喹啉,4-氯-3-乙基-2-甲基- | 1888-02-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 喹啉,4-氯-3-乙基-2-甲基-
• 英文名称: 4-chloro-3-ethyl-2-methylquinoline
• CAS: 1888-02-4
• 化学式: C₁₂H₁₂ClN
• mdl: MFCD01143109
• 分子量: 205.687
• InChiKey: MYOOCUSHJBZEBU-UHFFFAOYSA-N

物化性质

• 熔点：
  34-36 °C
• 沸点：
  294.8±35.0 °C(Predicted)
• 密度：
  1.156±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  喹啉,4-氯-3-乙基-2-甲基- 以17%的产率得到(3-ethyl-2-methylquinolin-4-yl)-[4-(4-methylpiperazin-1-yl)phenyl]amine
  参考文献：
  名称：

  Derivatives of quinoline as alpha-2 antagonists

  摘要：

  一种具有式I的化合物，其中A、Ra、Rb、R1至R5、m和t的定义如所披露的那样，或其药用盐或酯，可用作α-2拮抗剂。化合物I可用于治疗需要α-2拮抗剂有效的疾病或情况。

  公开号：

  US20010046991A1
• 作为产物：
  描述：

  2-乙基乙酰乙酸乙酯 在 氯化亚砜 、 对甲苯磺酸 作用下， 以 二苯醚 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 2.0h， 生成 喹啉,4-氯-3-乙基-2-甲基-
  参考文献：
  名称：

  Structure−Activity Relationship of Quinoline Derivatives as Potent and Selective α_2C-Adrenoceptor Antagonists

  摘要：

  Starting from two acridine compounds identified in a high-throughput screening campaign (1 and 2, Table 1), a series of 4-aminoquinolines was synthesized and tested for their properties on the human alpha(2)-adrenoceptor subtypes (alpha(2A), alpha(2B), and alpha(2C.)). A number of compounds with good antagonist potencies against the alpha(2C)-adrenoceptor and excellent subtype selectivities over the other two subtypes were discovered. For example, (R)-{4-[4-(3,4-dimethylpiperazin-1-yl) phenylamino] quinolin- 3- yl} methanol 6j had an antagonist potency of 8.5 nM against, and a subtype selectivity of more than 200-fold for, the alpha(2C)-adrenoceptor. Investigation of the structure-activity relationship identified a number of structural features, the most critical of which was an absolute need for a substituent in the 3-position of the quinoline ring. The 3-position on the piperazine ring was also found to play an appreciable role, as substitutions in that position exerted a significant and stereospecific beneficial effect on the alpha(2C)-adrenoceptor affinity and potency. Replacing the piperazine ring proved difficult, with 1,4-diazepanes representing the only viable alternative.

  DOI：

  10.1021/jm060262x

文献信息

• DERIVATIVES OF QUINOLINE AS ALPHA-2 ANTAGONISTS
  申请人：ORION CORPORATION FARMOS

  公开号：EP1263733A2

  公开（公告）日：2002-12-11
• US6593324B2
  申请人：——

  公开号：US6593324B2

  公开（公告）日：2003-07-15
• [EN] DERIVATIVES OF QUINOLINE AS ALPHA-2 ANTAGONISTS<br/>[FR] DERIVES DE QUINOLINE UTILISES COMME ANTAGONISTES ALPHA2
  申请人：ORION CORP

  公开号：WO2001064645A2

  公开（公告）日：2001-09-07

  The invention provides a compound of formula (I), wherein A, Ra, Rb, R1 to R5, m and t are as defined as disclosed, or a pharmaceutically acceptable salt or ester thereof, useful as alpha-2 antagonist. The compounds I can be used for the treatment of diseases or conditions wherein alpha-2 antagonists are indicated to be effective.