Synthesis of 4-substituted prolines as conformationally constrained amino acid analogs
作者:Ari M. P. Koskinen、Henry Rapoport
DOI:10.1021/jo00269a022
日期:1989.4
KOSKINEN, ARI M. P.;RAPOPORT, HENRY, J. ORG. CHEM., 54,(1989) N, C. 1859-1866
作者:KOSKINEN, ARI M. P.、RAPOPORT, HENRY
DOI:——
日期:——
Synthesis of Conformationally Constrained Lysine Analogues
作者:Rakesh Ganorkar、Amarnath Natarajan、Ahmed Mamai、José S. Madalengoitia
DOI:10.1021/jo060210f
日期:2006.6.1
The synthesis of two conformationallyconstrained lysine analogues is reported. The synthesis of the novel analogue 1 based on the 3-aza-bicyclo[3.1.0]hexane system is accomplished from the known tricycle 3 in eight steps. The synthesis of the analogue 2 is accomplished in eight steps from 4-hydroxy proline. Both analogues are synthesized appropriately protected for Fmoc/Boc solid-phase peptide synthesis