(E)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(3-hydroxyphenyl)-2-propen-1-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(3-hydroxyphenyl)-2-propen-1-one
• 英文别名: 3,6'-dihydroxy-2',3',4'-trimethoxychalcone；(E)-3-(3-hydroxyphenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one
• 化学式: C₁₈H₁₈O₆
• 分子量: 330.337
• InChiKey: WDNGYLYVMKTDCS-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  85.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (E)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(3-hydroxyphenyl)-2-propen-1-one 在 碘 作用下， 以 二甲基亚砜 为溶剂， 反应 2.0h， 以98%的产率得到3'-hydroxy-5,6,7-trimethoxyflavone
  参考文献：
  名称：

  Synthesis and Anticancer Activities of 5,6,7-Trimethylbaicalein Derivatives

  摘要：

  本研究旨在基于自然界中存在的黄芩素，一种来自黄芩根的黄酮类化合物，开发潜在的抗癌药物。通过将肉桂酸衍生物转化为相应的氯化物，然后在BF3·Et2O存在下与3,4,5-三甲氧基苯酚缩合，得到查尔酮。这些中间体在DMSO/I2的作用下发生分子内环化，得到所需的三甲氧基黄芩素衍生物。通过MTT比色法测定经测试化合物处理2天后的细胞活力。结果表明，大多数衍生物显示出对Hep G2细胞增殖抑制作用的提升。化合物9的抑制作用最强，其在25 μM浓度下细胞活力降至<2%。对于Hep 3B细胞，8a、8b和8f表现出中等程度的增殖抑制作用，需要25 μM浓度才能将活力降低至约30%。另一方面，前列腺DU145细胞的耐药性更强。大多数衍生物仅在100 μM或更高浓度下才导致DU145细胞60%的抑制率。

  DOI：

  10.1248/cpb.52.1162
• 作为产物：
  描述：

  间羟基肉桂酸 在 草酰氯 、 三氟化硼乙醚 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 反应 2.5h， 生成 (E)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(3-hydroxyphenyl)-2-propen-1-one
  参考文献：
  名称：

  Synthesis and Anticancer Activities of 5,6,7-Trimethylbaicalein Derivatives

  摘要：

  本研究旨在基于自然界中存在的黄芩素，一种来自黄芩根的黄酮类化合物，开发潜在的抗癌药物。通过将肉桂酸衍生物转化为相应的氯化物，然后在BF3·Et2O存在下与3,4,5-三甲氧基苯酚缩合，得到查尔酮。这些中间体在DMSO/I2的作用下发生分子内环化，得到所需的三甲氧基黄芩素衍生物。通过MTT比色法测定经测试化合物处理2天后的细胞活力。结果表明，大多数衍生物显示出对Hep G2细胞增殖抑制作用的提升。化合物9的抑制作用最强，其在25 μM浓度下细胞活力降至<2%。对于Hep 3B细胞，8a、8b和8f表现出中等程度的增殖抑制作用，需要25 μM浓度才能将活力降低至约30%。另一方面，前列腺DU145细胞的耐药性更强。大多数衍生物仅在100 μM或更高浓度下才导致DU145细胞60%的抑制率。

  DOI：

  10.1248/cpb.52.1162

文献信息

• Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease
  作者：Zhipei Sang、Xiaoming Qiang、Yan Li、Wen Yuan、Qiang Liu、Yikun Shi、Wei Ang、Youfu Luo、Zhenghuai Tan、Yong Deng

  DOI：10.1016/j.ejmech.2015.02.063

  日期：2015.4

  A series of scutellarein-O-alkylamine derivatives were designed, synthesized and tested as multifunctional agents for the treatment of Alzheimer's disease (AD). The results showed that most of these compounds exhibited good multifunctional activities. Among them, compound 16d demonstrated significant metal chelating properties, moderate acetylcholinesterase (AChE) inhibitory and anti-oxidative activity, and excellent inhibitory effects on self-induced A beta(1-42) aggregation, Cu2+-induced A beta(1-42) aggregation, human AChE-induced A beta(1-40) aggregation and disassembled Cu2+-induced aggregation of the well-structured A beta(1-42) fibrils. Both kinetic analysis of AChE inhibition and molecular modeling study suggested that 16d binds simultaneously to the catalytic active site and peripheral anionic site of AChE. Moreover, compound 16d showed a good protective effect against H2O2-induced PC12 cell injury, with low toxicity in SH-SY5Y cells. Furthermore, the step-down passive avoidance test showed this compound significantly reversed scopolamine-induced memory deficit in mice. Thus, 16d was shown to be an interesting multifunctional lead compound worthy of further study. (C) 2015 Elsevier Masson SAS. All rights reserved.
• Multifunctional scutellarin–rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer’s disease
  作者：Zhipei Sang、Yan Li、Xiaoming Qiang、Ganyuan Xiao、Qiang Liu、Zhenghuai Tan、Yong Deng

  DOI：10.1016/j.bmc.2015.01.005

  日期：2015.2

  To discover multifunctional agents for the treatment of Alzheimer's disease (AD), a series of scutellarein carbamate derivatives were designed and synthesized based on the multitarget-directed ligand strategy. Their acetylcholinesterase and butyrylcholinesterase inhibitory activities, antioxidant activities, metal-chelating properties and neuroprotective effects against hydrogen peroxide induced PC12 cell injury were evaluated in vitro. The results showed that most of the synthetic compounds exhibited good multifunctional activities. In particular, compound 15c exhibited dual inhibitory potency on acetylcholinesterase and butyrylcholinesterase with IC50 values of 0.57 and 22.6 mu M, respectively, and good antioxidative activity, with a value 1.3-fold of Trolox. In addition, 15c acted as a selective biometal chelator and possessed neuroprotective effects. Furthermore, 15c could cross the blood-brain barrier (BBB) in vitro and had significant neuroprotective effects in scopolamine-induced cognitive impairment in mice. Taken together, these results suggest that compound 15c might be a potential multifunctional agent for the treatment of AD. (c) 2015 Elsevier Ltd. All rights reserved.