吲哚瑞酯 | 73758-06-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 吲哚瑞酯
• 英文名称: Indorenate
• 英文别名: methyl 3-amino-2-(5-methoxy-3-indolyl)propionate；Methyl 3-amino-2-(5-methoxyindol-3-yl) propionate；methyl 3-amino-2-(5-methoxy-1H-indol-3-yl)propanoate
• CAS: 73758-06-2
• 化学式: C₁₃H₁₆N₂O₃
• 分子量: 248.282
• InChiKey: YFEDJMLMWJSRJJ-UHFFFAOYSA-N

物化性质

• 沸点：
  442.8±45.0 °C(Predicted)
• 密度：
  1.243±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  77.3
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  吲哚瑞酯 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 2-(5-甲氧基-3-吲哚基)-3-氨基丙醇
  参考文献：
  名称：

  Tryptophan analogs. 1. Synthesis and antihypertensive activity of positional isomers

  摘要：

  A series of tryptophan analogues having the carboxyl function at the beta-position was synthesized and tested for antihypertensive activity. The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue. The methyl ester was found to be a critical structural feature for activity.

  DOI：

  10.1021/jm00348a022
• 作为产物：
  描述：

  ethyl 2-cyano-2-(1-carboethoxy-5-methoxy-3-indolyl)acetate 在 Raney Ni (W-4) sodium hydroxide 、 氯化亚砜 、 氢气 作用下， 25.0 ℃ 、344.73 kPa 条件下， 反应 26.0h， 生成 吲哚瑞酯
  参考文献：
  名称：

  Tryptophan analogs. 1. Synthesis and antihypertensive activity of positional isomers

  摘要：

  A series of tryptophan analogues having the carboxyl function at the beta-position was synthesized and tested for antihypertensive activity. The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue. The methyl ester was found to be a critical structural feature for activity.

  DOI：

  10.1021/jm00348a022

文献信息

• Tetrahydro .beta.-carbolines having anti-hypertensive activity
  申请人：Miles Laboratories, Inc.

  公开号：US04291039A1

  公开（公告）日：1981-09-22

  Disclosed are novel tetrahydro .beta.-carbolines of the formula: ##STR1## wherein R is H, OCH.sub.3 or F; R.sub.1 is H or CH.sub.3 and R.sub.2 is H or COOR.sub.3 where R.sub.3 is H or CH.sub.3. These compounds are useful as antihypertensive agents.

  揭示了一种新型的四氢β-咔啉化合物，其化学式为：##STR1## 其中R为H、OCH.sub.3或F；R₁为H或CH.sub.3，R₂为H或COOR₃，其中R₃为H或CH.sub.3。这些化合物可用作降压药物。
• [EN] NOVEL HDAC6 INHIBITORS AND THEIR USES<br/>[FR] NOUVEAUX INHIBITEURS DE HDAC6 ET LEURS UTILISATIONS
  申请人：UNIVERSITÄT REGENSBURG

  公开号：WO2016020369A1

  公开（公告）日：2016-02-11

  The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H − L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).

  本发明涉及小分子化合物及其作为HDAC抑制剂的用途以及在治疗各种疾病（如癌症）中的应用。本发明还涉及合成这些化合物的方法和治疗方法。H - L（HA），其中H是从（头基团1）、（头基团2）、（头基团3）、（头基团4）、（头基团5）和（头基团6）中选择的头基团。
• MORALES, M. S.;JOSEPH-NATHAN, RIOS Y P., REV. SOC. QUIM. MEX., 33,(1989) N, C. 331-341
  作者：MORALES, M. S.、JOSEPH-NATHAN, RIOS Y P.

  DOI：——

  日期：——
• SCHUT, R. N.;SAFDY, M. E.;HONG, E.
  作者：SCHUT, R. N.、SAFDY, M. E.、HONG, E.

  DOI：——

  日期：——
• Methods of Suppressing Appetite by the Administration of Antagonists of the Serotonin HTR1a or HTR2b Receptors or Inhibitors of TPH2
  申请人：Karsenty Gerard

  公开号：US20120115778A1

  公开（公告）日：2012-05-10

  Methods for treating eating disorders associated with excessive weight gain, suppressing appetite, reducing body weight, or treating obesity in an animal by administering one or more antagonists of the serotonin Htr1a or Htr2b receptor, or a Tph2 inhibitor are provided, or combinations thereof.