正丁基氯化汞 | 543-63-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 金属烷基卤化物
• 中文名称: 正丁基氯化汞
• 英文名称: n-butylmercuric chloride
• 英文别名: n-Butylquecksilberchlorid；Butylquecksilberchlorid
• CAS: 543-63-5
• 化学式: C₄H₉ClHg
• 分子量: 293.158
• InChiKey: OKPMTXZRMGMMOO-UHFFFAOYSA-M

物化性质

• 熔点：
  130°

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  6
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2931900090
• 储存条件：
  库房应保持通风、低温和干燥，并与食品原料分开存放。

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : BUTYLMERCURIC CHLORIDE
CAS-No. : 543-63-5
Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute toxicity, Inhalation (Category 2)
Acute toxicity, Dermal (Category 1)
Acute toxicity, Oral (Category 2)
Specific target organ toxicity - repeated exposure (Category 2)
Acute aquatic toxicity (Category 1)
Chronic aquatic toxicity (Category 1)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Very toxic by inhalation, in contact with skin and if swallowed. Danger of cumulative effects. Very toxic to
aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Danger
Hazard statement(s)
H300 Fatal if swallowed.
H310 Fatal in contact with skin.
H330 Fatal if inhaled.
H373 May cause damage to organs through prolonged or repeated exposure.
H410 Very toxic to aquatic life with long lasting effects.
Precautionary statement(s)
P260 Do not breathe dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash hands thoroughly after handling.
P273 Avoid release to the environment.
P280 Wear protective gloves/ protective clothing.
P284 Wear respiratory protection.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/
physician.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed.
R33 Danger of cumulative effects.
R50/53 Very toxic to aquatic organisms, may cause long-term adverse effects in
the aquatic environment.
S-phrase(s)
S45 In case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : C4H9ClHg
Molecular Weight : 293,16 g/mol
Component Concentration
BUTYLMERCURIC CHLORIDE
CAS-No. 543-63-5 -
Index-No. 080-004-00-7

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Hydrogen chloride gas, Mercury/mercury oxides.
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate
personnel to safe areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the
environment must be avoided.
Methods and materials for containment and cleaning up
Soak up with inert absorbent material and dispose of as hazardous waste. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapour or mist.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face respirator
with multi-purpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup
to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air
respirator. Use respirators and components tested and approved under appropriate government
standards such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: liquid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Inhalation: no data available
Dermal: no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
Causes damage to organs through prolonged or repeated exposure.
Aspiration hazard
no data available
Potential health effects
Inhalation May be fatal if inhaled. May cause respiratory tract irritation.
Ingestion May be fatal if swallowed.
Skin May be fatal if absorbed through skin. May cause skin irritation.
Eyes May cause eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: OV7700000

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
Very toxic to aquatic life.
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: 2810 IMDG: 2810 IATA: 2810
UN proper shipping name
ADR/RID: TOXIC LIQUID, ORGANIC, N.O.S. (BUTYLMERCURIC CHLORIDE)
IMDG: TOXIC LIQUID, ORGANIC, N.O.S. (BUTYLMERCURIC CHLORIDE)
IATA: Toxic liquid, organic, n.o.s. (BUTYLMERCURIC CHLORIDE)
Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
Packaging group
ADR/RID: II IMDG: II IATA: II
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available

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Section 16. OTHER INFORMATION
Further information
Copyright 2012 Co. LLC. License granted to make unlimited paper copies for internal use
only.
The above information is believed to be correct but does not purport to be all inclusive and shall be
used only as a guide. The information in this document is based on the present state of our knowledge
and is applicable to the product with regard to appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Corporation and its Affiliates shall not be held
liable for any damage resulting from handling or from contact with the above product. See
and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.

