8-quinolinecarboxaldehyde selenosemicarbazone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-quinolinecarboxaldehyde selenosemicarbazone
• 化学式: C₁₁H₁₀N₄Se
• 分子量: 277.187
• InChiKey: KWINBLGXUUHQAO-VGOFMYFVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.37
• 重原子数：
  16.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.3
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  potassium tetrachloropalladate(II) 、 8-quinolinecarboxaldehyde selenosemicarbazone 以 二甲基亚砜 为溶剂， 反应 1.0h， 以66.4%的产率得到8-quinolinecarboxaldehyde selenosemicarbazonato-N,N,Se-chloropalladium(II)
  参考文献：
  名称：

  Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes

  摘要：

  New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.

  DOI：

  10.1007/s00706-014-1197-6
• 作为产物：
  描述：

  喹啉-8-甲醛 、 氨基硒脲 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以85%的产率得到8-quinolinecarboxaldehyde selenosemicarbazone
  参考文献：
  名称：

  Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes

  摘要：

  New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.

  DOI：

  10.1007/s00706-014-1197-6