(5S)-四氢-5-甲基-2H-吡喃-2-酮 | 1121-72-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 中文名称: (5S)-四氢-5-甲基-2H-吡喃-2-酮
• 英文名称: (-)-(5S)-5-methyl-tetrahydropyran-2-one
• 英文别名: (S)-5-methyl-tetrahydropyran-2-one；(S)-(-)-4-Methyl-δ-valerolacton；4(S)-methyl-δ-pentyllactone；2H-Pyran-2-one, tetrahydro-5-methyl-, (5S)-；(5S)-5-methyloxan-2-one
• CAS: 1121-72-8
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: GQUBDAOKWZLWDI-YFKPBYRVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2932999099

反应信息

• 作为反应物：
  描述：

  (5S)-四氢-5-甲基-2H-吡喃-2-酮 生成 (S)-2-甲基戊二酸
  参考文献：
  名称：

  Schreiber,K., Justus Liebigs Annalen der Chemie, 1965, vol. 682, p. 219 - 227

  摘要：

  DOI：
• 作为产物：
  描述：

  丙二酸二乙酯 、 (R)-1-(1-Ethoxy-ethoxy)-3-iodo-2-methyl-propane 在 sodium hydride 、 sodium chloride 作用下， 以 四氢呋喃 、 水 、 二甲基亚砜 为溶剂， 以81%的产率得到(5S)-四氢-5-甲基-2H-吡喃-2-酮
  参考文献：
  名称：

  第一次全合成抗有丝分裂化合物，（+）-phomopsidin。

  摘要：

  [反应：见正文]通过非对映选择性的跨环Diels-Alder（TADA）反应，实现了（+）-磷酸抗霉菌素的第一个全合成。合成的关键步骤包括用（-）-α-pine烯和9-BBN进行非对映选择性的炔酮还原，通过E-选择性分子内Horner-Wadsworth-Emmons（HWE）反应进行大环化，以及在Wipf条件下进行碳金属化，然后进行HWE反应在低温下选择性地构建（E）-1-甲基丙烯基和（1E，2E）-4-羧基-1,3-丁二烯基取代基。

  DOI：

  10.1021/ol036338q

文献信息

• Concise asymmetric synthesis of two natural oxacyclododecindione-type macrolactones from industrial waste
  作者：Xian Liu、Huifang Nie、Lin Yao、Ru Jiang、Weiping Chen

  DOI：10.1039/d0ra02994g

  日期：——

  (S)-5-Methyl-tetrahydropyran-2-one 1 is a by-product in the production of key intermediates of steroidal hormones. Asymmetric synthesis of natural oxacyclododecindione-type macrolactones 2 and 3 has been realized for the first time from (S)-1 in seven and eight steps with 37% and 27% overall yield, respectively.

  ( S )-5-Methyl-tetrahydropyran-2-one 1是生产甾体激素关键中间体的副产品。首次从 ( S ) -1分 7 步和 8 步实现了天然氧杂环十二烷二酮型大环内酯2和3的不对称合成，总收率分别为 37% 和 27%。
• PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO
  申请人：Incyte Corporation

  公开号：US20150344497A1

  公开（公告）日：2015-12-03

  This invention relates to processes for preparing a JAK1 inhibitor having Formula Ia: as well as new forms of the inhibitor.

  这项发明涉及制备具有Ia式的JAK1抑制剂的过程，以及该抑制剂的新形式。
• (METH)ACRYLATE COMPOUND, (METH)ACRYLIC COPOLYMER AND PHOTOSENSITIVE RESIN COMPOSITION CONTAINING SAME
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20160347896A1

  公开（公告）日：2016-12-01

  The present invention provides a resist or a compound for use as a resist, which is highly sensitive and well-balanced without losing the fundamental physical properties required as a chemically amplified resist (e.g., resolution, line edge roughness (LER)). The present invention is directed to a (meth)acrylate compound represented by general formula (1) and a process for preparation thereof, as well as a (meth)acrylic copolymer obtainable by polymerization of the (meth)acrylate compound of general formula (1) and a photosensitive resin composition thereof: (wherein R 1 represents a hydrogen atom or a methyl group, R 2 represents a linear or branched alkyl group containing 2 to 4 carbon atoms, and each R 3 may be the same or different and represents a group represented by the following formula (2) or (3), etc.) (provided that formulae (2) and (3) are as defined in the specification of the present application).
• 9-MEMBERED FUSED RING DERIVATIVE
  申请人：Shionogi & Co., Ltd.

  公开号：US20180079727A1

  公开（公告）日：2018-03-22

  The purpose of the present invention is to provide novel compounds having ACC2 selective inhibitory activity. In addition, the present invention provides a pharmaceutical composition comprising the compound. A compound of Formula: or its pharmaceutically acceptable salt, wherein, R 1 is substituted or unsubstituted fused aromatic heterocyclyl represented by Formula: wherein, ring B is 5-membered ring, ring C is 6-membered ring; ring A is substituted or unsubstituted non-aromatic carbocycle or the like; -L 1 - is —O—(CR 6 R 7 )m- or the like; -L 2 - is —O—(CR 6 R 7 )n- or the like; each R 6 is independently hydrogen or the like; each R 7 is independently hydrogen or the like; each m is independently an integer of 0, 1, 2 or 3; each n is independently an integer of 1, 2 or 3; R 2 is substituted or unsubstituted alkyl; R 3 is hydrogen or substituted or unsubstituted alkyl; R 4 is substituted or unsubstituted alkylcarbonyl or the like.
• US9802957B2
  申请人：——

  公开号：US9802957B2

  公开（公告）日：2017-10-31