(2-乙酰基-4-甲基苯基)乙酸酯 | 34087-19-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (2-乙酰基-4-甲基苯基)乙酸酯
• 英文名称: 2-acetyl-4-methylphenyl acetate
• 英文别名: 1-(2-acetoxy-5-methyl-phenyl)-ethanone；1-(2-Acetoxy-5-methyl-phenyl)-aethanon；2-Acetoxy-5-methyl-acetophenon；(2-acetyl-4-methylphenyl) acetate
• CAS: 34087-19-9
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.214
• InChiKey: KTGOJCBKYLXJIO-UHFFFAOYSA-N

物化性质

• 熔点：
  35 °C
• 沸点：
  299.4±28.0 °C(Predicted)
• 密度：
  1.099±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-乙酰基-4-甲基苯基)乙酸酯 在 水 、 氯 、 溶剂黄146 作用下， 生成 2-氯-1-(2-羟基-5-甲基苯基)乙酮
  参考文献：
  名称：

  Pendse; Limaye, Rasayanam, 1955, vol. 2, p. 74,78

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(2-乙酰氧基-5-甲基苯基)乙酸乙烯酯 生成 (2-乙酰基-4-甲基苯基)乙酸酯
  参考文献：
  名称：

  GARCIA H.; MARTINEZ-UTRILLA R.; MIRANDA M. A., TETRAHEDRON LETT., 1981, 22, NO 18, 1749-1750

  摘要：

  DOI：

文献信息

• Multicyclic bis-amide MMP inhibitors
  申请人：Powers Timothy

  公开号：US20060173183A1

  公开（公告）日：2006-08-03

  The present invention relates generally to bis-amide group containing pharmaceutical agents, and in particular, to multicyclic bis-amide MMP-13 inhibitor compounds. More particularly, the present invention provides a new class of MMP-13 inhibiting compounds, containing a pyrimidinyl bis-amide group in combination with a heterocyclic moiety, that exhibit an increased potency and solubility in relation to currently known bis-amide group containing MMP-13 inhibitors.

  本发明总体涉及含有双酰胺基团的药物制剂，特别是多环双酰胺MMP-13抑制剂化合物。更具体地，本发明提供了一类新型的MMP-13抑制化合物，它们含有与杂环部分结合的嘧啶基双酰胺基团，与目前已知含双酰胺基团的MMP-13抑制剂相比，显示出增加的活性和溶解度。
• [EN] PEGYLATED CARFILZOMIB COMPOUNDS<br/>[FR] COMPOSÉS DE CARFILZOMIB PÉGYLÉS
  申请人：AMGEN INC

  公开号：WO2017205392A1

  公开（公告）日：2017-11-30

  The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein. The invention also provides methods of making and using these compounds to treat cancer, and particularly to treat hematological malignancies including multiple myeloma.

  本发明提供了聚合物PEG化的卡菲索米布化合物及其药用盐，其化学式为I，其中R1、R2、连接基、PEG、n和o如本文所定义。本发明还提供了制备和使用这些化合物来治疗癌症，特别是治疗包括多发性骨髓瘤在内的血液恶性肿瘤的方法。
• Radiation curable dispersions containing high molecular weight nonpolymerizable vinyl resins
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0021703A1

  公开（公告）日：1981-01-07

  There are disclosed dispersions of high molecular weight, essentially non-polymerizablevinyl resins in mixtures of radiation curable monofunctional and polyfunctional acrylyl monomers and/or oligomers. The dispersions are useful as coating and ink compositions.

  本发明公开了高分子量、基本上不可聚合的乙烯基树脂在可辐射固化的单官能团和多 官能团丙烯酸酯单体和/或低聚物混合物中的分散体。这些分散体可用作涂料和油墨组合物。
• A method of producing a foam from a radiation-curable composition
  申请人：W.R. Grace & Co.-Conn.

  公开号：EP0222680A2

  公开（公告）日：1987-05-20

  This invention relates to a process of producing a cured foamed polymer by mechanically frothing a radiation-curable composition and curing the frothed composition with radiation and using such foams in graphic art devices such as compressible printing blankets. It also relates to uses of unfoamed radiation-cured polymer in graphic art devices.

  本发明涉及一种通过对辐射固化组合物进行机械发泡和用辐射固化发泡组合物来生产固化发泡聚合物的工艺，以及在可压缩印刷毯等图形艺术装置中使用这种泡沫的工艺。本发明还涉及未发泡辐射固化聚合物在图形艺术设备中的用途。
• Multi-functional unsaturated polyester polyols
  申请人：Armstrong World Industries, Inc.

  公开号：EP1333047A1

  公开（公告）日：2003-08-06

  Novel multifunctional unsaturated polyester polyols, UV-curable top coat formulations including these polyols, and a one-step process for preparing these polyols, are disclosed. Surface coverings and surface covering components including these top coat formulations are also disclosed. The polyols are generally formed by the ring opening polymerization of a lactone with a compound of the formula (R1)aR(OH)b, where a + b > 2. R1 is a double bond-containing moiety such as allyl, vinyl, vinylidene, vinyl ether, acrylate, and the like. R is generally an alkyl, aryl, aralkyl, alkaryl, ether or ester group, including substituted versions thereof. R can be a polymer, including polymers with a plurality of functional groups. Examples of lactone groups which can be used include caprolactone, lactide and glycolide. The polyols can be used in 100% solids, solvent and water based radiation cured coatings, thermal cured coatings, dual cure (thermal with UV/e-beam, or UV/e-beam with thermal curing) coatings, and other types of coatings. These new resins enhance coating performance due to their multi-functional groups in the polymer chain.

  本发明公开了新型多功能不饱和聚酯多元醇、包括这些多元醇的紫外线固化面漆配方以及制备这些多元醇的一步法工艺。还公开了包括这些面漆配方的表面覆盖物和表面覆盖物成分。多元醇一般由内酯与式 (R1)aR(OH)b 的化合物开环聚合而成，其中 a + b > 2。R1 是含双键的分子，如烯丙基、乙烯基、亚乙烯基、乙烯基醚、丙烯酸酯等。R 通常是烷基、芳基、芳烷基、烷芳基、醚基或酯基，包括其取代型。R 可以是聚合物，包括具有多个官能团的聚合物。可使用的内酯基团包括己内酯、内酯和乙二醇内酯。多元醇可用于 100% 固含量、溶剂型和水基辐射固化涂料、热固化涂料、双固化（热固化与紫外线/电子束，或紫外线/电子束与热固化）涂料以及其他类型的涂料。由于聚合物链中含有多功能基团，这些新型树脂可提高涂料性能。