异牡荆素鼠李糖苷 | 64820-99-1

• 物质功能分类: 生物化工 - 中草药成分
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 异牡荆素鼠李糖苷
• 中文别名: 牡荆素-2-O-鼠李糖苷；牧荆葡基黄酮-2''-O-鼠李糖苷；5,7,4`-三羟基黄酮-8-C-Beta-D-葡萄糖苷；牡荆素鼠李糖苷；牡荆素-2''-O-鼠李糖苷
• 英文名称: Vitexin 2''-O-rhamnoside
• 英文别名: 8-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one
• CAS: 64820-99-1
• 化学式: C₂₇H₃₀O₁₄
• 分子量: 578.5
• InChiKey: LYGPBZVKGHHTIE-HUBYJIGHSA-N

物化性质

• 熔点：
  215°C
• 沸点：
  898.8±65.0 °C(Predicted)
• 密度：
  1.74±0.1 g/cm3(Predicted)
• 溶解度：
  DMSO（少许）、水（少许）
• LogP：
  1.860 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  41
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  236
• 氢给体数：
  9
• 氢受体数：
  14

安全信息

• WGK Germany：
  3
• 海关编码：
  29389090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

制备方法与用途

生物活性

Vitexin-2"-O-rhamnoside 是刺梨（Cratagus pinnatifida Bge）中一种主要的黄酮苷类化合物，能够对由H₂O₂介导的氧化应激损伤提供保护作用，适用于心血管系统疾病的研宄。

化学性质

Vitexin-2"-O-rhamnoside 为黄色结晶粉末，易溶于甲醇。它来源于山楂叶，是蔷薇科山楂属植物“山里红”的提取物。

用途

主要用于含量测定、鉴定及药理实验等。

药理药效

牡荆素鼠李糖苷对离体动脉环具有浓度依赖性的舒张作用，该作用通过内皮依赖性和内皮非依赖的方式产生，并表现出部分钙拮抗剂的药理作用特点。因此，它可用于心脑血管疾病治疗药物的制备。

用途

作为草药产品分析的标准品。

文献信息

• COMPOSITION COMPRISING NUTGALL EXTRACT AND FRAXIN AS ACTIVE INGREDIENT FOR IMPROVEMENT OF COGNITIVE ABILITY AND FOR PREVENTION OR TREATMENT OF DEMENTIA AND HYPERACTIVITY DISORDER
  申请人：Kim, Sang Hee

  公开号：EP3900732A1

  公开（公告）日：2021-10-27

  The present invention relates to a composition for improving cognitive ability, and preventing or treating dementia and a hyperactivity disorder, which includes a Galla rhois extract and fraxin as active ingredients. It was identified that the composition including the Galla rhois extract and fraxin significantly improves cognitive memory in an Alzheimer's disease model induced by Aβ (1-42) administration and an APPswe/PS1dE9 double-expressing Alzheimer's disease model, and inhibits the generation of amyloid plaques, suggesting the usefulness of the combination of the Galla rhois extract and fraxin, as a therapeutic material, against Alzheimer's disease, and showing that the combination of the Galla rhois extract and fraxin is able to be used as a therapeutic agent for ADHD

  本发明涉及一种用于改善认知能力、预防或治疗痴呆症和多动症的组合物，其活性成分包括高良姜提取物和fraxin。研究发现，包括高良姜提取物和fraxin的组合物能显著改善Aβ（1-42）给药诱导的阿尔茨海默病模型和APPswe/PS1dE9双表达阿尔茨海默病模型的认知记忆，并抑制淀粉样斑块的生成、表明五倍子提取物和弗莱鑫的组合作为一种治疗材料，对阿尔茨海默病很有用，并表明五倍子提取物和弗莱鑫的组合可用作多动症的治疗剂
• USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS
  申请人：Prendergast, Patrick Thomas

  公开号：EP1223928A2

  公开（公告）日：2002-07-24
• PROCESS FOR PREPARING A PLANT EXTRACT OF PASSIFLORA ALATA AND USE OF SAID EXTRACT IN COSMETIC AND PHARMACEUTICAL COMPOSITIONS
  申请人：Natura Cosméticos S.A.

  公开号：EP2185166B1

  公开（公告）日：2015-11-11
• Process for Preparing a Plant Extract of Passiflora Alata and Use of Said Extract in Cosmetic and Pharmaceutical Compositions
  申请人：Gesztesi Jean-Luc

  公开号：US20110135774A1

  公开（公告）日：2011-06-09

  The present invention relates to the use of plant extracts of Passiflora alata as an anti-inflammatory agent in cosmetic and pharmaceutical compositions. The present invention further relates to a process for obtaining a plant extract of Passiflora alata comprising the steps of submitting the leaves of the Passiflora alata plants to an extraction with water to obtain an aqueous extract and submitting the aqueous extract thus obtained to at least one elution with an aqueous solution of ethanol in a specific column and later drying of said extract by spray-drying.
• US6555523B1
  申请人：——

  公开号：US6555523B1

  公开（公告）日：2003-04-29