7-[2-(5-triisopropylsilyloxy-carbonyl-pentyl)-3-isopropyl-6-oxo-cyclohexyl]-7-hydroxy-heptenoic acid methyl ester

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7-[2-(5-triisopropylsilyloxy-carbonyl-pentyl)-3-isopropyl-6-oxo-cyclohexyl]-7-hydroxy-heptenoic acid methyl ester
• 英文别名: methyl 7-hydroxy-7-[(1R,2R,3R)-6-oxo-2-[6-oxo-6-tri(propan-2-yl)silyloxyhexyl]-3-propan-2-ylcyclohexyl]heptanoate
• 化学式: C₃₂H₆₀O₆Si
• 分子量: 568.91
• InChiKey: VCFVELKFONVFTM-AIUJIXCKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.01
• 重原子数：
  39
• 可旋转键数：
  20
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  7-氧代庚酸甲酯 、 4-异丙基环己-2-烯-1-酮 、 triisopropylsilyl 6-iodohexanoate 在 三甲基氯硅烷 、 甲基锂 、 lithium methyl(cyano)cuprate 、 1,2-二溴乙烷 、 锌 作用下， 生成 7-[2-(5-triisopropylsilyloxy-carbonyl-pentyl)-3-isopropyl-6-oxo-cyclohexyl]-7-hydroxy-heptenoic acid methyl ester
  参考文献：
  名称：

  Cuprate-catalyzedThree-Component Couplings of Functionalized Organozinc Reagents

  摘要：

  AbstractOrganozinc reagents FG‐(CH2)nZnX containing electrophilic centers (FG) upon conversion to their corresponding zincates (FG‐(CH2)nZnMe2Li) and in the presence of 5–8 mol % MeCu(CN)Li, undergo 1,4‐additions to cyclic conjugated enones. The intermediate zinc enolates can be trapped with aldehydes to afford products of three‐component couplings.

  DOI：

  10.1002/jccs.199700001

文献信息

• Cuprate-<i>catalyzed</i>Three-Component Couplings of Functionalized Organozinc Reagents
  作者：Bruce H. Lipshutz、Tim Gross、Daniel J. Buzard、Raymond Tirado

  DOI：10.1002/jccs.199700001

  日期：1997.2

  AbstractOrganozinc reagents FG‐(CH2)nZnX containing electrophilic centers (FG) upon conversion to their corresponding zincates (FG‐(CH2)nZnMe2Li) and in the presence of 5–8 mol % MeCu(CN)Li, undergo 1,4‐additions to cyclic conjugated enones. The intermediate zinc enolates can be trapped with aldehydes to afford products of three‐component couplings.