(2E,4E,6E,8E)-N-乙氧基-3,7-二甲基-9-(2,6,6-三甲基-1-环己烯基)壬-2,4,6,8-四烯-1-亚胺 | 99794-88-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: (2E,4E,6E,8E)-N-乙氧基-3,7-二甲基-9-(2,6,6-三甲基-1-环己烯基)壬-2,4,6,8-四烯-1-亚胺
• 英文名称: Retinal-O-ethyloxime
• 英文别名: (E,2E,4E,6E,8E)-N-ethoxy-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-imine
• CAS: 99794-88-4
• 化学式: C₂₂H₃₃NO
• 分子量: 327.5
• InChiKey: HIMHNTFVMDPYEF-DQCGJCGASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• THERAPEUTIC REGIMEN AND METHOD FOR TREATING OR AMELIORATING VISUAL DISORDERS ASSOCIATED WITH AN ENDOGENOUS RETINOID DEFICIENCY
  申请人：QLT, Inc.

  公开号：EP2563350A2

  公开（公告）日：2013-03-06
• [EN] THERAPEUTIC REGIMEN AND METHOD FOR TREATING OR AMELIORATING VISUAL DISORDERS ASSOCIATED WITH AN ENDOGENOUS RETINOID DEFICIENCY<br/>[FR] RÉGIME ET PROCÉDÉ THÉRAPEUTIQUE POUR LE TRAITEMENT OU L'AMÉLIORATION DE TROUBLES DE LA VUE ASSOCIÉS À UNE CARENCE EN RÉTINOÏDES ENDOGÈNES
  申请人：QUADRA LOGIC TECH INC

  公开号：WO2011132084A2

  公开（公告）日：2011-10-27

  Disclosed herein are therapeutic regimens for treating or ameliorating a visual disorder associate with an endogenous retinoid deficiency in a subject by administering a therapeutically effective amount of a synthetic retinal derivative or a pharmaceutically acceptable composition comprising a synthetic retinal derivative according to the therapeutic regimen which leads to local recovery of visual functions such as visual fields, visual acuity and retinal sensitivity, among others.