1,1-二溴-2-(2-喹啉基)-1-乙烯 | 218902-66-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 1,1-二溴-2-(2-喹啉基)-1-乙烯
• 英文名称: 1,1-dibromo-2-(2-quinolyl)-1-ethene
• 英文别名: 1,1-dibromo-2-(2-quinolyl)-ethylene；1,1-dibromo-2-(2-quinolyl)ethene；2-(2,2-Dibromovinyl)quinoline；2-(2,2-dibromoethenyl)quinoline
• CAS: 218902-66-0
• 化学式: C₁₁H₇Br₂N
• 分子量: 312.991
• InChiKey: MTHMFZDCFWZPIR-UHFFFAOYSA-N

物化性质

• 沸点：
  367.8±27.0 °C(Predicted)
• 密度：
  1.869±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,1-二溴-2-(2-喹啉基)-1-乙烯 在 正丁基锂 作用下， 生成 2-乙炔喹啉
  参考文献：
  名称：

  Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections

  摘要：

  We report the synthesis of substituted quinolines and their in vitro biological evaluation against the causal agents of cutaneous leishmaniasis, visceral leishmaniasis, African trypanosomiasis and Chagas' disease. Furthermore, several quinolines have also been tested for their anti-retroviral activity in HIV-1 infected cells. The structure activity relationships of these new synthetic compounds are discussed and emphasis was placed on the treatment of leishmania/HIV co-infections. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2003.09.007
• 作为产物：
  描述：

  喹啉-2-甲醛 、 四溴化碳 在 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 1,1-二溴-2-(2-喹啉基)-1-乙烯
  参考文献：
  名称：

  钯催化乙烯基溴化物，三氟甲磺酸酯，甲苯磺酸酯和壬酸酯的二氟甲基化

  摘要：

  描述了在温和条件下二，三或四取代乙烯基溴，三氟甲磺酸酯，甲苯磺酸酯和壬二酸酯的钯催化二氟甲基化。该反应可耐受各种官能团，例如溴化物，氯化物，氟化物，酯，胺，腈和受保护的羰基，因此提供了制备二氟甲基化烯烃的一般途径。

  DOI：

  10.1002/chem.201500551

文献信息

• Substituted quinolines for the treatment of protozoa and retrovirus co-infections
  申请人：Fakhfakh Mohamed

  公开号：US20050165052A1

  公开（公告）日：2005-07-28

  The invention relates to the use of quinolines having general formula (1), wherein R 1 denotes H; alkyl C 1 -C 15 ; alkenyl or alkynyl C 2 -C 15 ; —CHO; heteroaryl; alkyl C 1 -C 15 or alkenyl or alkynyl C 2 -C 7 comprising at least one substituent selected from among O, halogen, —OH, —CHO, —COOH, aryloxycarbonyl, alkyloxycarbonyl C 2 -C 8 , alkenyloxycarbonyl C 3 -C 9 , nitrile, aryl, heteroaryl, arylsulphone, alkylsulphone C 1 -C 7 , thioalkyl or aminoalkyl C 1 -C 7 ; alkenyl C 2 -C 7 bearing at least one substituent selected from among NH 2 , aleoxy C 1 -C 7 , phenoxy, cycloakyl C 3 -C 6 or heteroaryloxy, alkenyl or alkynyl C 2 -C 15 comprising at least one trialkylsilyl C 1 -C 7 ; R 2 , in position 3, 6 or 8, denotes H; halogen; —OH; —CHO; —COOH; alkyl or aleoxy C 1 -C 7 ; —NH2; alkenyl C 2 -C 7 ; or alkynyl C 2 -C 10 ; R 1 and R 2 do not both denote H. The invention is used for the preparation of a medicine to treat protozoan and retrovirus co-infections.

