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木犀草素-5-O-葡萄糖苷 | 20344-46-1

中文名称
木犀草素-5-O-葡萄糖苷
中文别名
藤黄菌素
英文名称
luteolin-5-O-β-D-glucopyranoside
英文别名
luteolin 5-O-β-D-glucopyranoside;luteolin-5-O-β-D-glucoside;luteolin 5-O-β-glucoside;luteolin 5-O-glucoside;luteolin-5-O-glucoside;luteolin 5-glucoside;2-(3,4-dihydroxyphenyl)-7-hydroxy-5-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
木犀草素-5-O-葡萄糖苷化学式
CAS
20344-46-1
化学式
C21H20O11
mdl
——
分子量
448.383
InChiKey
KBGKQZVCLWKUDQ-QNDFHXLGSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 熔点:
    260-263℃
  • 沸点:
    864.2±65.0 °C(Predicted)
  • 密度:
    1.713
  • 溶解度:
    溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。

计算性质

  • 辛醇/水分配系数(LogP):
    0
  • 重原子数:
    32
  • 可旋转键数:
    4
  • 环数:
    4.0
  • sp3杂化的碳原子比例:
    0.29
  • 拓扑面积:
    186
  • 氢给体数:
    7
  • 氢受体数:
    11

安全信息

  • 海关编码:
    2932999099

SDS

SDS:82f646a4fa9ecb718d79300eb55e6c63
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制备方法与用途

生物活性

Luteolin 5-O-葡萄糖苷来自刺苦菜,具有抗炎作用。它能够抑制由LPS诱导的NO生成和t-BHP诱导的ROS生成,并且在巨噬细胞中还能抑制iNOS和COX-2的表达。

体外研究

在RAW 264.7细胞中,非毒性浓度的Luteolin 5-O-葡萄糖苷以剂量依赖的方式抑制了由LPS诱导的NO生产以及由t-BHP诱导的ROS生成。此外,在脂多糖刺激的巨噬细胞中,它还抑制了iNOS和COX-2的表达。

上下游信息

  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量
    木犀草素 2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-on 491-70-3 C15H10O6 286.241

反应信息

  • 作为反应物:
    描述:
    参考文献:
    名称:
    Flavonoid 5-glucosides from Prunus cerasus bark and their characteristic weak glycosidic bonding
    摘要:
    Pinostrobin 5-glucoside, a novel flavanone glycoside, was isolated from the bark of Prunus cerasus. As it was not found in P. avium, the substance is useful to distinguish these two species. Apigenin 5-glucoside genkwanin 5-glucoside and neosakuranin were also isolated from the bark of P. cerasus. They occur in both species as minor components. These 5-glucosides together with genistein 5-glucoside, prunetin 5-glucoside, sakuranin, tectochrysin 5-glucoside and luteolin 5-glucoside were hydrolysed in malic acid. The isoflavone and flavone 5-glucosides were shown to be hydrolysed more rapidly than the flavanone 5-glucosides, whereas no hydrolysis was observed with the corresponding 7-glucosides under the same conditions. The chalcone 2'-glucoside neosakuranin was transformed at first to the corresponding flavanone 5-glucoside, which was hydrolysed thereafter.
    DOI:
    10.1016/0031-9422(91)84200-c
  • 作为产物:
    描述:
    (2S,3S,4S,5R,6R)-6-[[(2R,3R,4R,5R,6S)-6-[2-(3,4-dihydroxyphenyl)-7-hydroxy-4-oxochromen-5-yl]oxy-3,5-dihydroxy-4-[(2S,3R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid 生成 木犀草素-5-O-葡萄糖苷
    参考文献:
    名称:
    MEHROTRA, RAJ;AHMED, B.;VISHWAKARMA, R. A.;THAKUR, R. S., J. NATUR. PROD., 52,(1989) N, C. 640-643
    摘要:
    DOI:
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文献信息

