(E,E)-2,2-dimethylnona-4,6-dien-3-one

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (E,E)-2,2-dimethylnona-4,6-dien-3-one
• 英文别名: (4E,6E)-2,2-dimethylnona-4,6-dien-3-one
• 化学式: C₁₁H₁₈O
• 分子量: 166.263
• InChiKey: VYKQYSXYRJLIBR-BLHCBFLLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E,E)-2,2-dimethylnona-4,6-dien-3-one 、 联硼酸频那醇酯 在 CuF(PPh₃)₃*2MeOH 、 cyclopenta-1,3-diene;dicyclohexyl-[(1R)-1-(2-diphenylphosphanylcyclopenta-1,4-dien-1-yl)ethyl]phosphane;ethanol;iron(2+) 、 异丙醇 作用下， 以 四氢呋喃 、 环己烷 为溶剂， 反应 15.0h， 以85%的产率得到(Z,R)-2,2-dimethyl-7-(tetramethyl-1,3,2-dioxaborolan-2-yl)dec-4-en-3-one
  参考文献：
  名称：

  对映选择性铜催化的1,6-硼酸酯可切换合成Z-均烯丙基硼酸酯和E-烯丙基硼酸酯

  摘要：

  描述了（E，E）-α，β，γ，δ-不饱和酮的对映选择性Cu催化的1,6-硼酸酯，它使对映体硼酸酯具有高对映体纯度和出乎意料的高Z选择性。通过改变溶剂，可以改变结果，得到E-烯丙基硼酸盐。

  DOI：

  10.1002/chem.201801804
• 作为产物：
  描述：

  频哪酮 、 反式-2-戊烯醛 在 lithium diisopropyl amide 、 三甲基氯硅烷 作用下， 以 四氢呋喃 为溶剂， 反应 0.78h， 以70%的产率得到(E,E)-2,2-dimethylnona-4,6-dien-3-one
  参考文献：
  名称：

  对映选择性铜催化的1,6-硼酸酯可切换合成Z-均烯丙基硼酸酯和E-烯丙基硼酸酯

  摘要：

  描述了（E，E）-α，β，γ，δ-不饱和酮的对映选择性Cu催化的1,6-硼酸酯，它使对映体硼酸酯具有高对映体纯度和出乎意料的高Z选择性。通过改变溶剂，可以改变结果，得到E-烯丙基硼酸盐。

  DOI：

  10.1002/chem.201801804

文献信息

• METHODS OF ANALYZING POLYNUCLEOTIDES EMPLOYING ENERGY TRANSFER DYES
  申请人：Lee G. Linda

  公开号：US20070154926A1

  公开（公告）日：2007-07-05

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• ENERGY TRANSFER DYES WITH ENHANCED FLUORESCENCE
  申请人：Lee G. Linda

  公开号：US20070154927A1

  公开（公告）日：2007-07-05

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• METHODS OF LABELING POLYNUCLEOTIDES WITH ENERGY TRANSFER DYES
  申请人：Lee Linda G.

  公开号：US20080268509A1

  公开（公告）日：2008-10-30

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• Oligonucleotides and Analogs Labeled with Energy Transfer Dyes
  申请人：Lee Linda G.

  公开号：US20120172583A1

  公开（公告）日：2012-07-05

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• US7399854B2
  申请人：——

  公开号：US7399854B2

  公开（公告）日：2008-07-15