1-(4-(dimethylamino)phenyl)-4,4-dimethyl-1,3-pentanedione

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-(dimethylamino)phenyl)-4,4-dimethyl-1,3-pentanedione
• 英文别名: 1-(4-Dimethylaminophenyl)-4,4-dimethylpentane-1,3-dione；1-[4-(dimethylamino)phenyl]-4,4-dimethylpentane-1,3-dione
• 化学式: C₁₅H₂₁NO₂
• 分子量: 247.337
• InChiKey: OVWPUXDSJMTTOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(4-(dimethylamino)phenyl)-4,4-dimethyl-1,3-pentanedione 、 3-(4-dimethylamino-phenyl)-propenal 在 硼酸三丁酯 、 氧化硼 、 1,2,3,4-四氢喹啉 、 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.08h， 以8.8%的产率得到
  参考文献：
  名称：

  [EN] CURCUMIN ANALOGS
  [FR] ANALOGUES DE CURCUMINE

  摘要：

  本文提供了一些能够与淀粉样蛋白β（Aβ）相互作用并减弱铜诱导的Aβ交联的姜黄素类似物。本文还提供了使用这些化合物治疗阿尔茨海默病或相关疾病的方法。

  公开号：

  WO2014025808A1
• 作为产物：
  描述：

  频哪酮 、 4-二甲氨基苯甲酸乙酯 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 以70%的产率得到1-(4-(dimethylamino)phenyl)-4,4-dimethyl-1,3-pentanedione
  参考文献：
  名称：

  Aroyl ketone derivative, UV ray absorber comprising the same, and

  摘要：

  公开了一种由式(I)表示的新型酰基酮衍生物。其中R.sup.1代表具有1-24个碳原子的饱和或不饱和碳氢化合物基团，或具有1-24个碳原子的线性或支链烷氧基烷基或烯氧基烷基基团，具有1-24个碳原子的二烷基胺基团，Ar代表可能被一个或多个羟基，具有1-24个碳原子的烷氧基，具有1-24个碳原子的烯氧基，聚氧乙烯氧基，具有1-24个碳原子的单烷基或二烷基氨基，或α-亚甲二氧基基取代的苯或萘环，n表示1-4的整数。还公开了一种含有式(I)的酰基酮衍生物的紫外线吸收剂和化妆品组合物。本发明的酰基酮衍生物(I)可以提供出色的紫外线吸收效果，并具有出色的光稳定性，含有酰基酮衍生物(I)的紫外线吸收剂或化妆品组合物可以展现出优秀的防晒效果。

  公开号：

  US05191121A1

文献信息

• Aroyl ketone derivative, UV ray absorber comprising the same, and
  申请人：Kao Corporation

  公开号：US05191121A1

  公开（公告）日：1993-03-02

  A novel aroyl ketone derivative represented by formula (I) is disclosed. Ar(COCH.sub.2 COR.sup.1).sub.n (I) wherein R.sup.1 represents a saturated or unsaturated hydrocarbon group having 1-24 carbon atoms, or a linear or branched alkoxyalkyl or alkenyloxyalkyl group having 1-24 carbon atoms, dialkylamino group having 1-24 carbon atoms, Ar represents a benzene or naphthalene ring which may be substituted with one or more hydroxyl groups, alkoxy groups having 1-24 carbon atoms, alkenyloxy groups having 1-24 carbon atoms, polyoxyleneoxy groups, mono- or dialkyl amino groups having 1-24 carbon atoms, or .alpha.-methylenedioxy groups, and n denotes an integer of 1-4. An UV-ray absorber and cosmetic composition comprising the aroyl ketone derivative of formula (I) are also disclosed. Aroyl ketone derivative (I) of the present invention can provide an excellent UV-ray absorbing effect and has outstanding stability against light, and the UV-ray absorber or cosmetic composition containing the aroyl ketone derivative (I) can exhibit an excellent sunscreening effect.