  本发明涉及使用通式（1）的喹啉，其中R1表示H; 烷基C1-C15; 烯基或炔基C2-C15; -CHO; 杂环芳基; 烷基C1-C15或烯基或炔基C2-C7，包括至少一种取代基，所述取代基从O，卤素，-OH，-CHO，-COOH，芳基氧羰基，烷氧羰基C2-C8，烯基氧羰基C3-C9，腈，芳基，杂环芳基，芳基磺酰基，烷基磺酰基C1-C7，硫代烷基或氨基烷基C1-C7中选择; 烯基C2-C7具有从NH2，烷氧基C1-C7，苯氧基，环烷基C3-C6或杂环氧基，烯基或炔基C2-C15包括至少一个三烷基硅基C1-C7; R2，在位置3、6或8，表示H; 卤素; -OH; -CHO; -COOH; 烷基或烷氧基C1-C7; -NH2; 烯基C2-C7; 或炔基C2-C10; R1和R2不能同时表示H。该发明用于制备治疗原虫和逆转录病毒共感染的药物。
• PREPARATION OF QUINOLINES SUBSTITUTED AT THE 2 OR 3 POSITION BY AN ALKENYL OR ALKYNYL CHAIN
  作者：Mohamed A. Fakhfakh、Xavier Franck、Alian Fournet、Reynald Hocquemiller、Bruno Figadère

  DOI：10.1081/scc-120006472

  日期：2002.1

  ABSTRACT Quinolines substituted by a functionalized alkenyl or an alkynyl chain, either at the 2 or 3 position, were efficiently synthesized from 2-quinaldehyde and 3-bromoquinoline, respectively.

  摘要 由 2 位或 3 位官能化烯基或炔基链取代的喹啉分别由 2-喹醛和 3-溴喹啉有效合成。
• 헤테로고리 화합물 및 이를 이용한 유기 발광 소자
  申请人：LT Materials Co.,Ltd. 엘티소재주식회사(120060104982) Corp. No ▼ 110111-3251082BRN ▼104-81-94599

  公开号：KR20150132019A

  公开（公告）日：2015-11-25

  본 출원은 유기 발광 소자의 수명, 효율, 전기 화학적 안정성 및 열적 안정성을 크게 향상시킬 수 있는 헤테로고리 화합물, 및 상기 헤테로고리 화합물이 유기 화합물층에 함유되어 있는 유기 발광 소자를 제공한다.

  本申请提供了一种可以显著提高有机发光器件的寿命、效率、电化学稳定性和热稳定性的杂环化合物，以及包含该杂环化合物的有机发光器件。
• Regioselective allenylation and propargylation of various <i>para</i>-quinone methides using alkynyl azaarenes as pronucleophiles
  作者：Amritha Rayaroth、Afna Elikkottil、Chithra Mohan Jayakumari、Kalyanakrishnan Arayil Vennoli、Sivaranjana Reddy Vennapusa、Alagiri Kaliyamoorthy

  DOI：10.1039/d2cc03439e

  日期：——

  We have developed Brønsted base-mediated regioselective allenylation and propargylation of various para-quinone methides using unfunctionalized 2-alkynyl azaarenes as pronucleophiles.

  我们开发了Brønsted碱介导的选择性区域性联芳基化和丙炔基化方法，使用未功能化的2-炔基氮杂芳烃作为原核亲核试剂，对各种para-喹啉甲烷进行反应。
• Iron catalyzed hydrodebromination of 2-aryl-1,1-dibromo-1-alkenes
  作者：Mohamed Akram Fakhfakh、Xavier Franck、Reynald Hocquemiller、Bruno Figadère

  DOI：10.1016/s0022-328x(00)00934-7

  日期：2001.4

  2-Aryl- or 2-heteroaryl-1,1-dibromo-1-alkenes are reduced by Grignard reagents in a THF + NMP mixture in the presence of a catalytic amount of iron salts, to afford the corresponding E vinyl bromides. Further application to the one pot reduction-cross coupling reaction with Grignard reagents is highlighted. (C) 2001 Elsevier Science B.V. All rights reserved.