methyleneisopropyl ketone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyleneisopropyl ketone
• 英文别名: ethenylethyl ketone；methylallyl ketone；vinylethyl ketone；2-But-3-enyl ketone；3,5-dimethylhepta-1,6-dien-4-one
• 化学式: C₉H₁₄O
• 分子量: 138.21
• InChiKey: YYWOXPGHTYRUMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  一氧化碳 、 1-氯-2-丁烯 在 Fe₆₄/Ni₃₆ anode 2,2'-联吡啶 、 tetrabutylammonium tetrafluoroborate 、 iron(II) chloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以35%的产率得到2,6-辛二烯
  参考文献：
  名称：

  New electrochemical synthesis of ketones from organic halides and carbon monoxide

  摘要：

  不锈钢阳极的解体提供了具有催化活性的镍物质，使得在二吡啶和一氧化碳的存在下，通过电解DMF中的有机卤化物能够高效合成酮类化合物。

  DOI：

  10.1039/c39950002331

文献信息

• BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF
  申请人：Gangjee Aleem

  公开号：US20100010016A1

  公开（公告）日：2010-01-14

  The present invention provides bicyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.

  本发明提供了具有抗有丝分裂活性、抗多药耐药活性（例如P-糖蛋白抑制作用）和抗肿瘤活性的双环化合物、药用可接受盐、前药、溶剂化合物和水合物，其能够抑制紫杉醇敏感和耐药肿瘤细胞。还提供了利用这些化合物治疗肿瘤细胞和抑制癌细胞有丝分裂的方法。
• TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF
  申请人：Gangjee Aleem

  公开号：US20090082374A1

  公开（公告）日：2009-03-26

  The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.

  本发明提供了三环化合物、药学上可接受的盐、前药、溶剂或其水合物，具有抗有丝分裂活性、抗多药耐药活性，例如P-糖蛋白抑制作用和抗肿瘤活性，并且抑制紫杉醇敏感和耐药肿瘤细胞。同时，还提供了利用这些化合物治疗肿瘤细胞和抑制癌细胞有丝分裂的方法。
• BINDER COMPOSITION FOR NON-AQUEOUS SECONDARY BATTERY ELECTRODE
  申请人：Kinoshita Sachiko

  公开号：US20120095131A1

  公开（公告）日：2012-04-19

  Disclosed is a binder composition for a non-aqueous secondary battery electrode, which enables the production of a non-aqueous secondary battery that has excellent adhesion to a current collector or an electrode and can retain a high electric discharge capacity even when charge and discharge are repeated or under a high-temperature environment produced as a result of the generation of heat. Specifically disclosed is a binder composition for a non-aqueous secondary battery electrode, which comprises functional group-containing crosslinked resin microparticles produced by polymerizing the following components (A) to (C): (A) at least one monomer selected from the group consisting of (a) a monomer having one ethylenically unsaturated group per molecule and also having a monofunctional or polyfunctional epoxy group, (b) a monomer having one ethylenically unsaturated group per molecule and also having a monofunctional or polyfunctional amide group, and (c) a monomer having one ethylenically unsaturated group per molecule and also having a monofunctional or polyfunctional hydroxy group; (B) at least one monomer selected from the group consisting of (d) a monomer having one ethylenically unsaturated group per molecule and also having an alkoxysilyl group and (e) a monomer having at least two ethylenically unsaturated groups per molecule; and (C) (k) a monomer which has an ethylenically unsaturated group and is different from the monomers (a) to (e).

  本发明公开了一种用于非水性二次电池电极的粘合剂组合物，该组合物能够生产出具有优异附着力的非水性二次电池，该电池能够在充放电重复或因产生热而产生高温环境下保持高电放电容量。具体而言，本发明公开了一种用于非水性二次电池电极的粘合剂组合物，该组合物包括通过聚合以下组分（A）至（C）制备的含有功能性基团的交联树脂微粒：（A）选自以下组中的至少一种单体，所述组包括（a）每个分子具有一个乙烯基不饱和基团并且还具有单官能或多官能环氧基团的单体，（b）每个分子具有一个乙烯基不饱和基团并且还具有单官能或多官能酰胺基团的单体，以及（c）每个分子具有一个乙烯基不饱和基团并且还具有单官能或多官能羟基团的单体；（B）选自以下组中的至少一种单体，所述组包括（d）每个分子具有一个乙烯基不饱和基团并且还具有烷氧基基团的单体和（e）每个分子具有至少两个乙烯基不饱和基团的单体；以及（C）（k）一种具有乙烯基不饱和基团且与单体（a）至（e）不同的单体。
• Substituted Cyclopenta Pyrimidine Bicyclic Compounds Having Antitmitotic And/Or Antitumor Activity And Methods Of Use Thereof
  申请人：Gangjee Aleem

  公开号：US20140303188A1

  公开（公告）日：2014-10-09

  The present invention provides substituted cyclopenta and cyclopentyl pyrimidine bicyclic compounds of Formula III, and 5,6-saturated and unsaturated and pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.

  本发明提供了式III的取代环戊基和环戊基嘧啶双环化合物，以及5,6-饱和和不饱和的药物可接受的盐、前药、溶剂化合物和水合物，具有抗有丝分裂活性、抗多药耐药活性，例如P-糖蛋白抑制作用和抗肿瘤活性，并且抑制紫杉醇敏感和耐药的肿瘤细胞。还提供了利用这些化合物治疗肿瘤细胞和抑制癌细胞有丝分裂的方法。
• Tricyclic Compounds Having Antimitotic and/or Antitumor Activity and Methods of Use Thereof
  申请人：Gangjee Aleem

  公开号：US20130096146A1

  公开（公告）日：2013-04-18

  The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for example P-glycoprotein inhibition, and antitumor activity, and which inhibit paclitaxel sensitive and resistant tumor cells. Also provided are methods of utilizing these compounds for treating tumor cells and inhibiting mitosis of cancerous cells.

  本发明提供了三环化合物，其药物可接受的盐，前药，溶剂化合物或其水合物，具有抗有丝分裂活性，抗多药耐药活性，例如P-糖蛋白抑制，以及抗肿瘤活性，且能够抑制紫杉醇敏感和耐药的肿瘤细胞。还提供了利用这些化合物治疗肿瘤细胞和抑制癌细胞有丝分裂的方法。