sargaquinoic acid | 70363-87-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: sargaquinoic acid
• 英文别名: (2Z,6E,10E)-6,10-dimethyl-12-(5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)-2-(4-methylpent-3-enyl)dodeca-2,6,10-trienoic acid
• CAS: 70363-87-0
• 化学式: C₂₇H₃₆O₄
• 分子量: 424.58
• InChiKey: IKUIJYZNRMQNBM-FWXQPYBBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  31
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  sargaquinoic acid 、 三甲基硅烷化重氮甲烷 以 甲醇 、 正己烷 为溶剂， 反应 0.17h， 以24%的产率得到methyl (2Z,6E,10E)-6,10-dimethyl-12-(5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)-2-(4-methylpent-3-enyl)dodeca-2,6,10-trienoate
  参考文献：
  名称：

  Antibacterial Quinone Metabolites from the Brown Alga,Sargassum sagamianum

  摘要：

  从褐藻马尾藻中分离出了抗菌的马尾葵酸衍生物。这些醌类代谢物的结构通过核磁共振和质谱以及与已发表数据的比较得到了证实。本文简要讨论了它们的结构与抗菌活性之间的关系。

  DOI：

  10.1246/bcsj.81.1125
• 作为产物：
  描述：

  sargahydroquinoic acid 在 chromium(VI) oxide 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 以86%的产率得到sargaquinoic acid
  参考文献：
  名称：

  Anti-platelet Aggregation and Anti-thrombotic Effects of Marine Natural Products Sargahydroquinoic Acid and Sargaquinoic Acid

  摘要：

  E-mail: [e-mail] June 18, 2013, Accepted July 16, 2013Key Words : Marine natural products, Anti-platelet aggregation, Anti-thrombotic effects, Sargahydroquinoicacid, Sargaquinoic acidPlatelets circulate in blood and their activity is regulatedby nitric oxide (NO) and prostaglandin I

  DOI：

  10.5012/bkcs.2013.34.10.3121

文献信息

• NEUROPROTECTIVE COMPOSITIONS AND METHODS
  申请人：Simon James E.

  公开号：US20120136047A1

  公开（公告）日：2012-05-31

  This disclosure concerns novel methods for preventing or treating neurological or neurodegenerative diseases or disorders by using kombo butter acid enriched extracts derived from the seeds of African nutmeg, the main active compounds isolated from the extracts, namely sargaquinoic acid, sargachromenol, and sargahydroquinoic acid, or synthetic analogs or derivatives thereof, as neuroprotective agents. The methods for preparing the kombo butter or kombo butter acid extracts and the methods for isolating and purifying the active compounds and for preparing their acetylated derivatives are also described.
• ANTIOXIDANT COMPOSITION COMPRISING SARGASSUM SERRATIFOLIUM EXTRACT OR FRACTION THEREOF AS ACTIVE INGREDIENT
  申请人：PUKYONG NATIONAL UNIVERSITY INDUSTRY-UNIVERSITY COOPERATION FOUNDATION

  公开号：US20190142885A1

  公开（公告）日：2019-05-16

  The present invention relates to an antioxidant composition and, more specifically, to an antioxidant composition including a Sargassum serratifolium extract or a fraction thereof as an active ingredient, in which the antioxidant composition is a useful material (substance) that can be added to medicines, cosmetics, foods, animal feeds, and the like. The present invention also relates to a pharmaceutical composition for preventing or treating eye diseases, a food composition for alleviating eye diseases, and a health functional food, each of which includes a Sargassum serratifolium extract or a compound separated therefrom as an active ingredient.
• US7371413B2
  申请人：——

  公开号：US7371413B2

  公开（公告）日：2008-05-13
• [EN] NEUROPROTECTIVE COMPOSITIONS AND METHODS<br/>[FR] COMPOSITIONS NEUROPROTECTRICES ET MÉTHODES CORRESPONDANTES
  申请人：UNIV RUTGERS

  公开号：WO2010111584A1

  公开（公告）日：2010-09-30

  This disclosure concerns novel methods for preventing or treating neurological or neurodegenerative diseases or disorders by using kombo butter acid enriched extracts derived from the seeds of African nutmeg, the main active compounds isolated from the extracts, namely sargaquinoic acid, sargachromenol, and sargahydroquinoic acid, or synthetic analogs or derivatives thereof, as neuroprotective agents. The methods for preparing the kombo butter or kombo butter acid extracts and the methods for isolating and purifying the active compounds and for preparing their acetylated derivatives are also described.
• Antibacterial Quinone Metabolites from the Brown Alga,<i>Sargassum sagamianum</i>
  作者：Shohei Horie、Shinsuke Tsutsumi、Yuuki Takada、Junji Kimura

  DOI：10.1246/bcsj.81.1125

  日期：2008.9.15

  Antibacterial sargaquinoic acid derivatives were isolated from the brown alga Sargassum sagamianum. The structures of these quinone metabolites were confirmed by NMR and mass spectroscopy, and by comparison with published data. The relationship between their structures and antibacterial activities are briefly discussed.

  从褐藻马尾藻中分离出了抗菌的马尾葵酸衍生物。这些醌类代谢物的结构通过核磁共振和质谱以及与已发表数据的比较得到了证实。本文简要讨论了它们的结构与抗菌活性之间的关系。