2-(5-Methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)quinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-(5-Methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)quinoline
• 化学式: C₁₅H₁₇N₃
• 分子量: 239.32
• InChiKey: XZDDYBKLXPTCCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  19.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NOVEL 2,5-DIAZABICYCLO(2.2.1)HEPTANE DERIVATIVES
  申请人：NEUROSEARCH A/S

  公开号：EP1368348A1

  公开（公告）日：2003-12-10
• [EN] NOVEL 2,5-DIAZABICYCLO[2.2.1]HEPTANE DERIVATIVES<br/>[FR] NOUVEAUX DERIVES DE 2,5-DIAZABICYCLO[2.2.1]HEPTANE
  申请人：NEUROSEARCH AS

  公开号：WO2002070522A1

  公开（公告）日：2002-09-12

  The present invention relates to novel 2,5-diazabicyclo[2.2.1]heptane derivatives, which are found to be potent modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances as represented by formula (I) wherein R1 represents hydrogen, an alkyl group, a cycloalkyl group, an alkenyl group or an aralkyl group; and R2 represents a bicyclic carbocyclic group or a bicyclic heterocyclic group.