1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-4-phenyl-1H-1,2,3-triazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-4-phenyl-1H-1,2,3-triazole
• 英文别名: 1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-Heptadecafluorodecyl)-4-phenyltriazole
• 化学式: C₁₈H₁₀F₁₇N₃
• 分子量: 591.27
• InChiKey: UFTADGQSXVJEEV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  19

反应信息

• 作为产物：
  描述：

  1,1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-十七氟-10-碘庚烷 在 copper(l) iodide 、 sodium azide 、 二异丙胺 作用下， 以 2,2,2-三氟乙醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-4-phenyl-1H-1,2,3-triazole
  参考文献：
  名称：

  Fluorous click chemistry as a practical tagging method

  摘要：

  基于催化1,3-偶极环加成反应作为关键步骤开发了高效的全氟标签标记方法。

  DOI：

  10.1039/b504973c
• 作为试剂：
  描述：

  环己酮 、 对硝基苯甲醛 在 1-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)-4-phenyl-1H-1,2,3-triazole 作用下， 以 乙醇 为溶剂， 反应 20.0h， 以95%的产率得到2,6-di(p-nitrobenzylidene)cyclohexanone
  参考文献：
  名称：

  A recyclable fluoroalkylated 1,4-disubstituted [1,2,3]-triazole organocatalyst for aldol condensation of aldehydes and ketones

  摘要：

  A new fluoroalkylated 1,4-disubstituted [1,2,3]-triazole was prepared and acted as an organocatalyst for aldol condensation of different ketones with various aldehydes. Aldol condensation proceeded efficiently in the presence of catalytic amount of fluoroalkylated [1,2,3]-triazole. The catalyst could be easily recovered by fluorous solid-phase extraction with excellent purity and reused for three runs with slightly decrease in its activity. Crown Copyright (c) 2010 Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2010.11.004

文献信息

• A recyclable fluoroalkylated 1,4-disubstituted [1,2,3]-triazole organocatalyst for aldol condensation of aldehydes and ketones
  作者：Yi-Wei Zhu、Wen-Bin Yi、Chun Cai

  DOI：10.1016/j.jfluchem.2010.11.004

  日期：2011.1

  A new fluoroalkylated 1,4-disubstituted [1,2,3]-triazole was prepared and acted as an organocatalyst for aldol condensation of different ketones with various aldehydes. Aldol condensation proceeded efficiently in the presence of catalytic amount of fluoroalkylated [1,2,3]-triazole. The catalyst could be easily recovered by fluorous solid-phase extraction with excellent purity and reused for three runs with slightly decrease in its activity. Crown Copyright (c) 2010 Published by Elsevier B.V. All rights reserved.
• Fluorous click chemistry as a practical tagging method
  作者：Zoltán Kaleta、Orsolya Egyed、Tibor Soós

  DOI：10.1039/b504973c

  日期：——

  Highly efficient fluorous tagging methodology was developed based on catalytic 1,3-dipolar cycloaddition as the key step.

  基于催化1,3-偶极环加成反应作为关键步骤开发了高效的全氟标签标记方法。