（1R，1′R，2S，2′S）-2，2′-二叔丁基-2，3，2′，3′-四氢-1H，1′H-（1，1′）二异磷哚 | 528814-26-8

• 分子结构分类: 有机化合物 - 苯类化合物
• 中文名称: （1R，1′R，2S，2′S）-2，2′-二叔丁基-2，3，2′，3′-四氢-1H，1′H-（1，1′）二异磷哚
• 中文别名: (1R,1′R,2S,2′S)-2,2′-二叔丁基-2,3,2′,3′-四氢-1H,1′H-(1,1′)二异磷哚；(1R,1''R,2S,2''S)-2,2''-二叔丁基-2,3,2'',3''-四氢-1H,1''H-(1,1'')二异磷哚
• 英文名称: (1R,1'R,2S,2'S)-DuanPhos
• 英文别名: (1R)-2-tert-butyl-1-[(1R)-2-tert-butyl-1,3-dihydroisophosphindol-1-yl]-1,3-dihydroisophosphindole
• CAS: 528814-26-8
• 化学式: C₂₄H₃₂P₂
• 分子量: 382.5
• InChiKey: HCBRTCFUVLYSKU-URFUVCHWSA-N

物化性质

• 熔点：
  214-246 °C
• 比旋光度：
  +19.5
• 沸点：
  474.5±45.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• WGK Germany：
  3

文献信息

• PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIATE COMPOUNDS
  申请人：Zhou Jiacheng

  公开号：US20100190981A1

  公开（公告）日：2010-07-29

  The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

  本发明涉及制备手性取代吡唑基吡咯并[2,3-d]嘧啶的公式III的过程，以及相关的合成中间体化合物。这些手性取代吡唑基吡咯并[2,3-d]嘧啶可用作抑制Janus激酶家族蛋白酪氨酸激酶（JAKs）的药物，用于治疗炎症性疾病、骨髓增生性疾病和其他疾病。
• CHIRAL 1,3-DIARYLIMIDAZOLIUM SALT CARBENE PRECURSOR, SYNTHESIS METHOD THEREFOR, METAL SALT COMPOUND AND APPLICATION THEREOF
  申请人：Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

  公开号：EP3712132A1

  公开（公告）日：2020-09-23

  The present invention relates chiral 1, 3-diarylimidazole salt carbene precursors, their methods of preparation, particularly transition metal complexes and their use in chemical synthesis. An air and moisture stable chiral 1, 3-diarylimidazole carbene precursor Cu (I) complex has been prepared and applied to highly regio- and enantioselective Markovnikov hydroboration of unactivated terminal alkenes to form chiral boronic esters. Moreover, these new chiral NHCs can be potentially applied in various metal-catalyzed asymmetric transformations.

  本发明涉及手性 1，3-二咪唑盐碳烯前体及其制备方法，特别是过渡金属配合物及其在化学合成中的应用。本发明制备了一种空气和湿度稳定的手性 1，3-二咪唑碳烯前体 Cu (I) 复合物，并将其应用于未活化末端烯烃的高区域和对映选择性 Markovnikov 烃硼化反应，以形成手性硼酸酯。此外，这些新的手性 NHC 可用于各种金属催化的不对称转化。
• Processes for preparing 4-chloro-7H-pyrrolo[2,3-d]pyrimidine
  申请人：Incyte Holdings Corporation

  公开号：US10364248B2

  公开（公告）日：2019-07-30

  The present invention is related to processes for preparing 4-chloro-7H-pyrollo[2,3,-d]pyrimidine, and related synthetic intermediate compounds. 4-Chloro-7H-pyrrolo[2,3,-d]pyrimidine is an intermediate for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines, which are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

  本发明涉及制备 4-氯-7H-吡咯并[2,3,-d]嘧啶和相关合成中间体化合物的工艺。4-氯-7H-吡咯并[2,3,-d]嘧啶是制备手性取代的吡唑基吡咯并[2,3-d]嘧啶的中间体，可用作蛋白酪氨酸激酶 Janus Kinase 家族（JAKs）的抑制剂，用于治疗炎症性疾病、骨髓增生性疾病和其他疾病。
• Process for preparing a composition comprising an enantiomeric excess of greater than or equal to 90% of the (R)-enantiomer of a compound of formula III
  申请人：Incyte Holdings Corporation

  公开号：US10975085B2

  公开（公告）日：2021-04-13

  The present invention is related to processes for preparing a composition comprising (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile, and related synthetic intermediate compounds. This compound is useful as an inhibitor of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.

  本发明涉及制备包含(R)-3-(4-(7H-吡咯并[2,3-d]嘧啶-4-基)-1H-吡唑-1-基)-3-环戊基丙腈及相关合成中间体化合物的组合物的工艺。该化合物可作为蛋白酪氨酸激酶 Janus Kinase 家族（JAKs）的抑制剂，用于治疗炎症性疾病、骨髓增生性疾病和其他疾病。
• Chiral 1,3-diarylimidazolium salt carbene precursor, synthesis method therefor, metal salt compound and application thereof
  申请人：SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES

  公开号：US11345665B2

  公开（公告）日：2022-05-31

  Chiral 1, 3-diarylimidazole salt carbene precursors, their methods of preparation, particularly transition metal complexes and their use in chemical synthesis are provided. In particular, an air and moisture stable chiral 1, 3-diarylimidazole carbene precursor Cu (I) complex has been prepared and applied to highly regio- and enantioselective Markovnikov hydroboration of unactivated terminal alkenes to form chiral boronic esters. Moreover, these new chiral NHCs can be potentially applied in various metal-catalyzed asymmetric transformations.

  提供了手性 1，3-二咪唑盐碳烯前体及其制备方法，特别是过渡金属配合物及其在化学合成中的应用。特别是制备了一种空气和湿度稳定的手性 1，3-二咪唑碳烯前体 Cu (I) 复合物，并将其应用于未活化末端烯烃的高区域和对映选择性 Markovnikov 氢硼化合，以形成手性硼酸酯。此外，这些新的手性 NHC 可用于各种金属催化的不对称转化。