  公开了一种由式(I)表示的新型酰基酮衍生物。其中R.sup.1代表具有1-24个碳原子的饱和或不饱和碳氢化合物基团，或具有1-24个碳原子的线性或支链烷氧基烷基或烯氧基烷基基团，具有1-24个碳原子的二烷基胺基团，Ar代表可能被一个或多个羟基，具有1-24个碳原子的烷氧基，具有1-24个碳原子的烯氧基，聚氧乙烯氧基，具有1-24个碳原子的单烷基或二烷基氨基，或α-亚甲二氧基基取代的苯或萘环，n表示1-4的整数。还公开了一种含有式(I)的酰基酮衍生物的紫外线吸收剂和化妆品组合物。本发明的酰基酮衍生物(I)可以提供出色的紫外线吸收效果，并具有出色的光稳定性，含有酰基酮衍生物(I)的紫外线吸收剂或化妆品组合物可以展现出优秀的防晒效果。
• β-Diketones bearing electron-donating chromophores and a novel β-triketone: synthesis and reversible fluorescence behavior
  作者：Xin Zhang、Zi-Chen Li、Ning Xu、Kai-Bo Li、Song Lin、Feng-Zhu Lu、Fu-Sheng Du、Fu-Mian Li

  DOI：10.1016/j.tetlet.2006.02.019

  日期：2006.4

  exist in both cis-enol and keto forms in solution, and their relative contents were determined by 1H NMR measurements. In contrast, for the β-triketone, only enol form was observed in a solution. A strong fluorescence quenching was observed for unsaturated diketones as compared with the saturated ones. These β-diketones displayed reversible photoinduced ketonization as revealed by UV–vis spectroscopy. The

  合成了带有4- N，N-二甲基氨基苯基取代基的饱和和不饱和β-二酮和新型β-三酮。这些β-二酮以顺式-烯醇式和酮式形式存在于溶液中，其相对含量由1确定。1 H NMR测量。相反，对于β-三酮，在溶液中仅观察到烯醇形式。与不饱和二酮相比，观察到强烈的荧光猝灭。这些β-二酮显示出可逆的光诱导酮化作用，如紫外可见光谱法所揭示。在紫外线照射下，饱和β-二酮的荧光发射逐渐减弱。这些饱和β-二酮的荧光发射因此可以基于酮-烯醇互变异构反应在烯醇形式“ ON”和酮形式“ OFF”之间可逆地切换。
• PHOTO-LATENT TITANIUM CATALYSTS
  申请人：Hintermann Tobias

  公开号：US20120220685A1

  公开（公告）日：2012-08-30

  The present invention provides a photolatent Ti-chelate catalyst formulation, comprising (i) at least one compound of the formula (I) wherein R 1 is C 1 -C 20 alkyl or C 2 -C 20 alkyl which is interrupted by one or more non-consecutive O-atoms; Y is formula (II) or optionally substituted phenyl; Y 1 is formula (III) or optionally substituted phenyl; Y 2 is formula (IV) or optionally substituted phenyl; Y 3 is formula (V) or optionally substituted phenyl; R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 independently of each other are hydrogen, halogen, optionally substituted C 1 -C 20 alkyl, or R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 independently of each other are optionally substituted C 6 -C 14 aryl, provided that only one of R 2 , R 3 , R 4 is hydrogen and only one of R 5 , R 6 , R 7 is hydrogen and only one of R 8 , R 9 , R 10 is hydrogen and only one of R 11 , R 12 , R 13 is hydrogen; and (ii) at least one chelate ligand compound of the formula IIa, IIb or IIc, wherein Y′ is formula (VI) or formula (VII); Y′ 1 is formula (VIII) or formula (IX); R′ 2 , R′ 3 , R′ 4 , R′ 5 , R′ 6 and R′ 7 independently of each other have on of the meanings as given for R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 ; and R′ 14 , R′ 15 and R′ 16 independently of each other have on of the meanings as given for R 14 , R 15 and R 16 .

