Dimethyl-[2-(1,7,7-trimethyl-2-phenyl-bicyclo[2.2.1]hept-2-yloxy)-ethyl]-amine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: Dimethyl-[2-(1,7,7-trimethyl-2-phenyl-bicyclo[2.2.1]hept-2-yloxy)-ethyl]-amine
• 英文别名: N,N-dimethyl-2-[(1,7,7-trimethyl-2-phenyl-2-bicyclo[2.2.1]heptanyl)oxy]ethanamine
• 化学式: C₂₀H₃₁NO
• 分子量: 301.5
• InChiKey: QOBGWWQAMAPULA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• The use of( a) bicycloheptane derivative(s)
  申请人：EGIS GYOGYSZERGYAR RT.

  公开号：EP0694299A1

  公开（公告）日：1996-01-31

  The subject matter of the invention is the use of [a] bicycloheptane derivative(s) of formula wherein Rrepresents a phenyl or a benzyl group, R₁ and R₂ ,which may be the same or different stand for straight or branched chained alkyl groups or one of R₁ and R₂ is hydrogen and the other is a straight or branched chained alkyl group, Adenotes a straight or branched chained alkylene group and ∼represents a valence bond, and [an] N-oxide(s) as well as [an] optical isomer(s) thereof and mixtures of the optical isomers and [an] acid addition salt(s) and quaternary ammonium derivative(s) of the bicycloheptane derivatives of formula I as well as [an] optical isomer(s) thereof and mixtures of the optical isomers for preparing medicaments for the treatment of diseases and disorders which are connected with the influence on the peripheral cholecystokinin (CCK) system.

  本发明的主题是使用式[a]双环庚烷衍生物 式中 R 代表苯基或苄基、 R₁ 和 R₂，可以相同或不同，代表直链或支链烷基，或 R₁ 和 R₂ 中的一个是氢，另一个是直链或支链烷基、 表示直链或支链亚烷基，以及 ∼代表价键、 式 I 的双环庚烷衍生物的[一种]N-氧化物及其[一种]光学异构体和光学异构体的混合物以及[一种]酸加成盐和季铵衍生物及其[一种]光学异构体和光学异构体的混合物，用于制备治疗与影响外周胆囊收缩素（CCK）系统有关的疾病和失调的药物。
• FMO3 inhibitors for treating pain
  申请人：Akron Molecules GmbH

  公开号：EP2674161A1

  公开（公告）日：2013-12-18

  The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.

  本发明涉及治疗疼痛和相关疾病的新疗法，以及用于上述疗法的药物化合物。
• Method for treating stress or tension
  申请人：——

  公开号：US20040082665A1

  公开（公告）日：2004-04-29

  A method of treating stress and/or tension in a mammal by administering to the mammal an effective amount of 1,7,7-trimethyl-bicyclo[2.2.1]heptane derivative of Formula I 1 wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof.

  一种治疗哺乳动物压力和/或紧张的方法，通过向哺乳动物施用有效量的式 I 的 1,7,7-三甲基-双环[2.2.1]庚烷衍生物 1 其中 R 为氢或甲基，或其药学上可接受的盐。
• HIGH PURITY (1R, 2S, 4R)-(-)-2-[(2'-(N,N-DIMETHYLAMINO)-ETHOXY)]-2-[PHENYL]-1,7,7-TRI-[METHYL]-BICYCLO[2.2.1]HEPTANE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, PROCESS FOR THE PREPARATION OF THESE COMPOUNDS AND MEDICAMENTS CONTAINING THEM.
  申请人：EGIS GYOGYSZERGYAR RT.

  公开号：EP1177167B1

  公开（公告）日：2003-10-22
• TREATMENT OF OBSESSIVE COMPULSIVE DISORDER
  申请人：ORION CORPORATION

  公开号：EP1345599A1

  公开（公告）日：2003-09-24