2-(5-甲氧基-3-吲哚基)-3-氨基丙醇 | 81630-85-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 2-(5-甲氧基-3-吲哚基)-3-氨基丙醇
• 中文别名: 17-(环丙基甲基)-3,14-二羟基吗啡烷-6-酮甲磺酸酯(salt)
• 英文名称: 3-amino-2-(5-methoxy-3-indolyl)-1-propanol
• 英文别名: 2-(5-Methoxy-3-indolyl)-3-aminopropanol；3-amino-2-(5-methoxy-1H-indol-3-yl)propan-1-ol
• CAS: 81630-85-5
• 化学式: C₁₂H₁₆N₂O₂
• 分子量: 220.271
• InChiKey: PUDLMPAPHGYQFC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  71.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吲哚瑞酯 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 2-(5-甲氧基-3-吲哚基)-3-氨基丙醇
  参考文献：
  名称：

  Tryptophan analogs. 1. Synthesis and antihypertensive activity of positional isomers

  摘要：

  A series of tryptophan analogues having the carboxyl function at the beta-position was synthesized and tested for antihypertensive activity. The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue. The methyl ester was found to be a critical structural feature for activity.

  DOI：

  10.1021/jm00348a022

文献信息

• Tryptophan analogs. 1. Synthesis and antihypertensive activity of positional isomers
  作者：Max E. Safdy、Elva Kurchacova、Robert N. Schut、Horacio Vidrio、Enrique Hong

  DOI：10.1021/jm00348a022

  日期：1982.6

  A series of tryptophan analogues having the carboxyl function at the beta-position was synthesized and tested for antihypertensive activity. The 5-methoxy analogue 46 exhibited antihypertensive activity in the rat via the oral route and was much more potent than the normal tryptophan analogue. The methyl ester was found to be a critical structural feature for activity.