4-[3-(4-fluoro-phenyl)-5H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-2-yl]-benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[3-(4-fluoro-phenyl)-5H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-2-yl]-benzenesulfonamide
• 英文别名: 2-(4-(aminosulphonyl)phenyl)-3-(4-fluorophenyl)-5H-pyrazolo[5,1-b][1,3]benzoxazine；3-(4-Fluorophenyl)-2-(4-(aminosulphonyl)phenyl)-5H-pyrazolo[1,5-a][3,1]benzoxazine；4-[3-(4-fluorophenyl)-5H-pyrazolo[1,5-a][3,1]benzoxazin-2-yl]benzenesulfonamide
• 化学式: C₂₂H₁₆FN₃O₃S
• 分子量: 421.452
• InChiKey: KOHDDTDCXIMUKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  30
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  95.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对羧基苯磺酰胺 在 草酰氯 、 potassium carbonate 、 一水合肼 、 溶剂黄146 、 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 4-[3-(4-fluoro-phenyl)-5H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-2-yl]-benzenesulfonamide
  参考文献：
  名称：

  Synthesis of 4,5-Diaryl-1H-pyrazole-3-ol Derivatives as Potential COX-2 Inhibitors

  摘要：

  4,5-Diaryl-1H-pyrazole-3-ol was utilized as a versatile template to synthesize several classes of compounds such as pyrazolo-oxazines 7, pyrazolo-benzooxazines 9, pyrazolo-oxazoles 10, and its analogues 11a-c as potential COX-2 inhibitors. Compounds 11b,c were successfully synthesized with use of pyridinium p-toluenesulfonate mediated cyclization of the ketal intermediate. Diaryl-pyrazolo-benzooxazepine analogues were synthesized by using Cu-mediated cyclization of the O-alkylated arylbromide intermediate. Arylsulfonamides were synthesized efficiently on a large scale with 4-[4-(4-fluorophenyl)-5-hydroxy-2H-pyrazol-3-yl]benzenesulfonamide 31 template readily synthesized from commercially available 4-sulfamoyl benzoic acid 29. The structure of a representative compound from each class was confirmed by X-ray crystallography. Selected compounds tested for inhibitory activity against COX-1 and COX-2 enzymes showed good selectivity for COX-2 versus COX-1 enzyme.

  DOI：

  10.1021/jo049264k

文献信息

• SULFONYLPHENYLPYRAZOLE COMPOUNDS USEFUL AS COX-2 INHIBITORS
  申请人：ABBOTT LABORATORIES

  公开号：EP1206474B1

  公开（公告）日：2004-05-26