(2E)-3-(2,5-二羟基苯基)丙烯酸 | 38489-67-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 中文名称: (2E)-3-(2,5-二羟基苯基)丙烯酸
• 英文名称: 2,5-dihydroxycinnamate
• 英文别名: (E)-2,5-dihydroxy cinnamic acid；(E)-2,5-dihydroxycinnamic acid；2,5-dihydroxycinnamic acid；2,5-dihydroxy-trans-cinnamic acid；2,5-Dihydroxy-trans-zimtsaeure；(E)-3-(2,5-dihydroxyphenyl)-2-propenoic acid；(E)-3-(2,5-dihydroxyphenyl)prop-2-enoic acid
• CAS: 38489-67-7
• 化学式: C₉H₈O₄
• 分子量: 180.16
• InChiKey: JXIPYOZBOMUUCA-DAFODLJHSA-N

物化性质

• 沸点：
  457.8±35.0 °C(Predicted)
• 密度：
  1.478±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2E)-3-(2,5-二羟基苯基)丙烯酸 在 乙酸乙酯 、 铂 作用下， 200.0~220.0 ℃ 、1.33 Pa 条件下， 生成 1,4-二羟基-2-乙基苯
  参考文献：
  名称：

  Electron Exchange-Polymers. II. Vinylhydroquinone Monomer and Polymer

  摘要：

  DOI：

  10.1021/ja01170a010
• 作为产物：
  描述：

  2,5-二羟基苯甲醛 、 乙氧甲酰基甲基三苯基溴化膦 在 sodium hydroxide 、 potassium carbonate 作用下， 生成 (2E)-3-(2,5-二羟基苯基)丙烯酸
  参考文献：
  名称：

  Dupin, J. F. E.; Chenault, J., Synthetic Communications, 1985, vol. 15, # 7, p. 581 - 586

  摘要：

  DOI：

文献信息

• Improvement in the total synthesis of Erbstatin analogs
  申请人：FARMITALIA CARLO ERBA S.r.l.

  公开号：EP0440887A1

  公开（公告）日：1991-08-14

  The present invention relates to a new process for the preparation of Erbstatin and Erbstatin analogs, which can be represented by the following formula (I) wherein R is hydrogen, a lower alkyl or a lower alkanoyl group; n is an integer of 1 to 3; A is -CH=CH- or -CH₂-CH₂-; R₁ is hydrogen or a lower alkyl group, and R₂ is a hydrogen or halogen atom,

  本发明涉及一种制备厄布司他汀和厄布司他汀类似物的新工艺，其可由下式（I）表示 其中 R 是氢、低级烷基或低级烷酰基； n 是 1 至 3 的整数； A 是-CH=CH-或-CH₂-CH₂-； R₁ 是氢或低级烷基，以及 R₂ 是氢原子或卤素原子、
• Enhanced production of taxanes by cell cultures of taxus species
  申请人：Phyton Inc.

  公开号：EP1398384A1

  公开（公告）日：2004-03-17

  This invention provides methods whereby taxol, baccatin III, and other taxol-like compounds, or taxanes, can be produced in very high yield from all known Taxus species, e.g. brevifolia, canadensis, cuspidata, baccata, globosa, floridana, wallichiana, media and chinensis. Particular modifications of culture conditions (i.e. media composition and operating modes) have been discovered to enhance the yield of various taxanes from cell culture of all species of Taxus. Particularly preferred enhancement agents include silver ion or complex, jasmonic acid (especially the methyl ester), auxin-related growth regulators, and inhibitors of the phenylpropanoid pathway, such as 3,4-methylenedioxy-6-nitrocinnamic acid. These enhancement agents may be used alone or in combination with one another or other yield-enhancing conditions. While the yield of taxanes from plant cell culture of T. chinensis is particularly enhanced by use of one or more of these conditions, yield of taxanes for all Taxus species has been found to benefit from use of these conditions.

