反式-1-对甲苯磺酰基-4-羟基-L-脯氨酸甲酯 | 16257-57-1

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 脯氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 反式-1-对甲苯磺酰基-4-羟基-L-脯氨酸甲酯
• 中文别名: 4-羟基-1-[(4-甲基苯基)磺酰基]-2-吡咯烷羧酸甲酯
• 英文名称: Methyl 4-hydroxy-1-tosylpyrrolidine-2-carboxylate
• 英文别名: methyl 4-hydroxy-1-(4-methylphenyl)sulfonylpyrrolidine-2-carboxylate
• CAS: 16257-57-1
• 化学式: C₁₃H₁₇NO₅S
• 分子量: 299.34
• InChiKey: XUMMBVXGIOJOPC-UHFFFAOYSA-N

物化性质

• 熔点：
  97-99°C
• 沸点：
  455.3±55.0 °C(Predicted)
• 密度：
  1.373±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  92.3
• 氢给体数：
  1
• 氢受体数：
  6

安全信息

• 危险等级：
  IRRITANT
• 海关编码：
  2933990090

文献信息

• NOVEL L-PROLINE SULFONAMIDE DERIVATIVES COMPRISING PYRAZOLO[4,3- E]TETRAZOLO[4,5-B][1,2,4]TRIAZINE SYSTEM, METHOD OF MANUFACTURING THEREOF, USES THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：UNIWERSYTET MEDYCZNY W BIALYMSTOKU

  公开号：US20220017529A1

  公开（公告）日：2022-01-20

  The subject matter of the invention relates to novel sulfonamide derivatives of 7-methyl-5-phenyl-pyrazolo[4,3-c]tetrazolo[4,5-b] [1,2,4]triazine comprising L-proline or 4-hydroxy-L-proline in the sulfonamide group. The novel compounds exhibit cytostatic activity against gastric cancer cell (AGS) and colorectal cancer cell (DLD-1 and HT-29) lines and may be used as novel medicaments which have anticancer action. The subject matter of the invention also relates to a method of manufacturing such derivatives, as well as uses thereof and a pharmaceutical composition comprising the same.
• [EN] TRPV4 ANTAGONISTS<br/>[FR] ANTAGONISTES DE TRPV4
  申请人：GLAXOSMITHKLINE LLP

  公开号：WO2011091407A1

  公开（公告）日：2011-07-28

  The present invention relates to diazabicyclo[2.2.1]hept-2-yl analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.