(2-甲基烯丙氧基)-乙酸甲酯 | 137840-76-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: (2-甲基烯丙氧基)-乙酸甲酯
• 英文名称: methyl [(2-methylprop-2-en-1-yl)oxy]acetate
• 英文别名: (2-Methyl-allyloxy)-acetic acid methyl ester；methyl 2-(2-methylprop-2-enoxy)acetate
• CAS: 137840-76-7
• 化学式: C₇H₁₂O₃
• mdl: MFCD09032523
• 分子量: 144.17
• InChiKey: UGTZQONBXVCMGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2-甲基烯丙氧基)-乙酸甲酯 在 potassium osmate(VI) 、 sodium periodate 、 sodium t-butanolate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 12.08h， 生成 2H-吡喃-3,5(4H,6H)-二酮
  参考文献：
  名称：

  An Improved Synthesis of Pyran-3,5-dione:  Application to the Synthesis of ABT-598, a Potassium Channel Opener, via Hantzsch Reaction

  摘要：

  Ketoester 1 is cyclized to give pyran-3,5-dione 2 in 78% yield using a parallel addition of ketoester 1 and base NaOBu in refluxing THE Compared to the previously reported procedures, these optimized conditions have significantly increased the yield of this transformation and the quality of pyran 2 and prove to be suitable for large-scale preparation. An application of 2 to the synthesis of ABT-598, a potassium channel opener, is demonstrated.

  DOI：

  10.1021/jo052226w
• 作为产物：
  描述：

  (2-甲基烯丙氧基)-乙酸 在 Amberlyst-15 resin 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以57.1 g的产率得到(2-甲基烯丙氧基)-乙酸甲酯
  参考文献：
  名称：

  [EN] HETERO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES
  [FR] HÉTÉRO-1,5,6,7-TÉTRAHYDRO-4H-INDOL-4-ONES

  摘要：

  本文件所述的式(I)化合物、其制备方法以及作为药物的用途。

  公开号：

  WO2017102649A1

文献信息

• Activated ester monomers, polymers formed therefrom and coating compositions containing said polymers
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0020000A1

  公开（公告）日：1980-12-10

  Ethylenically unsaturated monomers containing activated ester groups are used to make polymers and copolymers which are useful in coatings, adhesives and moldings. The monomers have the formula: wherein A is an organic group containing a polymerizable vinyl linkage; Z is selected from O or S; m and n are integers each selected from 0 and 1. Y is a bridging unit, X is selected from the group consisting essentially of wherein R' is an alkyl group with 1-8 carbon atoms: and R is an aliphatic moiety.

  含有活化酯基的乙烯基不饱和单体可用于制造聚合物和共聚物，这些聚合物和共聚物可用于涂料、粘合剂和模塑。这些单体的化学式如下 其中 A 是含有可聚合乙烯基连接的有机基团；Z 选自 O 或 S；m 和 n 分别是选自 0 和 1 的整数；Y 是桥接单元、 X 主要选自以下组成的组 其中 R' 是含有 1-8 个碳原子的烷基：R 是脂肪族分子。
• Copolymers formed from activated ester monomers, and coating compositions containing said copolymers
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0049910A2

  公开（公告）日：1982-04-21

  There are provided copolymers of (I) a compound of the - formula: wherein A is an organic group containing a polymerizable vinyl linkage; Z is selected from O or S; m and n are integers each selected from 0 and 1, Y is a bridging unit; X is selected from the group consisting essentially of wherein R' is an alkyl group with 1-8 carbon atoms, and R is an aliphatic moiety; and (II) one or more copolymerizable vinyl monomers. The copolymers may be incorporated into curable coating compositions with compounds containing at least two primary or secondary amine groups per molecule.

  提供了(I)式化合物的共聚物： 其中 A 是含有可聚合乙烯基连接的有机基团；Z 选自 O 或 S；m 和 n 分别是选自 0 和 1 的整数；Y 是桥接单元；X 选自基本上由以下各项组成的组 其中 R' 是含有 1-8 个碳原子的烷基，R 是脂肪族分子；以及 (II) 一种或多种可共聚的乙烯基单体。共聚物可与每个分子至少含有两个伯胺或仲胺基团的化合物一起掺入可固化的涂料组合物中。
• Copolymer binders
  申请人：GENCORP INC.

  公开号：EP0470689A1

  公开（公告）日：1992-02-12

  A latex useful as a binder for paper, nonwovens, or textiles is prepared by copolymerising in aqueous emulsion using a redox initiator at low temperature, e.g. 5°C, a mixture of 35 to 60% weight of a conjugated diene monomer and from about 30 to 65% by weight of a vinyl aryl monomer. Additional improvements can be obtained by incorporating in the mixture a small percentage by weight of copolymerisable monomers such as acrylic acid, methacrylic acid, itaconic acid and/or a functional type monomer having an activatable methyl, ethyl, propyl or butyl ester group and a vinyl group.

  一种可用作纸张、无纺布或纺织品粘合剂的胶乳是通过在低温（如 5℃）下使用氧化还原引发剂在水性乳液中共聚35-60%（按重量计）的共轭二烯单体和30-65%（按重量计）的乙烯基芳基单体的混合物来制备的。在混合物中加入少量可共聚的单体，如丙烯酸、甲基丙烯酸、衣康酸和/或具有可活化的甲基、乙基、丙基或丁基酯基和乙烯基的官能团型单体，可获得进一步的改进。
• [2,3]-Wittig rearrangement of allylic glycolate esters via boron and tin enolates
  作者：Taeboem Oh、Zbigniew Wrobel、Steven M. Rubenstein

  DOI：10.1016/s0040-4039(00)92271-8

  日期：1991.1

  Wittig rearrangement of allylic glycolate esters via boron and tin enolates gave diastereoselectivities as high as 99.5 : 0.5. Tin enolates were more stereoselective than boron enolates.
• HETERO-1,5,6,7-TETRAHYDRO-4H-INDOL-4-ONES
  申请人：BAYER PHARMA AKTIENGESELLSCHAFT

  公开号：US20200216439A1

  公开（公告）日：2020-07-09

  Compounds of formula (I) as described herein, processes for their production and their use as pharmaceuticals.