4-ethyl-2-hexyl-2-methyl-1,3-dioxolane

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-ethyl-2-hexyl-2-methyl-1,3-dioxolane
• 化学式: C₁₂H₂₄O₂
• 分子量: 200.321
• InChiKey: OMNMFXDKFCPMPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-辛炔 、 1,2-丁二醇 在 [Ir(1,5-cyclooctadiene)2]PF6 三异丙基亚磷酸酯 、 氯化锆(IV) 作用下， 以 1,4-二氧六环 为溶剂， 反应 15.0h， 以86%的产率得到4-ethyl-2-hexyl-2-methyl-1,3-dioxolane
  参考文献：
  名称：

  Iridium complex-catalyzed addition of water and alcohols to non-activated terminal alkynes

  摘要：

  The addition of water and alcohols to non-activated terminal alkynes was found to be promoted by an iridium complex combined with Lewis acid and phosphite. Thus, terminal alkynes reacted with water or alcohols to give ketones or ketals, respectively, in good to excellent yields. alpha,omega-Diyne like 1,7-octadiyne, was converted into 1-(2-methyl-cyclopent-1-enyl)ethanone through the intramoleculer aldol condensation of the resulting 2,7-octanedione induced by Lewis acid. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.12.010

文献信息

• Iridium complex-catalyzed addition of water and alcohols to non-activated terminal alkynes
  作者：Tomotaka Hirabayashi、Yoshio Okimoto、Akiyo Saito、Masao Morita、Satoshi Sakaguchi、Yasutaka Ishii

  DOI：10.1016/j.tet.2005.12.010

  日期：2006.3

  The addition of water and alcohols to non-activated terminal alkynes was found to be promoted by an iridium complex combined with Lewis acid and phosphite. Thus, terminal alkynes reacted with water or alcohols to give ketones or ketals, respectively, in good to excellent yields. alpha,omega-Diyne like 1,7-octadiyne, was converted into 1-(2-methyl-cyclopent-1-enyl)ethanone through the intramoleculer aldol condensation of the resulting 2,7-octanedione induced by Lewis acid. (c) 2005 Elsevier Ltd. All rights reserved.