多佐胺-2-3 | 148719-91-9

• 物质功能分类: 医药中间体 - 噻吩类化合物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 多佐胺-2-3
• 中文别名: (6S)-5,6-二氢-6-甲基-4H-噻吩并[2,3-b]噻喃-4-酮7,7-二氧化物多佐胺-2-3；(6S)-5,6-二氢-6-甲基-4H-噻吩并[2,3-b]噻喃-4-酮 7,7-二氧化物；(6S)-5,6-二氢-6-甲基-4H-噻吩并(2,3-b)噻喃-4-酮-7,7-二氧化物
• 英文名称: (S)-5,6-dihydro-6-methylthieno<2,3-b>thiopyran-4-one 7,7-dioxide
• 英文别名: (6S)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-4-one-7,7-dioxide；(S)-6-Methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-one 7,7-dioxide；(6S)-6-methyl-7,7-dioxo-5,6-dihydrothieno[2,3-b]thiopyran-4-one
• CAS: 148719-91-9
• 化学式: C₈H₈O₃S₂
• 分子量: 216.282
• InChiKey: LQUUXMUPBQBKHA-YFKPBYRVSA-N

物化性质

• 沸点：
  441.9±45.0 °C(Predicted)
• 密度：
  1.453

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  87.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  多佐胺-2-3 在 sodium tetrahydroborate 作用下， 以 甲醇 、 二氯甲烷 、 水 、 甲苯 为溶剂， 以84%的产率得到多佐胺-2-4
  参考文献：
  名称：

  Process for obtaining 4-hydroxy-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-7,7-dioxide and its enantiomers, and applications thereof

  摘要：

  该发明涉及一种通过用产生氢化物离子的还原剂还原5,6-二氢-6-甲基-4H-噻吩[2,3-b]噻吩吡喃-4-酮-7,7-二氧化物，从而获得顺式-4-羟基-6-甲基-5,6-二氢-4H-噻吩[2,3-b]噻吩吡喃-7,7-二氧化物，其对映体或其混合物的过程。所得化合物在手性活性成分合成中作为中间体有用。

  公开号：

  EP2128161A1
• 作为产物：
  描述：

  多佐胺-2-2 在 sodium tungstate (VI) dihydrate 、 双氧水 作用下， 以 乙酸乙酯 、 甲苯 为溶剂， 以80%的产率得到多佐胺-2-3
  参考文献：
  名称：

  Process for obtaining 4-hydroxy-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-7,7-dioxide and its enantiomers, and applications thereof

  摘要：

  该发明涉及一种通过用产生氢化物离子的还原剂还原5,6-二氢-6-甲基-4H-噻吩[2,3-b]噻吩吡喃-4-酮-7,7-二氧化物，从而获得顺式-4-羟基-6-甲基-5,6-二氢-4H-噻吩[2,3-b]噻吩吡喃-7,7-二氧化物，其对映体或其混合物的过程。所得化合物在手性活性成分合成中作为中间体有用。

  公开号：

  EP2128161A1

文献信息

• Process for Preparing Enantiomerically Enriched Oxamides
  申请人：Zach System S.P.A.

  公开号：US20150191485A1

  公开（公告）日：2015-07-09

  The present invention relates to a chiral oxamide of formula (I) useful as an intermediate in the preparation of dorzolamide, and to the preparation thereof. The invention also relates to the preparation of dorzolamide, to the hydrochloride salt thereof, and to the active ingredient contained in a drug useful in the treatment of glaucoma, by means of the intermediate of formula (I).

  本发明涉及一种手性酰胺，其化学式为（I），可用作多索胺制备中间体，并涉及其制备方法。该发明还涉及多索胺的制备，其盐酸盐，以及通过化学式（I）的中间体制备用于治疗青光眼的药物中所含的活性成分。
• [EN] ASYMMETRIC REDUCTION PROCESS<br/>[FR] PROCÉDÉ DE RÉDUCTION ASYMÉTRIQUE
  申请人：ZACH SYSTEM SPA

  公开号：WO2012120086A1

  公开（公告）日：2012-09-13

  The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO2 and R4 is hydrogen or an SO2NH2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.

