 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以85%的产率得到4,4'-(perfluoroprop-1-ene-1,1-diyl)bis(methylbenzene)
  参考文献：
  名称：

  Mild and metal-free trifluoromethylation and pentafluoroethylation of gem-difluoroalkenes with TMSCF3 and TMSCF2CF3

  摘要：

  A direct and efficient approach for the trifluoromethylation and pentafluoroethylation of 1,1-diary1-2,2-difluoroethenes with TMSCF3 and TMSCF2CF3 in the presence of TBAF was developed. The reactions proceeded smoothly under mild reaction conditions to give the corresponding monotrifluoromethylated, bistrifluoromethylated, monopentafluoroethylated and bispentafluoroethylated products in fair to good yields, respectively, without the addition of metal catalyst. (c) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.08.016

文献信息

• Mild and metal-free trifluoromethylation and pentafluoroethylation of gem-difluoroalkenes with TMSCF3 and TMSCF2CF3
  作者：Guanyi Jin、Xuxue Zhang、Dan Fu、Wenpeng Dai、Song Cao

  DOI：10.1016/j.tet.2015.08.016

  日期：2015.10

  A direct and efficient approach for the trifluoromethylation and pentafluoroethylation of 1,1-diary1-2,2-difluoroethenes with TMSCF3 and TMSCF2CF3 in the presence of TBAF was developed. The reactions proceeded smoothly under mild reaction conditions to give the corresponding monotrifluoromethylated, bistrifluoromethylated, monopentafluoroethylated and bispentafluoroethylated products in fair to good yields, respectively, without the addition of metal catalyst. (c) 2015 Elsevier Ltd. All rights reserved.