1-(4-Beta-羟基乙基磺酰基苯基-)-3-甲基-5-吡唑酮 | 21951-34-8

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 1-(4-Beta-羟基乙基磺酰基苯基-)-3-甲基-5-吡唑酮
• 中文别名: 2,4-二氢-2-[4-[(2-羟基乙基)磺酰基]苯基]-5-甲基-3H-吡唑-3-酮
• 英文名称: 3H-Pyrazol-3-one, 2,4-dihydro-2-[4-[(2-hydroxyethyl)sulfonyl]phenyl]-5-methyl-
• 英文别名: 2-[4-(2-hydroxyethylsulfonyl)phenyl]-5-methyl-4H-pyrazol-3-one
• CAS: 21951-34-8
• 化学式: C₁₂H₁₄N₂O₄S
• 分子量: 282.32
• InChiKey: HYQYPARBQHUKAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  95.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• INHALANT FORMULATIONS COMPRISING A BISPHOSPHONATE AND A PYRAZOLONE DERIVATIVE AND METHODS FOR USING THE SAME
  申请人：Hibi Toru

  公开号：US20100034752A1

  公开（公告）日：2010-02-11

  The present invention provides for methods of administering by a pulmonary route a bisphosphonate active agent in combination with a pyrazolone derivative to a subject. Also provided are pharmaceutical compositions for use in practicing methods according to embodiments of the invention. The methods and compositions according to embodiments of the invention find use in a variety of different applications, including but not limited to, the treatment of bone absorption disease conditions.
• [EN] INHALANT FORMULATIONS COMPRISING A BISPHOSPHONATE AND A PYRAZOLONE DERIVATIVE AND METHODS FOR USING THE SAME<br/>[FR] FORMULATIONS POUR INHALATION COMPRENANT UN BISPHOSPHONATE ET UN DÉRIVÉ DE PYRAZOLONE ET LEURS MÉTHODES D'UTILISATION
  申请人：TEIKOKU PHARMA USA INC

  公开号：WO2010068358A1

  公开（公告）日：2010-06-17

  The present invention provides for methods of administering by a pulmonary route a bisphosphonate active agent in combination with a pyrazolone derivative to a subject. Also provided are pharmaceutical compositions for use in practicing methods according to embodiments of the invention. The methods and compositions according to embodiments of the invention find use in a variety of different applications, including but not limited to, the treatment of bone absorption disease conditions.