异脱水淫羊霍素 | 28610-30-2

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 异脱水淫羊霍素
• 中文别名: 异去氢淫羊藿素
• 英文名称: isoanhydroicaritin
• 英文别名: 3,5-dihydroxy-2-(4-hydroxyphenyl)-7-methoxy-8-(3-methylbut-2-enyl)chromen-4-one
• CAS: 28610-30-2
• 化学式: C₂₁H₂₀O₆
• 分子量: 368.386
• InChiKey: RJANATGWWPNKAL-UHFFFAOYSA-N

物化性质

• 熔点：
  275℃
• 沸点：
  610.4±55.0 °C(Predicted)
• 密度：
  1.359±0.06 g/cm3 (20 ºC 760 Torr)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  96.2
• 氢给体数：
  3
• 氢受体数：
  6

制备方法与用途

生物活性方面，isoanhydroicaritin 是一种从干燥的扶芳藤根中分离出的黄酮类化合物。

文献信息

• GENE NETWORK-BASED METHOD FOR CONFIRMING DRUG ACTION
  申请人：Tsinghua University

  公开号：EP2369493A1

  公开（公告）日：2011-09-28

  The invention provides a network-based method for confirming drug action(drug effect, synergistic reaction). The method be carried out by mapping a first drug genes/gene products subset and a second genes/gene products subset in a gene network. The second genes/gene products subset can be a second drug genes/gene products subset or a biological process genes/gene products subset. The invention also provides a tool for pre-clinical drug screening.

  本发明提供了一种基于网络的确认药物作用（药物效应、协同反应）的方法。该方法通过在基因网络中绘制第一药物基因/基因产物子集和第二基因/基因产物子集来实现。第二基因/基因产物子集可以是第二药物基因/基因产物子集，也可以是生物过程基因/基因产物子集。本发明还为临床前药物筛选提供了一种工具。
• AIR FRESHENER COMPOSITION AND PREPARATION METHOD THEREFOR
  申请人：Wang, Jingning

  公开号：EP3388137A1

  公开（公告）日：2018-10-17

  The present invention relates to the field of air cleaning, and specifically discloses an air freshener composition. The air freshener composition comprises component A and component B, wherein a weight ratio of the component A to the component B is 1: 0.5-3; the component A comprises, in parts by weight, 10-30 parts by weight of an active agent; 6-15 parts by weight of a carrier; 1-4 parts by weight of a pH regulator; and 0.01-0.2 part by weight of an antioxidant; the component B is a plant extract solution, wherein the plant extract solution comprises at least, in parts by weight: 5-30 parts by weight of an extract of a mixture of Populus nigra var. italica, grapefruit peels and eucalyptus leaves; 0.1-5 parts by weight of Sophora flavescens extract; 1-3 parts by weight of Aloe vera extract; 1-10 parts by weight of fresh orange peel extract; 0.5-3 parts by weight of Nandina domestica extract; 0.5-10 parts by weight of Eucalyptus robusta Smith extract; 1-8 parts by weight of Robinia pseudoacacia L. extract; 1-5 parts by weight of Chrysanthemum morifolium extract; and 0.1-2 parts by weight of artemisinin.

  本发明涉及空气清洁领域，具体公开了一种空气清新剂组合物。该空气清新剂组合物包括组分 A 和组分 B，其中组分 A 与组分 B 的重量比为 1：0.5-3；组分 A 按重量份数计包括：10-30 份活性剂；6-15 份载体；1-4 份 pH 值调节剂；以及 0.01-0.2 份抗氧化剂；组分 B 为植物提取物溶液，其中植物提取物溶液按重量份数计至少包括：5-30 份黑杨变种、葡萄柚皮和桉树叶的混合物提取物；0.1-5 份桉树叶提取物（按重量份数计）；0.1-0.2 份桉树叶提取物（按重量份数计）；0.1-0.3 份桉树叶提取物（按重量份数计）；0.1-0.4 份桉树叶提取物（按重量份数计）；0.1-0.5 份桉树叶提取物（按重量份数计）。italica、柚子皮和桉树叶的混合物的提取物；0.1-5 份（按重量份数计）白槐提取物；1-3 份（按重量份数计）芦荟提取物；1-10 份（按重量份数计）鲜橙皮提取物；0.5-3 份（按重量份数计）南丹提取物；0.5-10 份（按重量计）桉树提取物；1-8 份（按重量计）洋槐提取物；1-5 份（按重量计）菊花提取物；以及 0.1-2 份（按重量计）青蒿素。
• NOVEL AIR PURIFICATION COMPOSITION HAVING ANTIVIRAL AND BACTERICIDAL FUNCTIONS
  申请人：Wang, Jingning

  公开号：EP3650105A1

  公开（公告）日：2020-05-13

  Disclosed is a novel air purification composition with antiviral and bactericidal functions, the composition at least comprising the following components in percentage by weight: 0.3%-1% of a black poplar essential oil, 0.1%-1% of a tea tree essential oil, 0.1%-0.5% of a Cupressus funebris essential oil, 0.1%-1% of an Artemisia apiacea essential oil, 0.1%-10% of a Sophora flavescens extract, 0. 1%-5% of a ginger extract, 5%-30% of a Cupressus funebris hydrolate, 0.5%-1% of a hyperbranched amino polymer, 0.5%-5% of a surfactant, and the balance being water.