  本发明提供了一种光潜性钛螯合催化剂配方，包括（i）至少一种式（I）化合物，其中R1是C1-C20烷基或被一个或多个不连续的氧原子打断的C2-C20烷基；Y是式（II）或可选取代的苯基；Y1是式（III）或可选取代的苯基；Y2是式（IV）或可选取代的苯基；Y3是式（V）或可选取代的苯基；R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12和R13独立地为氢、卤素、可选取代的C1-C20烷基，或R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12和R13独立地为可选取代的C6-C14芳基，但仅有R2、R3、R4中的一个为氢，仅有R5、R6、R7中的一个为氢，仅有R8、R9、R10中的一个为氢，仅有R11、R12、R13中的一个为氢；和（ii）至少一种螯合配体化合物，其为式IIa、IIb或IIc，其中Y'是式（VI）或式（VII）；Y'1是式（VIII）或式（IX）；R'2、R'3、R'4、R'5、R'6和R'7独立地具有R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12和R13所给出的含义；R'14、R'15和R'16独立地具有R14、R15和R16所给出的含义之一。
• 4,4-Dimethyl-1-phenylpentane-1,3-dione derivative and UV ray absorbent and cosmetic containing the same
  申请人：KAO CORPORATION

  公开号：EP0504844A2

  公开（公告）日：1992-09-23

  A 4,4-Dimethyl-1-phenylpentane-1,3-dione derivatives represented by the following formula (1): wherein all symbols are defined in the disclosure, is disclosed. An ultraviolet ray absorbent and a cosmetic comprising the derivative are also disclosed. The derivative of the present invention have excellent ultraviolet ray absorbing performance and superior light stability, and the ultraviolet ray absorbent and cosmetic comprising the derivative have excellent effect to prevent sunburn.

  由下式（1）代表的 4,4-二甲基-1-苯基-1,3-戊二衍生物： 其中所有符号均在本公开中定义。本发明还公开了一种紫外线吸收剂和一种含有该衍生物的化妆品。本发明的衍生物具有极佳的紫外线吸收性能和优异的光稳定性，包含该衍生物的紫外线吸收剂和化妆品具有极佳的防晒效果。
• Photo-latent titanium catalysts
  申请人：Hintermann Tobias

  公开号：US10207261B2

  公开（公告）日：2019-02-19

  The present invention provides a photolatent Ti-chelate catalyst formulation, comprising (i) at least one compound of the formula (I) wherein R1 is C1-C20alkyl or C2-C20alkyl which is interrupted by one or more non-consecutive O-atoms; Y is formula (II) or optionally substituted phenyl; Y1 is formula (III) or optionally substituted phenyl; Y2 is formula (IV) or optionally substituted phenyl; Y3 is formula (V) or optionally substituted phenyl; R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 independently of each other are hydrogen, halogen, optionally substituted C1-C20alkyl, or R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 independently of each other are optionally substituted C6-C14aryl, provided that only one of R2, R3, R4 is hydrogen and only one of R5, R6, R7 is hydrogen and only one of R8, R9, R10 is hydrogen and only one of R11, R12, R13 is hydrogen; and (ii) at least one chelate ligand compound of the formula IIa, IIb or IIc, wherein Y′ is formula (VI) or formula (VII); Y′1 is formula (VIII) or formula (IX); R′2, R′3, R′4, R′5, R′6 and R′7 independently of each other have on of the meanings as given for R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13; and R′14, R′15 and R′16 independently of each other have on of the meanings as given for R14, R15 and R16.

  本发明提供了一种光螯合钛催化剂配方，包括(i)至少一种式(I)化合物 其中R1是被一个或多个非连续O原子打断的C1-C20烷基或C2-C20烷基；Y是式(II)或任选取代的苯基；Y1是式(III)或任选取代的苯基；Y2是式(IV)或任选取代的苯基；Y3是式(V)或任选取代的苯基；R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12 和 R13 相互独立地是氢、卤素、任选取代的 C1-C20 烷基，或 R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12 和 R13 相互独立地是氢、卤素、任选取代的 C1-C20 烷基、R12 和 R13 相互独立地为任选取代的 C6-C14 芳基，条件是 R2、R3、R4 中只有一个是氢，R5、R6、R7 中只有一个是氢，R8、R9、R10 中只有一个是氢，R11、R12、R13 中只有一个是氢；和(ii)至少一种式 IIa、IIb 或 IIc 的螯合配体化合物，其中 Y′为式(VI)或式(VII)；Y′1 为式(VIII)或式(IX)R′2、R′3、R′4、R′5、R′6 和 R′7 相互独立地具有 R2、R3、R4、R5、R6、R7、R8、R9、R10、R11、R12 和 R13 所给出的含义；R′14、R′15 和 R′16 相互独立地具有 R14、R15 和 R16 所具有的含义。