Ethyl 2-methoxy-4-methyl-6-phenyl-1,4-dihydropyrimidine-5-carboxylate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Ethyl 2-methoxy-4-methyl-6-phenyl-1,4-dihydropyrimidine-5-carboxylate
• 英文别名: ethyl 2-methoxy-4-methyl-6-phenyl-1,4-dihydropyrimidine-5-carboxylate
• 化学式: C₁₅H₁₈N₂O₃
• 分子量: 274.32
• InChiKey: RREDUIQYJLLMPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  苯甲酰乙酸乙酯 、 乙醛 、 O-甲基异脲 在 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Ethyl 2-methoxy-4-methyl-6-phenyl-1,4-dihydropyrimidine-5-carboxylate 、 Ethyl 2-methoxy-4-methyl-6-phenyl-1,4-dihydropyrimidine-5-carboxylate
  参考文献：
  名称：

  Oxidative Dehydrogenation of Dihydropyrimidinones and Dihydropyrimidines

  摘要：

  A mild, practical procedure for oxidative dehydrogenation with catalytic amounts of a Cu salt, K2CO3, and tert-butylhydroperoxide (TBHP) as a terminal oxidant has been developed. This oxidation procedure is generally applicable to dihydropyrimidinones and most dihydropyrimidines.

  DOI：

  10.1021/ol051879w

文献信息

• Oxidative Dehydrogenation of Dihydropyrimidinones and Dihydropyrimidines
  作者：Kana Yamamoto、Ye Grace Chen、Frédéric G. Buono

  DOI：10.1021/ol051879w

  日期：2005.10.1

  A mild, practical procedure for oxidative dehydrogenation with catalytic amounts of a Cu salt, K2CO3, and tert-butylhydroperoxide (TBHP) as a terminal oxidant has been developed. This oxidation procedure is generally applicable to dihydropyrimidinones and most dihydropyrimidines.