benzotrithiol

• 分子结构分类: 有机化合物 - 苯类化合物
• 英文名称: benzotrithiol
• 英文别名: benzotrithiole；1,2,3-benzotrithiole
• 化学式: C₆H₄S₃
• 分子量: 172.296
• InChiKey: IXJYHBIHBHISCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2-benzenebis(sulfenyl chloride) 在 二硫化碳 、 ZnS₆(TMEDA) 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 benzotrithiol
  参考文献：
  名称：

  Polysulfane Antitumor Agents from o-Benzyne. An Odd−Even Alternation Found in the Stability of Products o-C₆H₄S_x (x = 1−8)

  摘要：

  Benzyne is shown to add elemental sulfur and give rise to a series of polysulfane compounds. A computational and experimental study is presented. Odd-membered o-C6H4Sx rings (x = 1-8), except x = 1, which suffers from ring strain, have enhanced stability compared to even-membered rings. The acquisition of "odd-even" data may shed new light, revealing patterns on polysulfane stability and structure.

  DOI：

  10.1021/jo049418w

文献信息

• [EN] PYRIMIDINE-FUSED CYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF<br/>[FR] COMPOSÉ CYCLIQUE FUSIONNÉ À UNE PYRIMIDINE, SON PROCÉDÉ DE PRÉPARATION ET SON APPLICATION<br/>[ZH] 嘧啶并环化合物及其制备方法和应用
  申请人：SHANGHAI BLUERAY BIOPHARMA CO LTD

  公开号：WO2019158019A1

  公开（公告）日：2019-08-22

  本发明公开了嘧啶并环化合物、其药学上可接受的盐、水合物、前药、立体异构体、溶剂化物或其同位素标记化合物，本发明也提供了该类化合物的制备方法、含有该类化合物的组合物以及该类化合物用于在制备预防和/或治疗与SHP2活性异常相关疾病或病症的药物方面的用途。
• New Polysulfur‐Nitrogen Heterocycles by Thermolysis of 1,3λ ⁴ δ ² ,2,4‐Benzodithiadiazines in the Hydrocarbon and Fluorocarbon Series
  作者：Vladimir V. Zhivonitko、Alexander Yu. Makarov、Irina Yu. Bagryanskaya、Yuri V. Gatilov、Makhmut M. Shakirov、Andrey V. Zibarev

  DOI：10.1002/ejic.200500383

  日期：2005.10

  AbstractIn contrast to thermolysis of 1,3λ4δ2,2,4‐benzodithiadiazine (1) and its 5,6,7,8‐tetrafluoro derivative 2 in dilute (10–3 M) hydrocarbon solutions, which leads to persistent 1,2,3‐benzodithiazolyls in nearly quantitative yields, the thermolysis of 1 and 2 (the 6‐6 bicyclic system) in concentrated (0.5 M) solutions at 150–170 °C results in complex mixtures of various polysulfur‐nitrogen heterocycles, in particular differently fused 5‐5‐6, 5‐6‐7 and 5‐6‐6‐6 polycyclic systems that were previously unknown. The products were isolated by column chromatography, and the structures of the 5‐5‐6 (11, 12), 5‐6‐7 (5, 13), and 5‐6‐6‐6 (6, 14, 15) polycyclic systems, as well as the 6‐7 (4) and 5‐6 (16) bicyclic derivatives, confirmed by X‐ray diffraction. The crystal packing of 6 and 11–16 is discussed with special emphasis on π‐stacking interactions. The fluorescent properties of the 5‐6‐6‐6 systems synthesized are reported. An alternative approach to the linear 5‐6‐6‐6 system 15 based on self‐condensation of an R–N=PPh3 precursor (R = 4,5,6,7‐tetrafluoro‐1,2,3‐benzodithiazol‐2‐yl) is described, and the free‐radical character of this new reaction is proved. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
• Implications for the Existence of a Heptasulfur Linkage in Natural <i>o</i>-Benzopolysulfanes
  作者：David Aebisher、Edyta M. Brzostowska、Nahed Sawwan、Rafael Ovalle、Alexander Greer

  DOI：10.1021/np070108t

  日期：2007.9.1

  Natural o-benzopolysulfanes are often thought to exist as either the trisulfane or pentasulfane; the nomenclature has evolved around such notions. No study makes reference to the possible existence of natural o-benzoheptasulfanes. The work performed here indicates that a facile equilibration takes place between the tri-, penta-, and heptasulfanes (o-C6H4S3, o-C6H4S5, and o-C6H4S7) in solution. In these simpler (unnatural) compounds, the number of sulfur atoms can be established unequivocally from their independent syntheses. The o-benzopolysulfanes, even after purification, yield mixtures of compounds in solution. A similar equilibration may be anticipated for the corresponding natural products.
• EP3753941A1
  申请人：——

  公开号：EP3753941A1

  公开（公告）日：2020-12-23
• CURABLE RESIN, SEALING MEMBER, AND ELECTRONIC DEVICE PRODUCT USING SEALING MEMBER
  申请人：DENSO CORPORATION

  公开号：US20150166728A1

  公开（公告）日：2015-06-18

  A curable resin composition includes a main agent, an amine-based curing agent, and a phenol-based curing agent. The main agent includes at least one of a maleimide compound and an epoxy compound. The amine-based curing agent is made of aromatic polyamine. The phenol-based curing agent is made of phenols that has a phenolic OH equivalent of equal to or less than 90 and has a softening point or a melting point of equal to or lower than 100° C.