  • Pharmaceutical composition containing substance inhibiting HSP47 production
    申请人:Kureha Chemical Industry Co., Ltd.
    公开号:EP0742012A2
    公开(公告)日:1996-11-13
    A pharmaceutical composition comprising a substance inhibiting HSP47 production, selected from the group consisting of a malt extract, a flavonoid compound, a protein-bound-polysaccharide obtained from a fungus belonging to Coriolus versicolor, a paeoniflorin derivative, a tocopherol derivative, and a ferulic acid derivative, and a pharmaceutically acceptable carrier is disclosed. The substance inhibiting HSP47 production can efficiently improve physiological conditions of a patient suffering from diseases exhibiting pathosis of overproduction of the extracellular matrix, and efficiently treat such diseases. Further, the substance is useful for preventing or treating various diseases accompanied with abnormal growth of the vascularization.
    本发明公开了一种药物组合物,该组合物包含一种抑制 HSP47 生成的物质,该物质选自麦芽提取物、黄酮类化合物、从属于 Coriolus versicolor 的真菌中获得的蛋白结合多糖、芍药苷衍生物、生育酚衍生物和阿魏酸衍生物组成的组,以及一种药学上可接受的载体。这种抑制 HSP47 生成的物质可以有效改善患有细胞外基质过度生成病症的患者的生理状况,并有效治疗此类疾病。此外,该物质还可用于预防或治疗伴有血管异常生长的各种疾病。
  • AQUEOUS SOLUTION COMPRISING AN INCLUSION COMPLEX, METHOD FOR OBTAINING SAME AND USE THEREOF FOR APPLICATION IN CROPS TO IMPROVE THEIR YIELD
    申请人:Universidad de Valladolid
    公开号:EP3987931A1
    公开(公告)日:2022-04-27
    The invention relates to an aqueous solution of an inclusion complex which comprises: a chitosan with a molecular weight comprised between 100,000 and 300,000 g/mol as a carrier agent and at least one biologically active compound applicable in agriculture selected from the group formed by: Equisetum arvense (Horsetail), Urtica spp (Nettle) extract, an amino acid, and any combination thereof. In addition, the invention relates to the method for obtaining the aqueous solution of the complex through the sonication of a gel previously obtained (also by sonication) from a chitosan gel with a carboxylic acid with the ABC. The invention further relates to the use of the aqueous solution to promote plant growth and to prevent pathogenic diseases in plants, uses which are significantly improved with respect to known compounds due to the synergistic effect found among their components.
    本发明涉及一种包含复合物的水溶液,该复合物包含:分子量在 100,000 至 300,000 g/mol 之间的壳聚糖作为载体,以及至少一种适用于农业的生物活性化合物,该化合物选自以下组成的组别:马尾草(马尾草)、荨麻提取物、氨基酸以及任何组合:马尾草(Equisetum arvense)、荨麻(Urtica spp)提取物、氨基酸及其任意组合。此外,本发明还涉及通过超声处理之前由壳聚糖凝胶与羧酸和 ABC(也通过超声处理)得到的凝胶来获得复合物水溶液的方法。本发明还涉及该水溶液在促进植物生长和预防植物病原性疾病方面的用途,与已知化合物相比,由于其成分之间的协同效应,该用途得到了显著改善。
  • Traditional Chinese medicine composition for treating psoriasis and method for preparing the same
    申请人:Beijing Zhendong Guangming Pharmaceutical Research Institute Co., LTD
    公开号:US10967030B2
    公开(公告)日:2021-04-06
    The invention relates to the field of traditional Chinese medicine, in particular to provides traditional Chinese medicine compositions for the treatment of psoriasis, their preparations and their preparation methods. The Chinese medicine compositions of the invention are consisted of 20-80 parts of Rumex madaio, 20-80 parts of Radix sophora flavescens, 10-50 parts of Herba Siphonostegiae, 10-40 parts of Chinese pulsatilla chinensis, and 5-30 parts of Acacia catechu, by weight. The invention also includes the preparation methods of the traditional Chinese medicine compositions and the preparations containing the traditional Chinese medicine compositions and method for preparing the same. The pharmacological experiments and clinical experiments proved that the traditional Chinese medicine compositions of the invention have remarkable curative effects on psoriasis vulgaris, high cure rate, no toxic and side effects of hormones, and is suitable for the characteristics of psoriasis having long-term use due to the long-course of the diseases.
