1-苄基-4-甲基-1,2-二氢喹啉 | 402822-97-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 1-苄基-4-甲基-1,2-二氢喹啉
• 英文名称: 1-benzyl-4-methyl-2H-quinoline
• CAS: 402822-97-3
• 化学式: C₁₇H₁₇N
• 分子量: 235.329
• InChiKey: UHCFQVYRKTZCNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-苄基-4-甲基-1,2-二氢喹啉 在 氢气 、 air 作用下， 生成 4-甲基喹啉
  参考文献：
  名称：

  Synthesis of substituted 1,2-dihydroquinolines and quinolines using ene–ene metathesis and ene–enol ether metathesis

  摘要：

  We describe a novel and convenient method for quinoline synthesis using ring-closing olefin metathesis (RCM), ene-ene metathesis, and ene-enol ether metathesis. We also report the first example of enol silyl ether-ene metathesis to produce cyclic enol silyl ether. Using this method, versatile substituted quinoline derivatives were readily prepared in excellent yield from anthranilic acid derivatives. C 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01714-2
• 作为产物：
  描述：

  N-benzyl-2-isopropenylaniline 在 Grubbs catalyst first generation 、 sodium hydride 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 1-苄基-4-甲基-1,2-二氢喹啉
  参考文献：
  名称：

  A novel synthesis of substituted quinolines using ring-closing metathesis (RCM): its application to the synthesis of key intermediates for anti-malarial agents

  摘要：

  A method for synthesizing substituted quinolines using ruthenium-catalyzed ring-closing metathesis as a key step has been developed. Substituted 1,2-dihydroquinolines, 4-silyloxy-1,2-dihydroquinoline and 4-methoxy-1,2-dihydroquinoline, were successfully synthesized in excellent yields via ene-ene metathesis and silyl or alkyl enol ether-ene metathesis, respectively. The synthetic intermediates of the antimalarial agents quinine, chloroquine, and PPMP-quinine hybrid were efficiently synthesized by this methodology. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.01.084

文献信息

• WHITE BLOOD CELL DIFFERENTIATION REAGENT AND METHOD OF USE THEREOF
  申请人：Xu Bing

  公开号：US20090023129A1

  公开（公告）日：2009-01-22

  The present disclosure provides a white blood cell differentiation reagent comprising a fluorescent dye compound of Formula I, wherein R 1 , R 2 , R 3 , R 4 , Y − and n are as defined in the specification. The present disclosure also provides a white blood cell detection kit comprising the white blood cell differentiation reagent, and a method of differentiating white blood cells using the white blood cell differentiation reagent.

  本公开提供了一种白细胞分化试剂，包括化学式I的荧光染料化合物，其中R1、R2、R3、R4、Y-和n如规范中所定义。本公开还提供了一种白细胞检测试剂盒，包括白细胞分化试剂，以及使用该白细胞分化试剂区分白细胞的方法。
• One-Pot Ring-Closing Metathesis/1,3-Dipolar Cycloaddition through Assisted Tandem Ruthenium Catalysis: Synthesis of a Dye with Isoindolo[2,1-<i>a</i>]quinoline Structure
  作者：Mitsuhiro Arisawa、Yuki Fujii、Hiroshige Kato、Hayato Fukuda、Takashi Matsumoto、Mika Ito、Hiroshi Abe、Yoshihiro Ito、Satoshi Shuto

  DOI：10.1002/anie.201206765

  日期：2013.1.14

  The one‐pot tandem reaction of N‐alkyl‐N‐allyl‐2‐vinylaniline derivatives with benzo‐ or naphthoquinones and a ruthenium–alkylidene catalyst leads to isoindolo[2,1‐a]quinolines in a variety of colors, which can be altered by exchanging the substituent on the core heterocycle (see scheme). This reaction offers a new synthetic method for π‐conjugated small molecules from simple aniline derivatives.

  一锅串联反应的ñ -烷基- ñ与苯并或萘醌-烯丙基-2-乙烯基苯胺衍生物和钌-亚烷基催化剂导致异吲哚基[2,1-一个〕喹啉在有多种颜色，其可以是通过交换核心杂环上的取代基进行更改（请参见方案）。该反应为由简单的苯胺衍生物衍生的π共轭小分子提供了一种新的合成方法。
• FLUORESCENT DYES,METHODS OF SYNTHESIS AND APPLICATIONS THEREOF
  申请人：Peng Xiaojun

  公开号：US20110262904A1

  公开（公告）日：2011-10-27

  The present invention provides a category of cyanine dyes having the following general structural Formula I, wherein X is defined as C(CH 3 ) 2 , O, S or Se; m is an integer from 1 to 18, R 1 and R 2 are each independently chosen from H, C 1-18 alkyl, OR 7 , C 1-6 alkyl-OR 7 or halogen; R 3 is pyrrolyl, imidazolyl, piperidinyl, piperazinyl, morpholinyl, guanidino, NHR 5 or N(R 6 ) 2 ; R 4 is C 1-18 alkyl, benzyl or (CH 2 ) m R 3 ; R 5 is saturated and/or unsaturated, straight-chained and/or branched-chained C 1-18 alkyl, hydroxy alkyl, mercapto-alkyl, amino alkyl, acyl, phenyl, naphthyl or benzyl; R 6 is a C 2-18 alkyl; R 7 is H or a C 1-18 alkyl; Y − is an anion. The mentioned compounds can be applied to staining biological samples, to the fields of nucleic acids labeling, blood cell analysis, clinical diagnosis, immunological assays and etc.
• US7960099B2
  申请人：——

  公开号：US7960099B2

  公开（公告）日：2011-06-14
• US8298766B2
  申请人：——

  公开号：US8298766B2

  公开（公告）日：2012-10-30