(Z)-十八碳-9-烯酸[1-[(甘油氧基-羟基-磷酰)氧基甲基]-2-[(E)-十八碳-9-烯酰基]氧基-乙基]酯 | 62700-69-0

• 物质功能分类: 有机原料 - 醇、酚、酚醇类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 中文名称: (Z)-十八碳-9-烯酸[1-[(甘油氧基-羟基-磷酰)氧基甲基]-2-[(E)-十八碳-9-烯酰基]氧基-乙基]酯
• 英文名称: 1,2-dioleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]
• 英文别名: Dioleoylphosphatidylglycerol；[(2R)-3-[2,3-dihydroxypropoxy(hydroxy)phosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
• CAS: 62700-69-0
• 化学式: C₄₂H₇₉O₁₀P
• 分子量: 775.057
• InChiKey: DSNRWDQKZIEDDB-GCMPNPAFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  12.5
• 重原子数：
  53
• 可旋转键数：
  42
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  (Z)-十八碳-9-烯酸[1-[(甘油氧基-羟基-磷酰)氧基甲基]-2-[(E)-十八碳-9-烯酰基]氧基-乙基]酯 、 sodium hydroxide 生成 二油酰磷脂酰甘油钠盐
  参考文献：
  名称：

  KASHIRICHEVA, I. I.;MISHINA, I. M.;FEDOROVA, G. A.;VASILENKO, I. A.;SHVET+, XIM.-FARMATS. ZH., 22,(1988) N 4, 494-499

  摘要：

  DOI：
• 作为产物：
  描述：

  calcium;[(2R)-2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl] 2,3-dihydroxypropyl phosphate 、 盐酸 生成 (Z)-十八碳-9-烯酸[1-[(甘油氧基-羟基-磷酰)氧基甲基]-2-[(E)-十八碳-9-烯酰基]氧基-乙基]酯
  参考文献：
  名称：

  KASHIRICHEVA, I. I.;MISHINA, I. M.;FEDOROVA, G. A.;VASILENKO, I. A.;SHVET+, XIM.-FARMATS. ZH., 22,(1988) N 4, 494-499

  摘要：

  DOI：

文献信息

• Nanoalum particles comprising a PAA sizing agent
  申请人：Infectious Disease Research Institute

  公开号：US11173126B2

  公开（公告）日：2021-11-16

  Provided herein are nanoalum particles comprising an aluminum salt and a sizing agent, wherein the size of the particle ranges from about 1 nm to 450 nm. Such nanoalum particles are stable and are amenable to a terminal sterilization step prior to vialing. Compositions comprising the nanoalum particles, and the making and using of the nanoalum particles are also provided.

  本文提供的纳米铝颗粒由一种铝盐和一种施胶剂组成，其中颗粒的尺寸范围为约 1 纳米至 450 纳米。这种纳米铝颗粒是稳定的，可在装瓶前进行终端灭菌步骤。此外，还提供了包含纳米铝颗粒的组合物以及纳米铝颗粒的制造和使用方法。
• Synthesis of phospholipid-inhibitor conjugates by enzymic transphosphatidylation with phospholipase D
  作者：Peng Wang、Matthias Schuster、Yi Fong Wang、Chi Huey Wong

  DOI：10.1021/ja00076a004

  日期：1993.11

  This paper describes an efficient enzymatic procedure for the synthesis of phospholipid--inhibitor conjugates. The chemoselectivity, regioselectivity, and stereoselectivity of phospholipase-D-catalyzed phosphatidylations were investigated, and phospholipids containing inhibitors such as azasugars, nucleosides, and peptides were synthesized. These phospholipid conjugates in aqueous solution generally form liposome bilayers with multivalent inhibitors (the head groups) displayed on the surface and may find use in drug delivery and targeting. They also exhibit interesting structural features in different solvent systems as indicated in the NMR spectra.
• KASHIRICHEVA, I. I.;MISHINA, I. M.;FEDOROVA, G. A.;VASILENKO, I. A.;SHVET+, XIM.-FARMATS. ZH., 22,(1988) N 4, 494-499
  作者：KASHIRICHEVA, I. I.、MISHINA, I. M.、FEDOROVA, G. A.、VASILENKO, I. A.、SHVET+

  DOI：——

  日期：——
• ARTIFICIAL LIPID-POLYMER-DNA COMPLEX, BIOIMAGING AGENT AND PREPARATION METHOD THEREOF
  申请人：Research & Business Foundation SUNGKYUNKWAN UNIVERSITY

  公开号：US20140364596A1

  公开（公告）日：2014-12-11

  An artificial lipid-polymer-DNA complex, an in-vivo imaging agent, a pharmaceutical composition and a method of preparing the same are provided. The artificial lipid bilayer includes a polymer matrix including polylactic-co-glycolic acid disposed within a lipid membrane.
• LIPOSOMAL FORMULATIONS COMPRISING SAPONIN AND METHODS OF USE
  申请人：Infectious Disease Research Institute

  公开号：US20200276299A1

  公开（公告）日：2020-09-03

  Provided herein are liposomal formulations containing saponin and optionally, a lipopolysaccharide. Also provided IC herein are pharmaceutical compositions and vaccine compositions comprising the liposomal formulations and an antigen. The pharmaceutical compositions and vaccine compositions are capable of eliciting or enhancing of an immune response, for example, for vaccine or therapeutic uses. Compositions and methods related to making the liposomal formulations and using the liposomal formulations for eliciting or enhancing an immune response are also provided.