dimethyl 3-methyl-5-phenyl-1,4-dihydropyridazine-4,6-dicarboxylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: dimethyl 3-methyl-5-phenyl-1,4-dihydropyridazine-4,6-dicarboxylate
• 化学式: C₁₅H₁₆N₂O₄
• 分子量: 288.303
• InChiKey: HISOBBWFYHZUGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  77
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  dimethyl 3-methyl-5-phenyl-1,4-dihydropyridazine-4,6-dicarboxylate 在 potassium permanganate 作用下， 以 水 、 丙酮 为溶剂， 以88%的产率得到dimethyl 6-methyl-4-phenylpyridazine-3,5-dicarboxylate
  参考文献：
  名称：

  Synthesis of 4,6-Disubstituted Dimethyl Pyridazine-3,5-dicarboxylates

  摘要：

  Dimethyl pyridazine-3,5-dicarboxylates were synthesized by reaction of substituted 2-cyclopropenecarboxylates with methyl diazoacetate, followed by oxidation of the resulting 1,4-dihydropyridazine-4,6-dicarboxylates.

  DOI：

  10.1023/b:rujo.0000045199.21494.c7
• 作为产物：
  描述：

  2-甲基-3-苯基环丙基-2-烯-1-羧酸甲酯 、 重氮乙酸甲酯 以 N,N-二甲基甲酰胺 为溶剂， 反应 25.0h， 生成 dimethyl 5-methyl-3-phenyl-1,4-dihydropyridazine-4,6-dicarboxylate 、 dimethyl 3-methyl-5-phenyl-1,4-dihydropyridazine-4,6-dicarboxylate
  参考文献：
  名称：

  Synthesis of 4,6-Disubstituted Dimethyl Pyridazine-3,5-dicarboxylates

  摘要：

  Dimethyl pyridazine-3,5-dicarboxylates were synthesized by reaction of substituted 2-cyclopropenecarboxylates with methyl diazoacetate, followed by oxidation of the resulting 1,4-dihydropyridazine-4,6-dicarboxylates.

  DOI：

  10.1023/b:rujo.0000045199.21494.c7

文献信息

• Synthesis of 4,6-Disubstituted Dimethyl Pyridazine-3,5-dicarboxylates
  作者：M. E. Yakovlev、V. V. Razin

  DOI：10.1023/b:rujo.0000045199.21494.c7

  日期：2004.7

  Dimethyl pyridazine-3,5-dicarboxylates were synthesized by reaction of substituted 2-cyclopropenecarboxylates with methyl diazoacetate, followed by oxidation of the resulting 1,4-dihydropyridazine-4,6-dicarboxylates.