制备方法与用途

类别：有毒物质
毒性分级：高毒
急性毒性（皮下-大鼠）：LDL0 73毫克/公斤

可燃性危险特性：热分解时排出有毒氯化物和含汞化合物烟雾

储运特性：库房应通风、低温干燥，并与食品原料分开存放

灭火剂：水、干粉、二氧化碳、泡沫

职业标准：时间加权平均容许浓度（TWA）0.01毫克/立方米；短时间接触容许浓度（STEL）0.03毫克/立方米

反应信息

• 作为反应物：
  描述：

  正丁基氯化汞 在 乙醇 、 一水合肼 作用下， 生成 二丁基汞
  参考文献：
  名称：

  Gilman; Barnett, Recueil des Travaux Chimiques des Pays-Bas, 1936, vol. 55, p. 563,565

  摘要：

  DOI：
• 作为产物：
  描述：

  二丁基汞 在 盐酸 、 乙醇 作用下， 生成 正丁基氯化汞
  参考文献：
  名称：

  Marvel; Gould, Journal of the American Chemical Society, 1922, vol. 44, p. 154

  摘要：

  DOI：
• 作为试剂：
  描述：

  2-氯-1-苯基-2-丙烯-1-酮 在 正丁基氯化汞 、 sodium thiosulfate 、 三苯基硅烷 作用下， 生成 2-氯苯丙酮 、 2-氯-1-苯基庚烷-1-酮
  参考文献：
  名称：

  Russell, Glen A.; Shi, Bing Zhi; Jiang, Wan, Journal of the American Chemical Society, 1995, vol. 117, # 14, p. 3952 - 3962

  摘要：

  DOI：

文献信息

• Substitution at saturated carbon. Part XIII. Steric effects in the substitution of tetra-alkyltin compounds by mercury(II) chloride in t-butyl alcohol and in acetonitrile
  作者：M. H. Abraham、F. Behbahany、M. J. Hogarth

  DOI：10.1039/j19710002566

  日期：——

  previously for the substitution of tetra-alkyltins by mercury(II) chloride in methanol and methanol–water mixtures. It is concluded that the above substitutions in solvents t-butyl alcohol and acetonitrile proceed by essentially the same mechanism as do the corresponding substitutions in solvents methanol and methanol–water, that is by the SE2(open) mechanism of substitution at saturated carbon.

  已确定了在溶剂叔丁醇和乙腈中用氯化汞（II）取代四甲基，四乙基，四正丙基，四异丙基，四正丁基和四异丁基锡的速率常数。。对于这两种溶剂，速率常数沿R 4 Sn = Me 4 Sn Et 4 Sn> Pr n 4 Sn Bu n 4 Sn> Bu i 4 Sn Pr i 4 Sn序列显着降低，因此产生相同的空间顺序以前发现的被汞取代四烷基锡的反应性（II）在甲醇和甲醇-水混合物中的氯化物。结论是，上述在叔丁醇和乙腈溶剂中的取代基本上是通过与在溶剂甲醇和甲醇-水中的相应取代相同的机理进行的，即通过在饱和碳原子上的S E 2（open）取代机理进行的。 。
• Substitution at saturated carbon. Part V. The bimolecular electrophilic substitution of several tetra-alkyltins by mercuric chloride in methanol–water mixtures. Kinetics, mechanism, and activation parameters
  作者：M. H. Abraham、G. F. Johnston

  DOI：10.1039/j19700000193

  日期：——

  coefficients and activation parameters are reported for the substitution of tetramethyl-, tetra-n-propyl-, tetra-n-butyl-, and tetraisobutyl-tin by mercuric chloride in methanol–water mixtures of mole fraction methanol 1, 0·91, and 0·72. In addition, an upper limit can be set for the rate coefficient for substitution of tetraisopropyltin by mercuric chloride. The rate coefficients decrease in value markedly

  据报道，在摩尔分数为1，0的甲醇-甲醇混合物中，氯化汞可以用氯化汞取代四甲基，四正丙基，四正丁基和四异丁基锡的二阶速率系数和活化参数。 ·91和0·72。另外，可以设定氯化汞取代四异丙基锡的速率系数的上限。速率系数的值沿序列R 4 Sn = Me 4 Sn Et 4 Sn> Pr n 4 Sn Bu n 4 Sn> Bu i 4 Sn Pr i 4显着减小用锡替代三种使用的溶剂混合物。尽管随着溶剂中水含量的增加，任何给定的四烷基锡的取代率系数都显着增加，但是与取代四甲基锡的比率相比，相对速率系数几乎不受溶剂组成变化的影响。结论是，在所使用的三种溶剂混合物中，氯化汞对四烷基锡的取代是通过饱和碳上亲电取代的S E 2（open）机理，通过已经发生大量电荷分离的过渡态进行的。
• Substitution at saturated carbon. Part II. Kinetics and mechanism of the electrophilic substitution of several tetra-alkyltins by mercuric iodide in solvent 96% methanol–4% water
  作者：M. H. Abraham、T. R. Spalding

