(9Z)-9-benzylidenetricyclo[5.2.1.02,6]decan-8-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (9Z)-9-benzylidenetricyclo[5.2.1.02,6]decan-8-one
• 化学式: C₁₇H₁₈O
• 分子量: 238.32
• InChiKey: XWQLLRNEKFJKDX-DHDCSXOGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Photostable cosmetic light screening compositions
  申请人：GIVAUDAN-ROURE (INTERNATIONAL) S.A.

  公开号：EP0754445A2

  公开（公告）日：1997-01-22

  The invention relates to photostable, cosmetic light-screening compositions for the protection of the human epidermis and the hairs against the ultraviolet rays of wavelengths between 320 and 400 nm, and between 290 and 400 nm respectively. In particular, it relates to such compositions which comprise, in a cosmetically acceptable vehicle containing at least one fatty phase, about 0,75, to about 5 %, in particular about 1 to about 4 % by weight, of a dibenzoylmethane type UV-A screening agent and at least about 0,5 % to about 2 %, in particular about 0,5 to about 1 % by weight, of a benzylidene type stabiliser of the general formula    represents a bridged cyclic compound having the camphor (1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-one), norcamphor (bicyclo[2.2.1]heptan-2-one), nopinone (6,6-dimethyl-bicyclo[3.1.1]heptan-2-one), pinocamphone (4,6,6-trimethyl-bicyclo[3.1.1]heptan-3-one), verbanone (4,6,6-trimethyl-bicyclo[3.1.1]heptan-2-one, thujone (1-isopropyl-4-methyl-bicyclo[3.1.0] hexan-3-one) or the 4,7-methano-octahydro-inden-5-one structure, and wherein R1, R2, R3 independently signify hydrogen, lower alkyl, lower alkoxy, or 2 adjacent radicals represent methylenedioxy, and where, in case of the camphor derivatives, the ratio of the UV-A filter to the stabiliser is greater than ca.1,5 : 1, preferably ca. 2 to ca. 6 : 1, and where 4-methylbenzylidene camphor is excluded from the scope of formula I, and, optionally, at least one conventional UV-B filter.

  本发明涉及光稳定性化妆品遮光组合物，用于保护人体表皮和毛发免受波长分别为 320 至 400 纳米和 290 至 400 纳米的紫外线的伤害。 具体而言，它涉及这样的组合物：在含有至少一种脂肪相的化妆品可接受载体中，包含约 0.75%至约 5%，特别是约 1%至约 4%（按重量计）的二苯甲酰甲烷型紫外线-A 遮蔽剂，以及至少约 0.5%至约 2%（特别是约 0.5%至约 1%（按重量计））的亚苄基稳定剂，通式如下 代表一种桥式环状化合物，具有樟脑（1,7,7-三甲基-双环[2.2.1]庚-2-酮）、去樟脑（双环[2.2.1]庚-2-酮）、茚酮（6,6-二甲基-双环[3.1.1.1]庚-2-酮）、蒎烷酮（4,6,6-三甲基-双环[3.1.1]庚-3-酮）、马鞭酮（4,6,6-三甲基-双环[3.1.1]庚-2-酮）、��酮（1-异丙基-4-甲基-双环[3.其中 R1、R2、R3 独立表示氢、低级烷基、低级烷氧基，或 2 个相邻基表示亚甲基二氧基，如果是樟脑衍生物，则 UV-A 过滤器与稳定剂的比例大于约 1.5: 1，优选约 2 至约 6 : 1，且 4-甲基亚苄基樟脑不在式 I 的范围内，以及可选的至少一种常规 UV-B 过滤器。
• US5840282A
  申请人：——

  公开号：US5840282A

  公开（公告）日：1998-11-24