  本发明提供了可从所有已知的紫杉品种（如brevifolia、canadensis、cuspidata、baccata、globosa、floridana、wallichiana、media和chinensis）中以极高产率生产紫杉醇、巴卡丁Ⅲ和其他紫杉醇类化合物或紫杉素的方法。已发现对培养条件（即培养基成分和操作模式）的特定修改可提高所有紫杉属植物细胞培养中各种紫杉素的产量。特别优选的增强剂包括银离子或银离子络合物、茉莉酸（尤其是甲酯）、与辅助素相关的生长调节剂和苯丙醇途径抑制剂，如 3,4-亚甲二氧基-6-硝基肉桂酸。这些增产剂可以单独使用，也可以相互结合或在其他增产条件下使用。虽然使用其中一种或多种条件可特别提高植物细胞培养 T. chinensis 的紫杉醇产量，但已发现使用这些条件可提高所有紫杉属植物的紫杉醇产量。
• TRANSGENIC TOMATO PLANTS WITH ACQUIRED RESISTANCE TO PSEUDOMONAS SYRINGAE PV. TOMATO
  申请人：Consejo Superior de Investigaciones Cientificas

  公开号：EP1808486A1

  公开（公告）日：2007-07-18

  The bacterial spot caused by pathogen Pseudomonas syringae pv. tomato (P. s. tomato) is a devastating disease affecting tomato plants. The invention shows that the mere inhibition of the expression of gene Ep5C , coding an extracellular cationic peroxidase is sufficient to impart marked resistance to P. s. tomato . Said inhibition found in tomato plants provides a resistance with no need for activation of defence pathways currently described and controlled by salicylic acid and jasmonic acid. In addition the invention shows that Ep5C is repressed at the transcription level in healthy plants through the formation of a stable complex including proteins and one cis acting element identified within the 5' region of the gene promoter. Said complex is disabled in tissue infected with P. s. tomato and shows maximum expression in the gene. Thus Ep5C gene as well as its promoter provides a new genetic asset to develop plants resisting to be bacterial spot disease.

  由病原体 P. syringae pv. tomato（P. s. tomato）引起的细菌性斑点病是一种影响番茄植株的毁灭性病害。本发明表明，仅仅抑制编码细胞外阳离子过氧化物酶的基因 Ep5C 的表达，就足以使番茄对 P. s. tomato 产生明显的抗性。在番茄植株中发现的这种抑制提供了一种抗性，而无需激活目前描述的由水杨酸和茉莉酸控制的防御途径。此外，本发明还表明，在健康植物中，Ep5C 通过形成稳定的复合物（包括蛋白质和在基因启动子 5' 区域内确定的一个顺式作用元件）而在转录水平上受到抑制。该复合物在感染番茄黑斑病菌的组织中失效，并显示出最大的基因表达量。因此，Ep5C 基因及其启动子为培育抗细菌性斑点病的植物提供了一种新的遗传资产。
• Moisture-proof material
  申请人：NITTO DENKO CORPORATION

  公开号：EP2565245A2

  公开（公告）日：2013-03-06

  The present invention relates to a moisture-proof material having a polyurethane film substrate and an adhesive layer formed on at least one surface of the substrate, which material shows a tensile strength of not less than 7500psi, and an elongation at break of not less than 550%.

  本发明涉及一种防潮材料，它具有聚氨酯薄膜基材和形成于基材至少一个表面的粘合剂层，该材料的拉伸强度不小于 7500psi，断裂伸长率不小于 550%。
• 2,5-dihydroxybenzene compounds for the treatment of of cancer of an organ
  申请人：Action Medicines, S.L.

  公开号：EP2620145A2

  公开（公告）日：2013-07-31

  The present invention refers to the use of a compound of Formula (I") or pharmaceutically acceptable salt or solvate, isomer or prodrug thereof in the manufacturing of a medicament for the treatment and/or prophylaxis of cancer of an organ.

  本发明是指在制造治疗和/或预防器官癌症的药物中使用式（I"）化合物或其药学上可接受的盐或溶解物、异构体或原药。