(2S,4S,4'R)-2',2'-二甲基[4,4'-联-1,3-二氧杂环戊烷]-2-甲醇 | 145354-78-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (2S,4S,4'R)-2',2'-二甲基[4,4'-联-1,3-二氧杂环戊烷]-2-甲醇
• 英文名称: ((2S,4S,4'R)-2',2'-Dimethyl-[4,4']bi[[1,3]dioxolanyl]-2-yl)-methanol
• 英文别名: [(2S,4S)-4-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1,3-dioxolan-2-yl]methanol
• CAS: 145354-78-5
• 化学式: C₉H₁₆O₅
• 分子量: 204.223
• InChiKey: ACRXATKXLFPSEO-RNJXMRFFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2S,4S,4'R)-2',2'-二甲基[4,4'-联-1,3-二氧杂环戊烷]-2-甲醇 在 ruthenium(IV) oxide 吡啶 、 sodium periodate 、 对甲苯磺酸 作用下， 以 甲醇 、 四氯化碳 、 二氯甲烷 、 水 、 乙腈 为溶剂， 生成 (2S,4S)-2-[(Benzoyloxy)methyl]-1,3-dioxolane-4-carboxylic acid
  参考文献：
  名称：

  Potent anti-HIV and anti-HBV activities of (−)-L-β-dioxolane-C and (+)-L-β-dioxolane-T and their asymmetric syntheses.

  摘要：

  The asymmetric syntheses of (+)-L-beta-dioxolane-T and (-)-L-beta-dioxolane-C were accomplished starting from 1,6-anhydro-L-beta-gulopyranose, and their anti-HIV and anti-HBV activities were evaluated in human PBM cells, CEM cells and 2.2.15 cells, respectively.

  DOI：

  10.1016/s0040-4039(00)60890-0
• 作为产物：
  描述：

  (R)-1-((2S,4S)-2-Hydroxymethyl-[1,3]dioxolan-4-yl)-ethane-1,2-diol 、 丙酮 在 对甲苯磺酸 作用下， 生成 (2S,4S,4'R)-2',2'-二甲基[4,4'-联-1,3-二氧杂环戊烷]-2-甲醇
  参考文献：
  名称：

  Potent anti-HIV and anti-HBV activities of (−)-L-β-dioxolane-C and (+)-L-β-dioxolane-T and their asymmetric syntheses.

  摘要：

  The asymmetric syntheses of (+)-L-beta-dioxolane-T and (-)-L-beta-dioxolane-C were accomplished starting from 1,6-anhydro-L-beta-gulopyranose, and their anti-HIV and anti-HBV activities were evaluated in human PBM cells, CEM cells and 2.2.15 cells, respectively.

  DOI：

  10.1016/s0040-4039(00)60890-0

文献信息

• Potent anti-HIV and anti-HBV activities of (−)-L-β-dioxolane-C and (+)-L-β-dioxolane-T and their asymmetric syntheses.
  作者：Hea O. Kim、Kirupathevy Shanmuganathan、Antonio J. Alves、Lak S. Jeong、J. Warren Beach、Raymond F. Schinazi、Chang Chien-Neng、Cheng Yung-Chi、Chung K. Chu

  DOI：10.1016/s0040-4039(00)60890-0

  日期：1992.11

  The asymmetric syntheses of (+)-L-beta-dioxolane-T and (-)-L-beta-dioxolane-C were accomplished starting from 1,6-anhydro-L-beta-gulopyranose, and their anti-HIV and anti-HBV activities were evaluated in human PBM cells, CEM cells and 2.2.15 cells, respectively.