3-(6-chloro-pyridin-3-ylmethyl)-4-methyl-3H-thiazol-2-ylideneamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(6-chloro-pyridin-3-ylmethyl)-4-methyl-3H-thiazol-2-ylideneamine
• 英文别名: 3-[(6-Chloropyridin-3-yl)methyl]-4-methyl-1,3-thiazol-2-imine
• 化学式: C₁₀H₁₀ClN₃S
• 分子量: 239.728
• InChiKey: IOERUHWUYPCHLZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  65.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Heterocyclic compounds having effect of activating a4beta2 nicotinic acetylcholine receptors
  申请人：SUNTORY LIMITED

  公开号：US20020028809A1

  公开（公告）日：2002-03-07

  There is provided heterocyclic compounds of the following formula (I): 1 in which, A is optionally substituted aryl group or optionally substituted heterocyclic group; X is oxygen atom, sulfur atom, carbon atom or nitrogen atom; dotted line shows either presence or absence of bond; n is integer of 1 or 2; and Y represents alkylene bond and so on; or a pharmaceutically acceptable salt thereof. These compounds have good affinity to &agr;4&bgr;2 nicotinic acetylcholine receptors and activate the same to thereby exert a preventive or therapeutic effect on cerebral dysfunction.

  提供了以下式子（I）的杂环化合物：1其中，A是可选择取代的芳基或可选择取代的杂环基；X是氧原子、硫原子、碳原子或氮原子；虚线表示键的存在或不存在；n是1或2的整数；Y表示烷基键等；或其药学上可接受的盐。这些化合物与α4β2型尼古丁乙酰胆碱受体具有良好的亲和力，并激活它们，从而对脑功能障碍产生预防或治疗作用。
• Tricyclic derivatives of 5,6-dihydro-11H-dibenzo(B,E)azepin-6-one having pharmacological avtivity, and method for their preparation
  申请人：A. Menarini S.a.S.

  公开号：EP0089322A1

  公开（公告）日：1983-09-21

  A pharmacologically active compound has the general formula in which R is a hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms; R, and R2, which can be different, represent a hydrogen atom, a hydroxyl group, an alkyl group, an alkoxy group, an arylalkyl group, or an arylalkoxy group, or can jointly represent an oxygen atom or a CHCOOR,' group where R1' is a hydrogen atom or an alkyl group; and R3 represents a hydrogen or halogen atom or an alkyl, NH2, NO2, NHCO-alkyl, NHCO-aryl, NHCONH-alkyl or NHCONH-aryl group. These compounds act on the central nervous system and have an anti-convulsant sedative activity.

  一种具有药理活性的化合物具有通式，其中 R 是氢原子或含有 1 至 4 个碳原子的烷基；R 和 R2 可以不同，分别代表氢原子、羟基、烷基、烷氧基、芳基烷基或芳基烷氧基，也可以共同代表氧原子或 CHCOOR，'基团，其中 R1' 是氢原子或烷基；R3 代表氢原子或卤素原子或烷基、NH2、NO2、NHCO-烷基、NHCO-芳基、NHCONH-烷基或 NHCONH-芳基。 这些化合物作用于中枢神经系统，具有抗惊厥镇静活性。
• HETEROCYCLIC COMPOUNDS HAVING EFFECT OF ACTIVATING NICOTINIC ACETYLCHOLINE $g(a)4$g(b)2 RECEPTOR
  申请人：SUNTORY LIMITED

  公开号：EP1176141A1

  公开（公告）日：2002-01-30

  There is provided heterocyclic compounds of the following formula (I):    in which, A is optionally substituted aryl group or optionally substituted heterocyclic group; X is oxygen atom, sulfur atom, carbon atom or nitrogen atom; dotted line shows either presence or absence of bond; n is integer of 1 or 2; and Y represents alkylene bond and so on; or a pharmaceutically acceptable salt thereof. These compounds have good affinity to α4β2 nicotinic acetylcholine receptors and activate the same to thereby exert a preventive or therapeutic effect on cerebral dysfunction.

  提供了下式(I)的杂环化合物：其中，A为任选取代的芳基或任选取代的杂环基团；X为氧原子、硫原子、碳原子或氮原子；虚线表示存在或不存在键；n为1或2的整数；Y代表烯键等，或其药学上可接受的盐。 这些化合物对α4β2烟碱乙酰胆碱受体具有良好的亲和力，并能激活该受体，从而对脑功能障碍起到预防或治疗作用。
• (N-(pyridinylmethyl)-heterocyclic)-ylideneamine compounds as nicotinic acetylcholine receptor binding agents
  申请人：PFIZER INC.

  公开号：EP0857725B1

  公开（公告）日：2001-07-25
• PROCESS FOR THE PREPARATION OF 10,11-DIHYDRO-5H-DIBENZO A,D]CYCLOHEPT-5-ENES AND DERIVATIVES THEREOF
  申请人：ROLABO S.L.

  公开号：EP0970050B1

  公开（公告）日：2001-10-24