  DOI：10.1039/j19690000399

  日期：——

  The substitution of tetra-alkyltins by mercuric iodide in solvent 96% methanol–4% water proceeds by the rate-determining bimolecular reaction R4Sn + Hgl2→ RHgl + R3Snl, followed by the rapid reversible reaction R3Snl + Hgl2⇌ R3Sn++ Hgl3–. Second-order rate coefficients, at 25 and at 40°, of reaction (1) have been obtained for the substitution of tetramethyl-, tetra-n-propyl-, tetra-n-butyl-, tetraisobutyl-

  通过确定反应速率的双分子反应R 4 Sn + HGl 2 → RHGl + R 3 Snl，然后进行快速可逆反应R 3 Snl + HGl，在96％甲醇–4％水中的碘化汞取代四烷基锡。2 ⇌ - [R 3的Sn + + HGL 3 -。已获得反应（1）在25°和40°的二阶速率系数，用于取代四甲基，四正丙基，四正丁基，四异丁基和甲基三正丁基。丁基锡，并确定各种活化参数。还获得了在40°下的二阶速率系数，用于替代四异丙基锡。
• Vibrational and nuclear magnetic resonance studies of the formation of alkylmercury(II) halide complex anions
  作者：Peter L. Goggin、Robin J. Goodfellow、Nicholas W. Hurst

  DOI：10.1039/dt9780000561

  日期：——

  EtCl, PrnCl, BunCl, EtBr, PrnBr, BunBr, or Etl). The effects of the addition of halide ions on δ(199Hg), measured by 1H-199Hg} INDOR, and 2J(HgH) have been investigated and compared with the effects of solvents on these parameters. It is suggested that the complexes have an essentially linear RHgX group with the second halide much more weakly attached in the equatorial plane.

  振动光谱测量表明，[HGMeCl 2 ] –由[HGMe（Cl）]和[NBu n 4 ] Cl在苯，氯仿，二氯甲烷，四氢呋喃和乙腈中形成，但在甲醇或水中则没有。络合阴离子的类似形成发生为[HGMe（X）（X = Br的，I，或SCN）和[HGR（X）]（RX = ETCL，镨Ñ氯，卜Ñ氯，溴化乙锭，镨Ñ BR，卜ñ Br或ETL）。通过1 H- 199 HG} INDOR和2 J测量的添加卤离子对δ（199 HG）的影响（HGH）已被研究，并与溶剂对这些参数的影响进行了比较。建议该络合物具有基本线性的RHGX基团，第二个卤化物在赤道平面上的连接弱得多。
• Studies on a new class of organobimetallic compounds
  作者：P.P. Singh、M.P. Reddy、Subir Kumar

  DOI：10.1016/0022-2860(82)80041-0

  日期：1982.7

  Abstract Organometallic compounds of general formula (SCN) 2 Ni(NCSHgR) 2 (R = CH 3 , C 2 H 5 , n-C 4 H 9 and iso-C 4 H 9 ) have been synthesized. These organometallic compounds behave as Lewis acids and form complexes with pyridine, nicotinamide and 2,2'-bipyridyl. The Lewis acids and the complexes are characterized by elemental analysis, molecular weight determination, molar conductance, IR spectral

  摘要 已合成通式 (SCN) 2 Ni(NCSHgR) 2 (R = CH 3 、C 2 H 5 、nC 4 H 9 和异-C 4 H 9 ) 的有机金属化合物。这些有机金属化合物表现为路易斯酸，并与吡啶、烟酰胺和 2,2'-联吡啶形成络合物。路易斯酸和配合物的特征在于元素分析、分子量测定、摩尔电导、红外光谱（4000-50 cm -1 ）、电子光谱和磁化率测量。这些研究表明路易斯酸本质上是单体，在Ni 2+ 和Hg 2+ 之间桥接硫氰酸盐。镍通过轴向桥接获得八面体构型，而汞保持其线性。吡啶和烟酰胺在路易斯酸的镍处连接并形成式L 2 (SCN) 2 Ni(NCSHgR) 2 的加合物。联吡啶使硫氰酸酯桥断裂并形成阳离子-阴离子复合物 [Ni(bipy) 3 ] [(NCS) 2 HgR] 2 。软度值也以一种新颖的方式用于提出复合物的结构和建议路易斯酸的相对行为。