talaroconvolutin B

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: talaroconvolutin B
• 英文别名: 3-[(1R,2S,4aS,6S,8aR)-2-((E)-1,3-Dimethyl-pent-1-enyl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl]-5-hydroxy-5-(4-hydroxy-benzyl)-1,5-dihydro-pyrrol-2-one；ZG-1494alpha；3-[(1R,2S,4aS,6S,8aR)-3,4a,6-trimethyl-2-[(E)-4-methylhex-2-en-2-yl]-2,5,6,7,8,8a-hexahydro-1H-naphthalene-1-carbonyl]-5-hydroxy-5-[(4-hydroxyphenyl)methyl]-1H-pyrrol-2-one
• 化学式: C₃₂H₄₃NO₄
• 分子量: 505.698
• InChiKey: DZMMOKIPXHQOJN-KXVCVXEUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  乙醇 、 talaroconvolutin B 反应 40.0h， 以5 mg的产率得到3-[(1R,2S,4aS,6S,8aR)-2-((E)-1,3-Dimethyl-pent-1-enyl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl]-4-ethoxy-5-hydroxy-5-(4-hydroxy-benzyl)-pyrrolidin-2-one
  参考文献：
  名称：

  Antifungal Substances Against Pathogenic Fungi, Talaroconvolutins, from Talaromyces convolutus

  摘要：

  The dichloromethane extract of Talaromyces convolutus cultivated on barley exhibited antifungal activity against Candida albicans. In the course of a search for the active compounds, four new tetramic acid derivatives, talaroconvolutins A (1), B (2), C (3), and D (4), were isolated along with ZG-1494 alpha (5), and mitorubrin derivatives. The structures of talaroconvolutins A-D (1-4) were established on the basis of spectroscopic and chemical investigations and chemical correlations. The antifungal activity of the talaroconvolutins against the pathogenic fungi Aspergillus fumigates, Aspergillus niger, C. albicans, and Cryptococcus neoformans was determined.

  DOI：

  10.1021/np990371x
• 作为产物：
  描述：

  3-[(1R,2S,4aS,6S,8aR)-2-((E)-1,3-Dimethyl-pent-1-enyl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl]-4-ethoxy-5-hydroxy-5-(4-hydroxy-benzyl)-pyrrolidin-2-one 以 二甲基亚砜 为溶剂， 反应 24.0h， 生成 talaroconvolutin B
  参考文献：
  名称：

  Antifungal Substances Against Pathogenic Fungi, Talaroconvolutins, from Talaromyces convolutus

  摘要：

  The dichloromethane extract of Talaromyces convolutus cultivated on barley exhibited antifungal activity against Candida albicans. In the course of a search for the active compounds, four new tetramic acid derivatives, talaroconvolutins A (1), B (2), C (3), and D (4), were isolated along with ZG-1494 alpha (5), and mitorubrin derivatives. The structures of talaroconvolutins A-D (1-4) were established on the basis of spectroscopic and chemical investigations and chemical correlations. The antifungal activity of the talaroconvolutins against the pathogenic fungi Aspergillus fumigates, Aspergillus niger, C. albicans, and Cryptococcus neoformans was determined.

  DOI：

  10.1021/np990371x

文献信息

• Antifungal Substances Against Pathogenic Fungi, Talaroconvolutins, from <i>Talaromyces convolutus</i>
  作者：Shohei Suzuki、Tomoo Hosoe、Koohei Nozawa、Ken-ichi Kawai、Takashi Yaguchi、Shun-ichi Udagawa

  DOI：10.1021/np990371x

  日期：2000.6.1

  The dichloromethane extract of Talaromyces convolutus cultivated on barley exhibited antifungal activity against Candida albicans. In the course of a search for the active compounds, four new tetramic acid derivatives, talaroconvolutins A (1), B (2), C (3), and D (4), were isolated along with ZG-1494 alpha (5), and mitorubrin derivatives. The structures of talaroconvolutins A-D (1-4) were established on the basis of spectroscopic and chemical investigations and chemical correlations. The antifungal activity of the talaroconvolutins against the pathogenic fungi Aspergillus fumigates, Aspergillus niger, C. albicans, and Cryptococcus neoformans was determined.