2-[(1R,4R)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-en-1-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[(1R,4R)-4,7-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-1-yl]prop-2-en-1-ol
• 化学式: C₁₅H₂₄O
• 分子量: 220.35
• InChiKey: CZSSHKCZSDDOAH-CMAYJEJSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• NUCLEOTIDE SEQUENCES ENCODING ENZYMES IN BIOSYNTHESIS OF DIHYDROARTEMISINIC ACID
  申请人：Teoh Keat (Thomas) H.

  公开号：US20090265804A1

  公开（公告）日：2009-10-22

  Isolated nucleic acid molecules cloned from Artemisia annua encode artemisinic aldehyde double bond reductase and artemisinic/dihydroartemisinic aldehyde dehydrogenase. Artemisinic aldehyde double bond reductase enzymatically reduces artemisinic aldehyde to dihydroartemisinic aldehyde. Artemisinic/dihydroartemisinic aldehyde dehydrogenase enzymatically oxidizes dihydroartemisinic aldehyde to dihydroartemisinic acid and artemisinic aldehyde to artemisinic acid. The nucleic acid molecules, and the enzymes encoded thereby, may be used in processes to produce dihydroartemsinic aldehyde, dihydroartemisinic acid or artemisinic acid in a host cell. Dihydroartemisinic acid is a late precursor to the a antimalarial compound artemisinin.

  从青蒿中克隆的孤立核酸分子编码青蒿烯醛双键还原酶和青蒿烯醛/二氢青蒿烯醛脱氢酶。青蒿烯醛双键还原酶通过酶促反应将青蒿烯醛还原为二氢青蒿烯醛。青蒿烯醛/二氢青蒿烯醛脱氢酶通过酶促反应将二氢青蒿烯醛氧化为二氢青蒿酸和将青蒿烯醛氧化为青蒿酸。这些核酸分子及其编码的酶可用于在宿主细胞中生产二氢青蒿烯醛、二氢青蒿酸或青蒿酸的过程中。二氢青蒿酸是抗疟疾化合物青蒿素的晚期前体。
• NUCLEOTIDE SEQUENCE ENCODING AN ALCOHOL DEHYDROGENASE FROM ARTEMISIA ANNUA AND USES THEREOF
  申请人：Polichuk Devin

  公开号：US20110162097A1

  公开（公告）日：2011-06-30

  An isolated nucleic acid molecule cloned from Artemisia annua encodes an alcohol dehydrogenase (Adh1). Artemisia annua Adh1 enzymatically oxidizes artemisinic alcohol to artemisinic aldehyde. The nucleic acid molecule, and the enzyme encoded thereby, may be used in processes to produce artemisinic aldehyde, dihydroartemsinic aldehyde, artemisinic acid and/or dihydroartemisinic acid in a host cell. Artemisinic aldehyde, dihydroartemisinic aldehyde, artemisinic acid and/or dihydroartemisinic acid can be chemically converted to the antimalarial compound artemisinin.

  从青蒿中克隆的孤立核酸分子编码酒精脱氢酶（Adh1）。青蒿Adh1酶可将青蒿醇酶促氧化为青蒿醛。该核酸分子及其编码的酶可用于在宿主细胞中生产青蒿醛，二氢青蒿醛，青蒿酸和/或二氢青蒿酸的过程中。青蒿醛，二氢青蒿醛，青蒿酸和/或二氢青蒿酸可被化学转化为抗疟疾化合物青蒿素。
• US8207402B2
  申请人：——

  公开号：US8207402B2

  公开（公告）日：2012-06-26