  本发明涉及一种立体选择性还原程序，通过氢转移的催化不对称加氢，得到一种化合物，其化学式为（I），其中X为S或SO2，R4为氢或SO2NH2基团，从相应的酮前体中获得。所述化合物的化学式（I）可作为多索胺或其盐的盐酸盐的制备中间体。
• Process for preparing thienothiopyran derivative
  申请人：Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

  公开号：US05565345A1

  公开（公告）日：1996-10-15

  A process for preparing 5,6-dihydro-4-hydroxy-(S)-6-methyl-thieno[2,3-b]thiopyran-7,7-dioxide having the formula (II): ##STR1## which comprises subjecting 5,6-dihydro-4-oxo-(S)-6-methyl-thieno[2,3-b]thiopyran-7,7-dioxide having the formula (I): ##STR2## to the action of a microorganism to reduce the thienothiopyran derivative having the formula (I), and collecting 5,6-dihydro-4-hydroxy-(S)-6-methyl-thieno-[2,3-b]thiopyran-7,7-dioxide having the formula (II) from the reaction mixture, wherein said microorganism belongs to the genus selected from the group consisting of Ambrosiozyma, Arthroascus, Ashbya, Candida, Cryptococcus, Hansenula, Kluyveromyces, Lipomyces, Lodderomyces, Metschnikowia, Pachysolen, Pichia, Rhodosporidium, Rhodotorula, Saccharomyces, Saccharomycopsis, Schwanniomyces, Sporidiobolus, Spolobolomyces, Stephanoascus, Trigonopsis, Trichosporon and Wingea, according to which, a simple and effective. process for preparing 5,6-dihydro-4-hydroxy-(S)-6-methyl-thieno-[2,3-b]thiopyran-7,7-dioxide.

  一种制备式（II）的5,6-二氢-4-羟基-(S)-6-甲基噻吩[2,3-b]噻吩吡喃-7,7-二氧化物的工艺，包括将式（I）的5,6-二氢-4-氧代-(S)-6-甲基噻吩[2,3-b]噻吩吡喃-7,7-二氧化物暴露于微生物作用下以还原式（I）的噻吩噻吩吡喃衍生物，并从反应混合物中收集式（II）的5,6-二氢-4-羟基-(S)-6-甲基噻吩[2,3-b]噻吩吡喃-7,7-二氧化物，其中所述微生物属于以下组中所选的属：Ambrosiozyma、Arthroascus、Ashbya、Candida、Cryptococcus、Hansenula、Kluyveromyces、Lipomyces、Lodderomyces、Metschnikowia、Pachysolen、Pichia、Rhodosporidium、Rhodotorula、Saccharomyces、Saccharomycopsis、Schwanniomyces、Sporidiobolus、Spolobolomyces、Stephanoascus、Trigonopsis、Trichosporon和Wingea，因此，提供了一种简单有效的制备5,6-二氢-4-羟基-(S)-6-甲基噻吩[2,3-b]噻吩吡喃-7,7-二氧化物的工艺。
• ASYMMETRIC REDUCTION PROCESS
  申请人：Volpicelli Raffaella

  公开号：US20130338377A1

  公开（公告）日：2013-12-19

  The present invention relates to a stereoselective reduction procedure to obtain, by means of catalytic asymmetric hydrogenation by hydrogen transfer, a compound of formula (I) in which X is S or SO 2 and R 4 is hydrogen or an SO 2 NH 2 group, from the corresponding ketone precursor, said compound of formula (I) being useful as an intermediate in the preparation of dorzolamide or of the hydrochloride salt thereof.

  本发明涉及一种立体选择性还原程序，通过氢转移的催化不对称氢化反应，从相应的酮前体中得到式（I）的化合物，其中X为S或SO2，R4为氢或SO2NH2基团，所述式（I）的化合物在多索胺或其盐的制备中作为中间体有用。
• METHOD FOR SEPARATING OF OPTICALLY PURE THIOPHENE COMPOUNDS USING SIMULATED MOVING BED CHROMATOGRAPHY
  申请人：Koh Jae Suk

  公开号：US20090234140A1

  公开（公告）日：2009-09-17

  Disclosed herein is a method of producing an optically active thiophene-based compound using a simulated moving bed adsorption separation process, and more specifically, a method of continuously separating a racemic thiophene-based compound into its optically active thiophene-based compounds having high purity, through optical resolution using the simulated moving bed process. According to the method of the current invention, a racemic mixture of a thiophene-based compound can be continuously separated into its optically active thiophene-based compounds having high purity, which is an intermediate of optically active dorzolamide acting as a topical therapeutic agent for glaucoma, using a simulated moving bed adsorption separation technique, thereby increasing industrial usability.

  本发明公开了一种使用模拟移动床吸附分离工艺生产光学活性噻吩基化合物的方法，更具体地说，本发明公开了一种通过模拟移动床工艺进行光学分辨，将混合的噻吩基化合物连续分离成高纯度的光学活性噻吩基化合物的方法。根据本发明的方法，可以使用模拟移动床吸附分离技术将噻吩基化合物的混合物连续分离成高纯度的光学活性噻吩基化合物，该化合物是治疗青光眼的局部治疗剂光学活性多索胺的中间体，从而提高了其工业可用性。