± 1 nM, respectively. Compounds 2 and 7 showed only modest A2780 activities, with IC50 values of 2.1 ± 0.3 and 4.9 ± 0.1 μM, respectively, while compounds 3 and 6 had IC50 values of >10 μM. Compound 1 also had potent antiproliferative activity against the HCT-116 human colon carcinoma cell line, with an IC50 value of 20.5 nM, and compound 4 exhibited modest antiproliferative activity against the A2058
这两个新的
木脂素3α- ø - (β- d
吡喃
葡萄糖基)desoxypodophyllotoxin(1)和4- ø - (β- d
吡喃
葡萄糖基)dehydropodophyllotoxin(2)从分离闭花木属boivinianus,与已知的木
酚素deoxypicropodophyllotoxin一起(3) ,(±)-β-apopicropodophyllin(4),( - ) - desoxypodophyllotoxin(5),( - ) -
亚太因(6),和β-peltatin -5- ö -β- d
吡喃
葡萄糖苷(7)。所有化合物的结构均通过光谱技术表征。化合物1,图4和5显示了对A2780卵巢癌
细胞系的有效抗增殖活性,IC 50值分别为33.0±3.6、63.1±6.7和230±1 nM。化合物2和7仅显示适度的A2780活性,IC 50值分别为2.1±0.3和4.9±0.1μM,而化合物3和6的IC