  本发明公开了一种具有抗病毒和杀菌功能的新型空气净化组合物，该组合物按重量百分比至少包括以下成分：0.3%-1%的黑杨精油、0.1%-1%的茶树精油、0.1%-0.1%-5%的生姜提取物，5%-30%的冲天香水合物，0.5%-1%的超支化氨基酸聚合物，0.5%-5%的表面活性剂，余量为水。
• Air freshener composition and preparation method thereof
  申请人：Wang Jingning

  公开号：US10744219B2

  公开（公告）日：2020-08-18

  The present invention relates to the field of air cleaning, and specifically discloses an air freshener composition. The air freshener composition comprises component A and component B, wherein a weight ratio of the component A to the component B is 1:0.5-3; the component A comprises, in parts by weight, 10-30 parts by weight of an active agent; 6-15 parts by weight of a carrier; 1-4 parts by weight of a pH regulator; and 0.01-0.2 part by weight of an antioxidant; the component B is a plant extract solution, wherein the plant extract solution comprises at least, in parts by weight: 5-30 parts by weight of an extract of a mixture of Populus nigra var. italica, grapefruit peels and eucalyptus leaves; 0.1-5 parts by weight of Sophora flavescens extract; 1-3 parts by weight of Aloe vera extract; 1-10 parts by weight of fresh orange peel extract; 0.5-3 parts by weight of Nandina domestica extract; 0.5-10 parts by weight of Eucalyptus robusta Smith extract; 1-8 parts by weight of Robinia pseudoacacia L. extract; 1-5 parts by weight of Chrysanthemum morifolium extract; and 0.1-2 parts by weight of artemisinin.

  本发明涉及空气净化领域，具体公开了一种空气清新剂组合物。该空气清新剂组合物由组分 A 和组分 B 组成，其中组分 A 与组分 B 的重量比为 1:0.5-3；组分 A 按重量份数计包括：10-30 份活性剂；6-15 份载体；1-4 份 pH 值调节剂；以及 0.01-0.2 份抗氧化剂；组分 B 为植物提取物溶液，其中植物提取物溶液按重量份数计至少包括：5-30 份黑杨变种、柚子皮和桉树叶的混合物提取物；0.1-5 份桉树叶提取物（按重量份数计）；0.1-0.2 份桉树叶提取物（按重量份数计）；0.1-0.3 份桉树叶提取物（按重量份数计）；0.1-0.4 份桉树叶提取物（按重量份数计）；0.1-0.5 份桉树叶提取物（按重量份数计）。italica、柚子皮和桉树叶的混合物的提取物；0.1-5 份（按重量份数计）白槐提取物；1-3 份（按重量份数计）芦荟提取物；1-10 份（按重量份数计）鲜橙皮提取物；0.5-3 份（按重量份数计）南丹提取物；0.5-10 份（按重量计）桉树提取物；1-8 份（按重量计）洋槐提取物；1-5 份（按重量计）菊花提取物；以及 0.1-2 份（按重量计）青蒿素。
• Pharmaceutical compositions and methods for countering chemotherapy induced cardiotoxicity
  申请人：Auransa Inc.

  公开号：US10806716B2

  公开（公告）日：2020-10-20

  This disclosure provides methods and pharmaceutical compositions for reducing or eliminating cardiotoxicity, particularly cardiotoxicity induced by a cancer treatment or other therapy. In some cases, the methods and compositions prevent or reduce cardiotoxicity caused by anthracycline treatment. The methods provided herein often comprise administering a protective agent such as myricetin, tricetin, robinetin, ficetin, vitexin, quercetin, dihydrorobinetin, kaempferol, 7,3′,4′,5′-tetrahydroxyflavone, and myricitrin in conjunction with the administration of a cancer drug or other treatment. They may comprise administering a protective agent in combination with dexrazoxane. The compositions provided herein include co-formulations of a protective agent with a different protective agent or with a cancer treatment (e.g., anthracycline drug).

  本公开提供了减少或消除心脏毒性，特别是由癌症治疗或其他疗法引起的心脏毒性的方法和药物组合物。在某些情况下，这些方法和组合物可以预防或减少蒽环类药物治疗引起的心脏毒性。本文提供的方法通常包括在施用抗癌药物或其他疗法的同时施用一种保护剂，如麦角黄素、三黄素、洋槐黄素、黄荆素、槲皮素、二氢洋槐黄素、山柰酚、7,3′,4′,5′-四羟基黄酮和麦角黄素。它们可以包括将保护剂与右雷佐生联合使用。本文提供的组合物包括一种保护剂与另一种保护剂或与一种癌症治疗药物（如蒽环类药物）的共同制剂。