    本发明涉及中药领域,尤其是提供治疗银屑病的中药组合物、其制剂及其制备方法。本发明的中药组合物由重量份数为20-80份的马钱子、20-80份的槐花、10-50份的四逆散、10-40份的黄连和5-30份的合欢花组成。本发明还包括中药组合物的制备方法和含有中药组合物的制剂及其制备方法。药理实验和临床实验证明,本发明的中药组合物对寻常型银屑病疗效显著,治愈率高,无激素毒副作用,适合银屑病病程长、长期服用的特点。
  • Herbal compositions for the prevention or treatment of urinary incontinence and overactive bladder
    申请人:Seipel Tracey Anne
    公开号:US11110141B2
    公开(公告)日:2021-09-07
    Provided in one embodiment is an herbal compositions for the prevention or treatment of urogenital system disorders including urinary incontinence, overactive bladder, enuresis, benign prostatic hyperplasia, nocturia, cystitis, urinary calculi, or a urinary tract infection. Specifically one embodiment provides compositions that contain Crateva nurvala, Equisetum arvense, and Lindera aggregata and methods of use thereof.
    在一个实施方案中,提供了一种草药组合物,用于预防或治疗泌尿生殖系统疾病,包括尿失禁、膀胱过度活动症、遗尿症、良性前列腺增生症、夜尿症、膀胱炎、尿路结石或尿路感染。具体来说,一个实施方案提供了含有Crateva nurvala、Equisetum arvense和Lindera aggregata的组合物及其使用方法。
  • [DE] NEUE VERWENDUNGEN VON EQUISETUM<br/>[EN] NEW USE OF EQUISETUM<br/>[FR] NOUVELLE UTILISATION DE L'EQUISETUM
    申请人:KÖNIGER, Helmut
    公开号:WO1994025041A1
    公开(公告)日:1994-11-10
    (DE) Die Erfindung betrifft die Verwendung von Bestandteilen von Pflanzen der Gattung Equisetum (Schachtelhalm), insbesondere der Art Equisetum arvense, zur topischen Bekämpfung von Psoriasis, von unreiner Haut, Pickeln, Akne, Brandwunden, Sonnenallergien, allergischen Kontakt-Hauterkrankungen, Kopfschuppen, von Muskel- Sehnen-, Bänder-, Gelenk- und neuralgischen Schmerzen einschließlich Gichtschmerzen sowie von Nagelpilz bzw. ein entsprechendes Behandlungsverfahren. Weiter betrifft die Erfindung eine pharmazeutische Zusammensetzung von Saft oder Extrakt von Pflanzen der Gattung Equisetum, in dem diese Bestandteile in einer Konzentration von 5-45 Volumenprozent vorliegen.(EN) The invention pertains to the use of constituents of plants of the genus $i(Equisetum) (horstail), in particular the species $i(Equisetum) arvense, for topical treatment of psoriasis, dirty skin, pimples, acne, burns, sun allergies, allergic contact skin diseases and dandruff; of muscle, tendon, ligament, joint and neuralgic pains including gouty pains, and of nail fungus, or to a corresponding method of treatment. Further, the invention pertains to a pharmaceutical composition of juice or extract of plants of the genus $i(Equisetum) in which these constituents are present in a concentration of 5-45 % by volume.(FR) L'invention concerne l'utilisation de constituants de plantes de l'espèce Equisetum (prêle), notamment du genre Equisetum arvense, pour lutter de manière topique contre le psoriasis, les impuretés de la peau, les petits boutons, l'acné, les brûlures, les allergies solaires, les maladies cutanées allergiques par contact, les pellicules du cuir chevelu, les douleurs musculaires, les ténalgies, les douleurs ligamentaires, articulaires et névralgiques, y compris les douleurs dues à la goutte, ainsi que les mycoses des ongles. L'invention concerne également une méthode de traitement appropriée, ainsi qu'une composition pharmaceutique de jus ou d'extrait de plantes du genre Equisetum dans laquelle ces constituants se trouvent en une concentration comprise entre 5 et 45 % en volume.
    该发明涉及对_close2_植物 genus(防thagata)植物(尤其是 Close2_物种)的成分在 topical治疗湿疹、清洁皮肤、粉刺、}`, 瘦皮症、烧伤、紫外线过敏、过敏性皮肤疾病、头皮屑、肌肉痛、腱鞘痛、关节痛和神经痛(包括痛)以及甲 nails真菌或其他相应处理方法。此外,该发明还涉及一种把 genus (防thagata) 植物的果汁或提取物制成的制药复合物,其中这些成分以 5~45%的体积分数存在。
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